CNOT8 - CCR4-NOT transcription complex subunit 8 Gene

Homo sapiens

Also known as CAF1; POP2; CALIF; Caf1b; hCAF1

Gene ID: 9337 | Gene type: protein coding

About CNOT8

Cytogenetic location: 5q33.2 Genomic coordinates (GRCh38): 5:154,858,249-154,876,792 (from NCBI)

This gene has 25 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 22.1), lymph node (RPKM 19.7) and 25 other tissues.

Summary

Enables poly(A)-specific ribonuclease activity. Involved in exonucleolytic catabolism of deadenylated mRNA and positive regulation of cell population proliferation. Located in nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

CNOT8 Products(9)

mRNA	Protein	Name
NM_001301073.2	NP_001288002.1	CCR4-NOT transcription complex subunit 8 isoform 1
NM_001301074.2	NP_001288003.1	CCR4-NOT transcription complex subunit 8 isoform 2
NM_001301075.2	NP_001288004.1	CCR4-NOT transcription complex subunit 8 isoform 3
NM_001301077.2	NP_001288006.1	CCR4-NOT transcription complex subunit 8 isoform 3
NM_001301080.2	NP_001288009.1	CCR4-NOT transcription complex subunit 8 isoform 3
NM_001301082.1	NP_001288011.1	CCR4-NOT transcription complex subunit 8 isoform 3
NM_001301083.1	NP_001288012.1	CCR4-NOT transcription complex subunit 8 isoform 3
NM_001301086.2	NP_001288015.1	CCR4-NOT transcription complex subunit 8 isoform 4
NM_004779.6	NP_004770.4	CCR4-NOT transcription complex subunit 8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5'-RNA exonuclease activity	IDA IDA: Inferred from direct assay	15769875	GOA
enables poly(A)-specific ribonuclease activity	IDA IDA: Inferred from direct assay	15769875	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10637334	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	20065043	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19605561	GOA
involved in positive regulation of mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	22977175	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CCR4-NOT complex	IDA IDA: Inferred from direct assay	19558367	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9820826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNOT8 Protein Structure

CAF1

0
100
200
292 a.a.

Protein Preferred Names

Protein Names

CCR4-NOT transcription complex subunit 8

CAF1-like protein

CNOT8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CNOT8	Q9UFF9	BTG1	Homo sapiens	Q6IBC8	Validated Y2H	25416956
Intra	CNOT8	Q9UFF9	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	17452450
Intra	CNOT8	Q9UFF9	BTG2	Homo sapiens	P78543	Validated Y2H	25416956
Intra	CNOT8	Q9UFF9	BTG2	Homo sapiens	P78543	Y2H	11136725
Intra	CNOT8	Q9UFF9	BTG2	Homo sapiens	P78543	Pull Down	11136725
Intra	CNOT8	Q9UFF9	CNOT1	Homo sapiens	A5YKK6	Anti Bait CoIP	16778766
Intra	CNOT8	Q9UFF9	CNOT1	Homo sapiens	A5YKK6	Anti Bait CoIP	17353931
Intra	CNOT8	Q9UFF9	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	22977175
Intra	CNOT8	Q9UFF9	CNOT1	Homo sapiens	A5YKK6	Y2H	10637334
Intra	CNOT8	Q9UFF9	CNOT6	Homo sapiens	Q9ULM6	Y2H	11747467
Intra	CNOT8	Q9UFF9	CNOT6	Homo sapiens	Q9ULM6	Anti Tag CoIP	17452450
Intra	CNOT8	Q9UFF9	TOB2	Homo sapiens	Q14106	Y2H Array	25416956
Intra	CNOT8	Q9UFF9	BTG1	Homo sapiens	P62324	Pull Down	11136725
Intra	CNOT8	Q9UFF9	BTG1	Homo sapiens	P62324	Y2H Array	31515488
Intra	CNOT8	Q9UFF9	CNOT2	Homo sapiens	Q9NZN8	Anti Bait CoIP	16778766
Intra	CNOT8	Q9UFF9	CNOT3	Homo sapiens	O75175	Anti Bait CoIP	16778766

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02908	CNOT8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CNOT8	VGNC	VGNC:71391
Mus musculus	CNOT8	MGD	MGI:1916375
Bos taurus	CNOT8	VGNC	VGNC:27523
Rattus norvegicus	CNOT8	RGD	RGD:1306401
Felis catus	CNOT8	VGNC	VGNC:68960
Canis familiaris	CNOT8	VGNC	VGNC:39419

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