DYRK1A - dual specificity tyrosine phosphorylation regulated kinase 1A Gene

Homo sapiens

Also known as MNB; DYRK; HP86; MNBH; MRD7; DYRK1

Gene ID: 1859 | Gene type: protein coding

About DYRK1A

Cytogenetic location: 21q22.13 Genomic coordinates (GRCh38): 21:37,365,573-37,526,358 (from NCBI)

This gene has 23 transcripts (splice variants), 236 orthologues, 12 paralogues and is associated with 4 phenotypes. Ubiquitous expression in bone marrow (RPKM 11.6), testis (RPKM 9.5) and 25 other tissues.

Summary

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat DYRK gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each Other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]

DYRK1A Products(18)

mRNA	Protein	Name
XM_005260933.6	XP_005260990.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X5
XM_006723977.4	XP_006724040.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2
NM_001396.5	NP_001387.2	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1
XM_024452057.2	XP_024307825.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X4
XM_047440704.1	XP_047296660.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1
NM_130436.2	NP_569120.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 2
XM_047440701.1	XP_047296657.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1
NM_101395.2	NP_567824.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 3
XM_047440702.1	XP_047296658.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1
XM_047440706.1	XP_047296662.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X3
XM_047440703.1	XP_047296659.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1
NM_001347723.2	NP_001334652.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 6
NM_130437.2
NM_001347721.2	NP_001334650.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 2
XM_047440705.1	XP_047296661.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1
NM_001347722.2	NP_001334651.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 2
NM_130438.2	NP_569122.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 5
XM_047440700.1	XP_047296656.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA IDA: Inferred from direct assay	25620562	GOA
enables actin binding	IPI IPI: Inferred from physical interaction	24327345	GOA
enables cytoskeletal protein binding	IPI IPI: Inferred from physical interaction	24327345	GOA
enables histone H3T45 kinase activity	IDA IDA: Inferred from direct assay	24820035	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	23665168	GOA
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	9748265	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14500717	GOA
enables protein serine kinase activity	IDA IDA: Inferred from direct assay	30773093	GOA
enables protein serine/threonine kinase activity	IGI IGI: Inferred from genetic interaction	17906291	GOA
enables tubulin binding	IPI IPI: Inferred from physical interaction	24327345	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in amyloid-beta formation	IMP IMP: Inferred from mutant phenotype	25556849	GOA
involved in negative regulation of DNA methylation-dependent heterochromatin formation	IDA IDA: Inferred from direct assay	24820035	GOA
involved in peptidyl-serine phosphorylation	IGI IGI: Inferred from genetic interaction	25556849	GOA
involved in peptidyl-tyrosine autophosphorylation	IDA IDA: Inferred from direct assay	24327345	GOA
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	9748265	GOA
involved in positive regulation of RNA splicing	IDA IDA: Inferred from direct assay	28377597	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with actin filament	IPI IPI: Inferred from physical interaction	24327345	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15694837	GOA
colocalizes with cytoskeleton	IDA IDA: Inferred from direct assay	24327345	GOA
colocalizes with microtubule	IPI IPI: Inferred from physical interaction	24327345	GOA
colocalizes with neurofilament	IPI IPI: Inferred from physical interaction	24327345	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	25620562	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15694837	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYRK1A Protein Structure

Pkinase

0
200
400
600
763 a.a.

Protein Preferred Names

Protein Names

dual specificity tyrosine-phosphorylation-regulated kinase 1A

MNB/DYRK protein kinase	dual specificity YAK1-related kinase
dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	mnb protein kinase homolog hp86
protein kinase minibrain homolog	serine/threonine kinase MNB
serine/threonine-specific protein kinase

DYRK1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DYRK1A	Q13627	IGF2BP2	Homo sapiens	Q9Y6M1	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	IGF2BP1	Homo sapiens	Q9NZI8	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	IGF2BP3	Homo sapiens	O00425	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	KPRP	Homo sapiens	Q5T749	Validated Y2H	32296183
Intra	DYRK1A	Q13627	ELAVL2	Homo sapiens	Q12926	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	FAM53C	Homo sapiens	Q9NYF3	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	FAM53C	Homo sapiens	Q9NYF3	Y2H Fragment Pooling	35914814
Intra	DYRK1A	Q13627	FAM53C	Homo sapiens	Q9NYF3	TAP	23602568
Intra	DYRK1A	Q13627	TROAP	Homo sapiens	Q12815	TAP	23602568
Intra	DYRK1A	Q13627	TROAP	Homo sapiens	Q12815	Crosslink	26949739
Intra	DYRK1A	Q13627	TRIP12	Homo sapiens	Q14669	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	DYNLL1	Homo sapiens	P63167	Y2H Fragment Pooling	35914814
Intra	DYRK1A	Q13627	DYNLL1	Homo sapiens	P63167	TAP	23602568
Intra	DYRK1A	Q13627	DYNLL1	Homo sapiens	P63167	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	TRAF2	Homo sapiens	Q12933	Y2H Fragment Pooling	35914814
Intra	DYRK1A	Q13627	DCAF7	Homo sapiens	P61962	Pull Down	32707033
Intra	DYRK1A	Q13627	DCAF7	Homo sapiens	P61962	TAP	23602568
Intra	DYRK1A	Q13627	DCAF7	Homo sapiens	P61962	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	FMR1	Homo sapiens	Q06787	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	RB1	Homo sapiens	P06400	BiFC	23602568
Intra	DYRK1A	Q13627	RB1	Homo sapiens	P06400	Pull Down	32707033
Intra	DYRK1A	Q13627	RB1	Homo sapiens	P06400	TAP	23602568
Intra	DYRK1A	Q13627	LZTS2	Homo sapiens	Q9BRK4	Crosslink	26949739
Intra	DYRK1A	Q13627	LZTS2	Homo sapiens	Q9BRK4	TAP	23602568
Intra	DYRK1A	Q13627	LZTS2	Homo sapiens	Q9BRK4	BiFC	23602568
Intra	DYRK1A	Q13627	SATB1	Homo sapiens	Q01826	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	ELAVL3	Homo sapiens	Q14576	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	ZMYND8	Homo sapiens	Q9ULU4	Anti Bait CoIP	36950384
Intra	DYRK1A	Q13627	USP54	Homo sapiens	Q70EL1	Y2H Fragment Pooling	35914814
Intra	DYRK1A	Q13627	RBL1	Homo sapiens	P28749	Pull Down	32707033
Intra	DYRK1A	Q13627	RBL1	Homo sapiens	P28749	TAP	23602568
Intra	DYRK1A	Q13627	RBL1	Homo sapiens	P28749	Anti Tag CoIP	23602568

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Intellectual Developmental Disorder, Autosomal Dominant 7

MRD7	Mental Retardation, Autosomal Dominant 7
Autosomal Dominant Non-Syndromic Intellectual Disability 7	Dyrk1a Syndrome
Autosomal Dominant Intellectual Developmental Disorder 7	Autosomal Dominant Mental Retardation 7
Mental Retardation, Autosomal Dominant, Type 7

Autosomal Dominant Intellectual Developmental Disorder

Autosomal Dominant Mental Retardation	Autosomal Dominant Non-Syndromic Mental Retardation
Autosomal Dominant Non-Syndromic Intellectual Disability	Mental Retardation, Autosomal Dominant

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Chromosomal Duplication Syndrome

Myeloproliferative Syndrome, Transient

Transient Abnormal Myelopoiesis	Transient Myeloproliferative Syndrome
Transient Myeloproliferative Disease	Mst
Tam	Leukemia, Transient, Of Down Syndrome
Tmd	Leukemia, Transient
Transient Leukemia	Transient Leukemia Of Down Syndrome

Acute Dacryocystitis

Dacryocystitis - Acute

Dyrk1a-Related Intellectual Disability Syndrome Due To 21q22.13q22.2 Microdeletion

21q22.13q22.2 Microdeletion Syndrome	Del(21)(Q22.13q22.2)
Monosomy 21q22.13q22.2

Specific Developmental Disorder

Enophthalmos

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Abdominal Obesity-Metabolic Syndrome 3

AOMS3	Central Obesity, Type 2 Diabetes, Hypertension, And Early-Onset Coronary Artery Disease
Obesity, Abdominal, Metabolic Syndrome, Type 3

Chromosomal Disease

Chromosomal Disorders

Congenital Chromosomal Disease

Pick Disease Of Brain

Pick Disease	Pick Disease Of The Brain
Lobar Atrophy Of Brain	Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions
Pick'S Disease	Behavioral Variant Of Frontotemporal Dementia
Dementia In Pick'S Disease	Lobar Atrophy Of The Brain
Bvftd	Bv-Ftd
PIDB	Picks Disease

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Male Urethral Cancer

Male Urethral Malignant Neoplasm

Dyrk1a-Related Intellectual Disability Syndrome

Dyrk1a Syndrome

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Intellectual Disability Syndrome Due To A Dyrk1a Point Mutation

Dyrk1a-Related Intellectual Disability Syndrome Due To A Point Mutation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (61)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115470	CLK-IN-T3	Inhibitor	98.63%	Unkown
HY-105309	GSK-626616	Inhibitor	99.77%	Unkown
HY-132308	DYRK1-IN-1	Inhibitor	99.71%	Unkown
HY-112296	T025		99.64%	Unkown
HY-111380	EHT 1610	Inhibitor	98.16%	Unkown
HY-101298	Paprotrain	Inhibitor	99.87%	Unkown
HY-142295	GNF2133	Inhibitor	98.49%	Unkown
HY-12838	RO5454948	Inhibitor	99.53%	Unkown
HY-146221	Dyrk1A-IN-5	Inhibitor	98.56%	Unkown
HY-15951	ML167	Inhibitor	98.62%	Unkown
HY-108476	INDY	Inhibitor	99.51%	Unkown
HY-15569	NU6102	Inhibitor	99.23%	Unkown
HY-129492	GNF4877	Inhibitor	99.41%	Unkown
HY-101029	MBM-55		99.94%	Unkown
HY-135906	CK2/ERK8-IN-1		≥99.0%	Unkown
HY-111379	EHT 5372	Inhibitor	98.12%	Unkown
HY-117049	Leucettine L41	Inhibitor	98.70%	Unkown
HY-144290	ARN25068	Inhibitor	99.66%	Unkown
HY-147066	Dyrk1A-IN-4	Inhibitor	99.90%	Unkown
HY-147060	Dyrk1A-IN-3	Inhibitor	99.96%	Unkown
HY-110052	TBCA	Inhibitor	99.45%	Unkown
HY-149262	CLK1-IN-3		98.03%	Unkown
HY-156816	ON 108600	Inhibitor	99.73%	Unkown
HY-12828A	KH-CB20	Inhibitor	99.80%	Unkown
HY-128758A	DYRKs-IN-1 hydrochloride	Inhibitor	99.71%	Unkown
HY-34222	7-Deazaguanine	Inhibitor	≥99.0%	Unkown
HY-N12625	(R)-(+)-O-Demethylbuchenavianine	Inhibitor	98.67%	Unkown
HY-RS04095	Dyrk1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-128758	DYRKs-IN-1	Inhibitor	/	Unkown
HY-155723	Leucettinib-92	Inhibitor	/	Unkown
HY-101029A	MBM-55S		/	Unkown
HY-128759	DYRKs-IN-2	Inhibitor	/	Unkown
HY-129449	AnnH31	Inhibitor	99.91%	Unkown
HY-139830	Dyrk1A-IN-1	Inhibitor	/	Unkown
HY-142295A	GNF2133 hydrochloride	Inhibitor	/	Unkown
HY-144614	JH-XVII-10		/	Unkown
HY-144617	JH-XIV-68-3	Inhibitor	/	Unkown
HY-144695	Dyrk1A/α-synuclein-IN-1	Inhibitor	/	Unkown
HY-144696	Dyrk1A/α-synuclein-IN-2	Inhibitor	/	Unkown
HY-144826	ZDWX-25	Inhibitor	/	Unkown
HY-146337	Dyrk1A/B-IN-1	Inhibitor	/	Unkown
HY-146586	Haspin-IN-1	Inhibitor	/	Unkown
HY-146587	Haspin-IN-2	Inhibitor	/	Unkown
HY-147760	Dyrk1A-IN-2	Inhibitor	/	Unkown
HY-150537	AChE/GSK-3β-IN-1	Inhibitor	/	Unkown
HY-152183	FINDY	Inhibitor	/	Unkown
HY-157995	Dyrk1A-IN-7	Inhibitor	/	Unkown
HY-158212	Dyrk1A-IN-8	Inhibitor	/	Unkown
HY-159496	Dyrk1A-IN-10	Inhibitor	/	Unkown
HY-163514	hAChE-IN-8	Inhibitor	/	Unkown
HY-168195	DYR530		/	Unkown
HY-77324S	4-(Trifluoromethyl)aniline-d4	Inhibitor	99.23%	Unkown
HY-N2892	Aristolactam A IIIa	Inhibitor	/	Unkown
HY-P3992	5-FAM-Dyrktide		/	Unkown
HY-RS04094	DYRK1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04096	Dyrk1a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-108475	ProINDY	Inhibitor	/	Unkown
HY-122989	Aristolactam BIII	Inhibitor	/	Unkown
HY-162107	Dyrk1A-IN-6	Inhibitor	/	Unkown
HY-162597	Dyrk1A-IN-9	Inhibitor	/	Unkown
HY-168265	Dyrk1A-IN-11	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DYRK1A	MGD	MGI:1330299
Bos taurus	DYRK1A	VGNC	VGNC:28279
Macaca mulatta	DYRK1A	VGNC	VGNC:72015
Canis familiaris	DYRK1A	VGNC	VGNC:40155
Rattus norvegicus	DYRK1A	RGD	RGD:2528
Felis catus	DYRK1A	VGNC	VGNC:61685
Others	DYRK1A	NCBI

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