2. Gene
  3. TOB2 - transducer of ERBB2, 2 Gene

TOB2 - transducer of ERBB2, 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TOB4; TOBL; APRO5; TROB2

Gene ID: 10766 | Gene type: protein coding

About TOB2

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,433,494-41,446,801 (from NCBI)

This gene has 2 transcripts (splice variants), 189 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 15.5), thyroid (RPKM 14.3) and 25 other tissues.

Summary

TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]

TOB2 Products(1)

mRNA Protein Name
NM_016272.4 NP_057356.1 protein Tob2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19838187 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOB2 Protein Structure

BTG

BTG: BTG family (1 - 114)

PAM2

PAM2: Ataxin-2 C-terminal region (129 - 144)

PAM2

PAM2: Ataxin-2 C-terminal region (248 - 264)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
Protein Preferred Names Protein Names

protein Tob2

protein Tob4

TOB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross TOB2 Q14106 Cnot7 Mus musculus Q60809
Anti Tag CoIP
19838187
Cross TOB2 Q14106 Cnot7 Mus musculus Q60809
Anti Tag CoIP
23340509
Intra TOB2 Q14106 CNOT7 Homo sapiens Q9UIV1
Y2H Prey Pooling
32296183
Intra TOB2 Q14106 CNOT7 Homo sapiens Q9UIV1
Validated Y2H
32296183
Intra TOB2 Q14106 CNOT7 Homo sapiens Q9UIV1
Y2H Array
32296183
Intra TOB2 Q14106 CNOT7 Homo sapiens Q9UIV1
Y2H Prey Pooling
25416956
Intra TOB2 Q14106 BHLHE40 Homo sapiens O14503
Validated Y2H
25416956
Intra TOB2 Q14106 BHLHE40 Homo sapiens O14503
Y2H Array
25416956
Intra TOB2 Q14106 CNOT8 Homo sapiens Q9UFF9
Y2H Prey Pooling
25416956
Intra TOB2 Q14106 CNOT8 Homo sapiens Q9UFF9
Validated Y2H
25416956
Intra TOB2 Q14106 CEP76 Homo sapiens Q8TAP6
Validated Y2H
25416956
Intra TOB2 Q14106 PABPC1 Homo sapiens P11940
Anti Tag CoIP
23340509
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Basilar Artery Insufficiency

Basilar Artery Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14873 TOB2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TOB2 VGNC VGNC:36213
Canis familiaris TOB2 VGNC VGNC:54378
Felis catus TOB2 VGNC VGNC:66439
Rattus norvegicus TOB2 RGD RGD:1359722
Mus musculus TOB2 MGD MGI:1888525
Macaca mulatta TOB2 VGNC VGNC:78614