PTGES3 - prostaglandin E synthase 3 Gene

Homo sapiens

Also known as P23; TEBP; cPGES

Gene ID: 10728 | Gene type: protein coding

About PTGES3

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,663,349-56,688,284 (from NCBI)

This gene has 7 transcripts (splice variants), 283 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 50.6), endometrium (RPKM 43.3) and 25 other tissues.

Summary

This gene encodes an Enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]

PTGES3 Products(6)

mRNA	Protein	Name
NM_001282601.2	NP_001269530.1	prostaglandin E synthase 3 isoform b
NM_001282602.2	NP_001269531.1	prostaglandin E synthase 3 isoform c
NM_001282603.2	NP_001269532.1	prostaglandin E synthase 3 isoform d
NM_001282604.2	NP_001269533.1	prostaglandin E synthase 3 isoform e
NM_001282605.2	NP_001269534.1	prostaglandin E synthase 3 isoform f
NM_006601.7	NP_006592.3	prostaglandin E synthase 3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA polymerase binding	IPI IPI: Inferred from physical interaction	10197982	GOA
enables Hsp90 protein binding	IPI IPI: Inferred from physical interaction	10543959	GOA
enables prostaglandin-E synthase activity	IDA IDA: Inferred from direct assay	10922363	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9817749	GOA
enables telomerase activity	IDA IDA: Inferred from direct assay	12135483	GOA
enables unfolded protein binding	IDA IDA: Inferred from direct assay	12077419	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chaperone cofactor-dependent protein refolding	IDA IDA: Inferred from direct assay	12853476	GOA
involved in chaperone-mediated protein complex assembly	IMP IMP: Inferred from mutant phenotype	10811660	GOA
involved in positive regulation of telomere maintenance via telomerase	IDA IDA: Inferred from direct assay	19740745	GOA
involved in prostaglandin biosynthetic process	IDA IDA: Inferred from direct assay	10922363	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	10543959	GOA
involved in telomerase holoenzyme complex assembly	IDA IDA: Inferred from direct assay	10197982	GOA
acts upstream of positive effect telomere maintenance via telomerase	IDA IDA: Inferred from direct assay	10197982	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein folding chaperone complex	IDA IDA: Inferred from direct assay	29127155	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	10543959	GOA
part of telomerase holoenzyme complex	IDA IDA: Inferred from direct assay	12135483	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGES3 Protein Structure

0
100
160 a.a.

Protein Preferred Names

Protein Names

prostaglandin E synthase 3

Hsp90 co-chaperone

PTGES3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTGES3	Q15185	POLR3A	Homo sapiens	O14802	Lumier	25036637
Intra	PTGES3	Q15185	POLR3A	Homo sapiens	O14802	Anti Tag CoIP	33961781
Intra	PTGES3	Q15185	POLR3A	Homo sapiens	O14802	Anti Tag CoIP	35271311
Intra	PTGES3	Q15185	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	35271311
Intra	PTGES3	Q15185	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	33961781
Intra	PTGES3	Q15185	HSP90AA1	Homo sapiens	P07900	Y2H	21988832
Intra	PTGES3	Q15185	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	35271311
Intra	PTGES3	Q15185	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	33961781
Intra	PTGES3	Q15185	URI1	Homo sapiens	O94763	Anti Tag CoIP	35271311
Intra	PTGES3	Q15185	URI1	Homo sapiens	O94763	Lumier	25036637
Intra	PTGES3	Q15185	URI1	Homo sapiens	O94763	Anti Tag CoIP	33961781
Intra	PTGES3	Q15185	AGO2	Homo sapiens	Q9UKV8	Anti Bait CoIP	23741051

Cross: Cross-species interaction Intra: Intraspecies interaction

PTGES3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83386	p23 Antibody (YA3131)	WB, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Ciliary Dyskinesia, Primary, 25

Primary Ciliary Dyskinesia 25	CILD25
Primary Ciliary Dyskinesia 25 With Or Without Situs Inversus	Ciliary Dyskinesia, Primary, 25, With Or Without Situs Inversus
Dyskinesia, Ciliary, Primary, Type 25

Gastroesophageal Reflux

Gastroesophageal Reflux Disease	Gerd
GER	Gastroesophageal Reflux, Pediatric
Acid Reflux	Gastresophageal Reflux
Gastro-Esophageal Reflux	Gerd - Gastro-Esophageal Reflux Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11381	PTGES3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PTGES3	RGD	RGD:1561913
Bos taurus	PTGES3	VGNC	VGNC:33507
Mus musculus	PTGES3	MGD	MGI:1929282
Macaca mulatta	PTGES3	VGNC	VGNC:97814
Canis familiaris	PTGES3	VGNC	VGNC:54535

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