2. Gene
  3. RAI2 - retinoic acid induced 2 Gene

RAI2 - retinoic acid induced 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 10742 | Gene type: protein coding

About RAI2

Cytogenetic location: Xp22.13 Genomic coordinates (GRCh38): X:17,800,049-17,861,298 (from NCBI)

This gene has 6 transcripts (splice variants), 169 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 19.5), ovary (RPKM 15.2) and 23 other tissues.

Summary

Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this retinoic acid-induced gene has not yet been determined but it may play a role in development. The chromosomal location of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked cognitive disability, oral-facial-digital syndrome, and Fried syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

RAI2 Products(4)

mRNA Protein Name
NM_001172732.2 NP_001166203.2 retinoic acid-induced protein 2 isoform 2
NM_001172739.2 NP_001166210.2 retinoic acid-induced protein 2 isoform 1
NM_001172743.2 NP_001166214.2 retinoic acid-induced protein 2 isoform 1
NM_021785.6 NP_068557.4 retinoic acid-induced protein 2 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAI2 Protein Structure

SOBP

SOBP: Sine oculis-binding protein (106 - 250)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 530 a.a.
Protein Preferred Names Protein Names

retinoic acid-induced protein 2

RAI2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RAI2 Q9Y5P3 CTBP2 Homo sapiens P56545-3
Validated Y2H
25416956
Intra
RAI2 Q9Y5P3 GTF3C3 Homo sapiens Q9Y5Q9
Validated Y2H
32814053
Intra
RAI2 Q9Y5P3 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Array
32814053
Intra
RAI2 Q9Y5P3 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Pooling
32814053
Intra
RAI2 Q9Y5P3 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
RAI2 Q9Y5P3 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
RAI2 Q9Y5P3 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
RAI2 Q9Y5P3 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
RAI2 Q9Y5P3 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
RAI2 Q9Y5P3 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
RAI2 Q9Y5P3 NEFL Homo sapiens P07196
Validated Y2H
32814053
Intra
RAI2 Q9Y5P3 NEFL Homo sapiens P07196
Y2H Array
32814053
Intra
RAI2 Q9Y5P3 NEFL Homo sapiens P07196
Y2H Pooling
32814053
Intra
RAI2 Q9Y5P3 FHL2 Homo sapiens Q14192
Y2H Array
31515488
Intra
RAI2 Q9Y5P3 FHL2 Homo sapiens Q14192
Y2H Prey Pooling
25416956
Intra
RAI2 Q9Y5P3 UBQLN4 Homo sapiens Q9NRR5
Y2H Array
16713569
Intra
RAI2 Q9Y5P3 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
RAI2 Q9Y5P3 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
RAI2 Q9Y5P3 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
RAI2 Q9Y5P3 CTBP2 Homo sapiens P56545
Validated Y2H
25416956
Intra
RAI2 Q9Y5P3 SGTB Homo sapiens Q96EQ0
Y2H Array
29892012
Intra
RAI2 Q9Y5P3 SGTB Homo sapiens Q96EQ0
Y2H Pooling
16189514
Intra
RAI2 Q9Y5P3 SGTB Homo sapiens Q96EQ0
Validated Y2H
25416956
Intra
RAI2 Q9Y5P3 SGTB Homo sapiens Q96EQ0
Y2H Array
25416956
Intra
RAI2 Q9Y5P3 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra
RAI2 Q9Y5P3 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra
RAI2 Q9Y5P3 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nance-Horan Syndrome

NHS

Cataract-Dental Syndrome

Cataract, X-Linked, With Hutchinsonian Teeth

Mesiodens-Cataract Syndrome

Cataract X-Linked With Hutchinsonian Teeth

Cataract Dental Syndrome

Mesiodens Cataract Syndrome
Decubitus Ulcer

Pressure Ulcer

Pressure Sores

Pressure Ulcers

Bedsore

Decubitus Ulcer

Decubitus Ulcer Any Site
Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities
Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11626 RAI2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RAI2 MGD MGI:1344378
Macaca mulatta RAI2 VGNC VGNC:76652
Rattus norvegicus RAI2 RGD RGD:1560139
Bos taurus RAI2 VGNC VGNC:33697
Felis catus RAI2 VGNC VGNC:69225