CGRRF1 - cell growth regulator with ring finger domain 1 Gene

Homo sapiens

Also known as CGR19; RNF197

Gene ID: 10668 | Gene type: protein coding

About CGRRF1

Cytogenetic location: 14q22.2 Genomic coordinates (GRCh38): 14:54,509,906-54,539,292 (from NCBI)

This gene has 11 transcripts (splice variants) and 220 orthologues. Ubiquitous expression in testis (RPKM 10.6), thyroid (RPKM 6.6) and 25 other tissues.

Summary

Predicted to enable metal ion binding activity. Predicted to be involved in negative regulation of cell growth. Located in endoplasmic reticulum and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CGRRF1 Products(1)

mRNA	Protein	Name
NM_006568.3	NP_006559.1	cell growth regulator with RING finger domain protein 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	27485036	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CGRRF1 Protein Structure

zf-C3HC4_3

0
100
200
300
332 a.a.

Protein Preferred Names

Protein Names

cell growth regulator with RING finger domain protein 1

RING finger protein 197

CGRRF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CGRRF1	Q99675	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	CGRRF1	Q99675	SLC30A3	Homo sapiens	Q99726	Validated Y2H	32296183
Intra	CGRRF1	Q99675	PGAP2	Homo sapiens	Q9UHJ9-5	Validated Y2H	32296183
Intra	CGRRF1	Q99675	LNPEP	Homo sapiens	Q9UIQ6-2	Validated Y2H	32296183
Intra	CGRRF1	Q99675	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	CGRRF1	Q99675	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	CGRRF1	Q99675	SUSD3	Homo sapiens	Q96L08	Y2H Prey Pooling	32296183
Intra	CGRRF1	Q99675	SUSD3	Homo sapiens	Q96L08	Y2H Array	32296183
Intra	CGRRF1	Q99675	MARCHF5	Homo sapiens	Q9NX47	Validated Y2H	32296183
Intra	CGRRF1	Q99675	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	CGRRF1	Q99675	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	CGRRF1	Q99675	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	CGRRF1	Q99675	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	CGRRF1	Q99675	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	CGRRF1	Q99675	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	CGRRF1	Q99675	KLRC1	Homo sapiens	P26715	Y2H Prey Pooling	32296183
Intra	CGRRF1	Q99675	KLRC1	Homo sapiens	P26715	Y2H Array	32296183
Intra	CGRRF1	Q99675	RHBDD1	Homo sapiens	Q8TEB9	Y2H Prey Pooling	32296183
Intra	CGRRF1	Q99675	RHBDD1	Homo sapiens	Q8TEB9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02588	CGRRF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CGRRF1	VGNC	VGNC:39185
Bos taurus	CGRRF1	VGNC	VGNC:27260
Rattus norvegicus	CGRRF1	RGD	RGD:620803
Felis catus	CGRRF1	VGNC	VGNC:104367
Macaca mulatta	CGRRF1	VGNC	VGNC:84322
Mus musculus	CGRRF1	MGD	MGI:1916368

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