URI1 - URI1 prefoldin like chaperone Gene

Homo sapiens

Also known as RMP; URI; NNX3; C19orf2; PPP1R19

Gene ID: 8725 | Gene type: protein coding

About URI1

Cytogenetic location: 19q12 Genomic coordinates (GRCh38): 19:29,923,657-30,016,612 (from NCBI)

This gene has 13 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in thyroid (RPKM 23.9), testis (RPKM 18.7) and 25 other tissues.

Summary

This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian Cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]

URI1 Products(2)

mRNA	Protein	Name
NM_001252641.2	NP_001239570.1	unconventional prefoldin RPB5 interactor 1 isoform c
NM_003796.3	NP_003787.2	unconventional prefoldin RPB5 interactor 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II complex binding	IDA IDA: Inferred from direct assay	9819440	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	21730289	GOA
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	20864032	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12737519	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	12737519	GOA
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	9819440	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	17936702	GOA
involved in cellular response to steroid hormone stimulus	IDA IDA: Inferred from direct assay	21730289	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	17936702	GOA
involved in negative regulation of phosphatase activity	IMP IMP: Inferred from mutant phenotype	17936702	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12737519	GOA
involved in regulation of cell growth	IDA IDA: Inferred from direct assay	21730289	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9819440	GOA
involved in response to virus	IMP IMP: Inferred from mutant phenotype	9819440	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RPAP3/R2TP/prefoldin-like complex	IPI IPI: Inferred from physical interaction	31738558	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15367675	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15367675	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

URI1 Protein Structure

Prefoldin

0
100
200
300
400
459 a.a.

Protein Preferred Names

Protein Names

unconventional prefoldin RPB5 interactor 1

RNA polymerase II subunit 5-mediating protein

URI1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	URI1	O94763	GTF2F2	Homo sapiens	P13984	Pull Down	12737519
Cross	URI1	O94763	Esr1	Mus musculus	P19785	Anti Bait CoIP	25453901
Intra	URI1	O94763	PPP1CC	Homo sapiens	P36873	Anti Bait CoIP	27505673
Intra	URI1	O94763	PPP1CC	Homo sapiens	P36873	Anti Bait CoIP	21397856
Intra	URI1	O94763	RPAP3	Homo sapiens	Q9H6T3	Lumier	25036637
Intra	URI1	O94763	PFDN2	Homo sapiens	Q9UHV9	Anti Bait CoIP	15923622
Intra	URI1	O94763	POLR2E	Homo sapiens	P19388	Anti Bait CoIP	15923622
Intra	URI1	O94763	GTF2F1	Homo sapiens	P35269	Pull Down	12737519
Intra	URI1	O94763	OGT	Homo sapiens	O15294	Pull Down	27505673
Intra	URI1	O94763	OGT	Homo sapiens	O15294	Anti Bait CoIP	27505673
Cross	URI1	O94763	Ahr	Mus musculus	P30561	Anti Bait CoIP	25453901

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Hypermobility Of Coccyx

Coccygeal Hypermobility Syndrome

Hypermobility Of The Coccyx

Klippel-Feil Syndrome 3

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Neurodegeneration With Brain Iron Accumulation 4

NBIA4	Mpan
Mitochondrial Protein-Associated Neurodegeneration	Nbia Due To C19orf12 Mutation
Neurodegeneration With Brain Iron Accumulation Due To C19orf12 Mutation	Neurodegeneration With Brain Iron Accumulation Type 4
Mitochondrial Membrane Protein Associated Neurodegeneration	Neurodegeneration, With Brain Iron Accumulation, Type 4

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0161A	Chlophedianol hydrochloride		99.62%	Unkown
HY-A0161	Chlophedianol		/	Unkown

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0161S	Chlophedianol-13C6		/	Unkown
HY-RS15507	URI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	URI1	VGNC	VGNC:36698
Mus musculus	URI1	MGD	MGI:1342294
Macaca mulatta	URI1	VGNC	VGNC:78918
Canis familiaris	URI1	VGNC	VGNC:48166
Felis catus	URI1	VGNC	VGNC:66853
Rattus norvegicus	URI1	RGD	RGD:1310358

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