POLR3F - RNA polymerase III subunit F Gene

Homo sapiens

Also known as C34; RPC6; RPC39; IMD101

Gene ID: 10621 | Gene type: protein coding

About POLR3F

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:18,467,390-18,484,646 (from NCBI)

This gene has 22 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in brain (RPKM 6.9), thyroid (RPKM 6.8) and 25 other tissues.

Summary

The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the Other RNA Pol III subunits, the encoded protein is unique to this polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

POLR3F Products(3)

mRNA	Protein	Name
NM_001282526.2	NP_001269455.1	DNA-directed RNA polymerase III subunit RPC6 isoform 2
NM_001410821.1	NP_001397750.1	DNA-directed RNA polymerase III subunit RPC6 isoform 3
NM_006466.4	NP_006457.2	DNA-directed RNA polymerase III subunit RPC6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 4 iron, 4 sulfur cluster binding	IDA IDA: Inferred from direct assay	34675218	GOA
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	21358628	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11416169	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	19631370	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	19631370	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase III complex	IDA IDA: Inferred from direct assay	24107381	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR3F Protein Structure

RNA_pol_Rpc34

0
100
200
316 a.a.

Protein Preferred Names

Protein Names

DNA-directed RNA polymerase III subunit RPC6

RNA polymerase III C39 subunit

POLR3F Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	POLR3F	Q9H1D9	EIF2S3	Homo sapiens	P41091	Y2H Array	32814053
Intra	POLR3F	Q9H1D9	EIF2S3	Homo sapiens	P41091	Y2H Pooling	32814053
Intra	POLR3F	Q9H1D9	EIF2S3	Homo sapiens	P41091	Validated Y2H	32814053
Intra	POLR3F	Q9H1D9	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	POLR3F	Q9H1D9	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	POLR3F	Q9H1D9	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	POLR3F	Q9H1D9	POLR3G	Homo sapiens	O15318	Anti Tag CoIP	35271311
Intra	POLR3F	Q9H1D9	POLR3G	Homo sapiens	O15318	Anti Bait CoIP	20154270
Intra	POLR3F	Q9H1D9	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	POLR3F	Q9H1D9	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	POLR3F	Q9H1D9	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	POLR3F	Q9H1D9	PNRC1	Homo sapiens	Q12796	Y2H	17612402
Intra	POLR3F	Q9H1D9	POLR3GL	Homo sapiens	Q9BT43	Anti Tag CoIP	35271311
Intra	POLR3F	Q9H1D9	POLR3GL	Homo sapiens	Q9BT43	Anti Bait CoIP	20154270
Intra	POLR3F	Q9H1D9	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	POLR3F	Q9H1D9	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	POLR3F	Q9H1D9	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	POLR3F	Q9H1D9	PRP4K	Homo sapiens	Q13523	Y2H Pooling	16169070
Intra	POLR3F	Q9H1D9	PRP4K	Homo sapiens	Q13523	Anti Tag CoIP	16169070
Intra	POLR3F	Q9H1D9	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	POLR3F	Q9H1D9	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	POLR3F	Q9H1D9	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	POLR3F	Q9H1D9	POLR3C	Homo sapiens	Q9BUI4	Anti Tag CoIP	35271311
Intra	POLR3F	Q9H1D9	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	POLR3F	Q9H1D9	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	POLR3F	Q9H1D9	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	POLR3F	Q9H1D9	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	POLR3F	Q9H1D9	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	POLR3F	Q9H1D9	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immunodeficiency 101

IMD101

Corneal Dystrophy, Posterior Polymorphous, 1

Posterior Polymorphous Corneal Dystrophy	Ppcd
Maumenee Corneal Dystrophy	Posterior Polymorphous Corneal Dystrophy 1
PPCD1	Corneal Dystrophy, Hereditary Polymorphous Posterior
Corneal Endothelial Dystrophy 1, Autosomal Dominant	Schlichting Dystrophy
Ched1	Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly
Ched1, Formerly	Hereditary Polymorphus Posterior Corneal Dystrophy
Posterior Polymorphous Dystrophy	Hereditary Polymorphous Posterior Corneal Dystrophy
Dystrophy, Corneal, Posterior Polymorphous	Dystrophy, Corneal, Posterior Polymorphous, Type 1
Polymorphous Corneal Dystrophy	Corneal Endothelial Dystrophy 2

Hypomyelinating Leukoencephalopathy

Anauxetic Dysplasia 1

Anauxetic Dysplasia	Spondylometaepiphyseal Dysplasia, Menger Type
Spondylometaepiphyseal Dysplasia, Anauxetic Type	Spondyloepimetaphyseal Dysplasia, Anauxetic Type
ANXD1	Anxd
Spondylometaepiphyseal Dysplasia Anauxetic Type	Spondylometaepiphyseal Dysplasia Menger Type
Ad	Spondyloepimetaphyseal Dysplasia, Menger Type
Dysplasia, Anauxetic, Type 1

Hypomyelinating Leukodystrophy

Hld	Leukodystrophy, Hypomyelinating

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10859	POLR3F Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	POLR3F	VGNC	VGNC:64294
Macaca mulatta	POLR3F	VGNC	VGNC:76032
Bos taurus	POLR3F	VGNC	VGNC:33150
Canis familiaris	POLR3F	VGNC	VGNC:44804
Rattus norvegicus	POLR3F	RGD	RGD:1306428
Mus musculus	POLR3F	MGD	MGI:1924086

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