2. Gene
  3. IGF2BP1 - insulin like growth factor 2 mRNA binding protein 1 Gene

IGF2BP1 - insulin like growth factor 2 mRNA binding protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IMP1; ZBP1; CRDBP; IMP-1; CRD-BP; VICKZ1

Gene ID: 10642 | Gene type: protein coding

About IGF2BP1

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,996,558-49,056,145 (from NCBI)

This gene has 6 transcripts (splice variants), 146 orthologues and 12 paralogues. Biased expression in testis (RPKM 3.6), placenta (RPKM 2.9) and 1 other tissue.

Summary

This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

IGF2BP1 Products(2)

mRNA Protein Name
NM_001160423.2 NP_001153895.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform 2
NM_006546.4 NP_006537.3 insulin-like growth factor 2 mRNA-binding protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables N6-methyladenosine-containing RNA reader activity IDA
IDA: Inferred from direct assay
29476152 GOA
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
20080952 GOA
enables mRNA 5'-UTR binding IDA
IDA: Inferred from direct assay
9891060 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
17101699 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17289661 GOA
enables translation regulator activity IDA
IDA: Inferred from direct assay
9891060 GOA
Biological Process GO Annotation Evidence Reference Source
involved in CRD-mediated mRNA stabilization IDA
IDA: Inferred from direct assay
19029303 GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
IDA: Inferred from direct assay
19029303 GOA
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
9891060 GOA
involved in positive regulation of cytoplasmic translation IDA
IDA: Inferred from direct assay
19029303 GOA
involved in regulation of mRNA stability involved in response to stress IMP
IMP: Inferred from mutant phenotype
17101699 GOA
Cellular Component GO Annotation Evidence Reference Source
part of CRD-mediated mRNA stability complex IDA
IDA: Inferred from direct assay
19029303 GOA
part of CRD-mediated mRNA stability complex IPI
IPI: Inferred from physical interaction
19029303 GOA
located in P-body IDA
IDA: Inferred from direct assay
29476152 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
9891060 GOA
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
17101699 GOA
located in cytosol IDA
IDA: Inferred from direct assay
19029303 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
17289661 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGF2BP1 Protein Structure

(4 - 69)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (85 - 150)

KH_1

KH_1: KH domain (198 - 260)

KH_1

KH_1: KH domain (280 - 343)

KH_1

KH_1: KH domain (409 - 469)

KH_1

KH_1: KH domain (490 - 553)

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  • 577 a.a.
Protein Preferred Names Protein Names

insulin-like growth factor 2 mRNA-binding protein 1

IGF-II mRNA-binding protein 1

IGF2BP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
IGF2BP1 Q9NZI8 DYRK1A Homo sapiens Q13627
Anti Bait CoIP
36950384
Intra
IGF2BP1 Q9NZI8 MOV10 Homo sapiens Q9HCE1
Anti Tag CoIP
35271311
Intra
IGF2BP1 Q9NZI8 STAU1 Homo sapiens O95793
Anti Tag CoIP
19029303
Intra
IGF2BP1 Q9NZI8 STAU1 Homo sapiens O95793
Anti Tag CoIP
35271311
Intra
IGF2BP1 Q9NZI8 STAU1 Homo sapiens O95793
Confocal
19029303
Cross: Cross-species interaction Intra: Intraspecies interaction

IGF2BP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83326 IGF2BP1 Antibody (YA3071) WB, IHC-P, IP Human, Mouse

Related Diseases

Diseases Alias
Thyroid Sarcoma

Sarcoma Of The Thyroid Gland

Thyroid Gland Sarcoma
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Microphthalmia

Microphthalmos

Isolated Anophthalmia-Microphthalmia Syndrome

Isolated Microphthalmia-Anophthalmia-Coloboma

Simple Microphthalmos

Clinical Anophthalmia

Isolated Anophthalmia - Microphthalmia

Isolated Pure Microphthalmia

Mac Spectrum

Microphthalmia-Anophthalmia-Coloboma Spectrum

Primitive Anophthalmia

Globe Of Eye Small

Small Eyeball

Hypoplasia Of Eye

Isolated Nanophthalmos

Rudimentary Eye

Dysplasia Of Eye
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-144873 AVJ16 99.60% Unkown
HY-156110 IGF2BP1-IN-1 Inhibitor 99.94% Unkown
HY-RS06619 IGF2BP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris IGF2BP1 VGNC VGNC:41898
Macaca mulatta IGF2BP1 VGNC VGNC:73452
Felis catus IGF2BP1 VGNC VGNC:62888
Rattus norvegicus IGF2BP1 RGD RGD:708580
Bos taurus IGF2BP1 VGNC VGNC:30079
Mus musculus IGF2BP1 MGD MGI:1890357