2. Gene
  3. NUDC - nuclear distribution C, dynein complex regulator Gene

NUDC - nuclear distribution C, dynein complex regulator Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HNUDC; MNUDC; NPD011

Gene ID: 10726 | Gene type: protein coding

About NUDC

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,900,161-26,946,871 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 27.7), adrenal (RPKM 27.5) and 25 other tissues.

Summary

This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]

NUDC Products(1)

mRNA Protein Name
NM_006600.4 NP_006591.1 nuclear migration protein nudC
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22159412 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mitotic metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
25789526 GOA
involved in mitotic spindle organization IMP
IMP: Inferred from mutant phenotype
25789526 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25468996 GOA
located in midbody IDA
IDA: Inferred from direct assay
25789526 GOA
located in mitotic spindle IDA
IDA: Inferred from direct assay
25789526 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDC Protein Structure

Nudc_N

Nudc_N: N-terminal conserved domain of Nudc. (8 - 60)

CS

CS: CS domain (170 - 247)

  • 0
  • 100
  • 200
  • 300
  • 331 a.a.
Protein Preferred Names Protein Names

nuclear migration protein nudC

nuclear distribution C homolog

NUDC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra NUDC Q9Y266 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra NUDC Q9Y266 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra NUDC Q9Y266 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra NUDC Q9Y266 DYNC2I1 Homo sapiens Q8WVS4
TAP
27173435
Intra NUDC Q9Y266 POC1A Homo sapiens Q8NBT0
Lumier
25036637
Intra NUDC Q9Y266 GIPC1 Homo sapiens O14908-2
Y2H Array
32814053
Intra NUDC Q9Y266 GIPC1 Homo sapiens O14908-2
Y2H Pooling
32814053
Intra NUDC Q9Y266 GIPC1 Homo sapiens O14908-2
Validated Y2H
32814053
Intra NUDC Q9Y266 DNAJA2 Homo sapiens O60884
Lumier
25036637
Intra NUDC Q9Y266 DNAJA2 Homo sapiens O60884
Anti Tag CoIP
25036637
Intra NUDC Q9Y266 EML1 Homo sapiens O00423
Lumier
25036637
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NUDC Proteins

Cat. No. Product Name Accession Purity
HY-P75947 NUDC Protein, Human (HEK293, His) Q9Y266 (M1-N331) ≥95%

Related Diseases

Diseases Alias
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Lissencephaly

Pachygyria

Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum

Macrogyria
3mc Syndrome 1

Oculopalatoskeletal Syndrome

3MC1

Craniosynostosis With Lid Anomalies

Michels Syndrome, Formerly

Michels Syndrome

3mc Syndrome, Type 1
Hermansky-Pudlak Syndrome 3

HPS3

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

Delta Storage Pool Disease

Hermansky-Pudlak Syndrome, Type 3

Platelet Storage Pool Deficiency

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Lissencephaly 1

LIS1

Classic Lissencephaly

Ils

Subcortical Laminar Heterotopia

Lissencephaly Due To Lis1 Mutation

Lissencephaly Sequence, Isolated

Lissencephaly, Classic

Pafah1b1-Related Lissencephaly

Classical Lissencephaly

Lissencephaly Type 1

Lissencephaly-1

Subcortical Band Heterotopia

Double Cortex

Lissencephaly Classic

Lissencephaly Sequence Isolated

Isolated Lissencephaly Sequence

Type 1 Lissencephaly

Lissencephaly Syndrome Type 1

SBH

Sclh

Lissencephaly, Type 1

Type I Lissencephaly
Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome

Mds

MDLS

Miller Dieker Syndrome

Classical Lissencephaly Syndrome

Lissencephaly Due To 17p13.3 Deletion

Monosomy 17p13.3

Telomeric Deletion 17p

Classical Lissencephaly
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09657 NUDC Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NUDC VGNC VGNC:68588
Macaca mulatta NUDC VGNC VGNC:100021
Mus musculus NUDC MGD MGI:106014
Rattus norvegicus NUDC RGD RGD:3215
Canis familiaris NUDC VGNC VGNC:44021
Bos taurus NUDC VGNC VGNC:32321
Others NUDC NCBI