CNOT7 - CCR4-NOT transcription complex subunit 7 Gene

Homo sapiens

Also known as CAF1; CAF-1; Caf1a; hCAF-1

Gene ID: 29883 | Gene type: protein coding

About CNOT7

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:17,224,966-17,246,857 (from NCBI)

This gene has 13 transcripts (splice variants), 222 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 13.0), lymph node (RPKM 9.7) and 25 other tissues.

Summary

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]

CNOT7 Products(16)

mRNA	Protein	Name
NM_001322087.2	NP_001309016.1	CCR4-NOT transcription complex subunit 7 isoform 2
NM_001322088.2	NP_001309017.1	CCR4-NOT transcription complex subunit 7 isoform 2
NM_001322089.2	NP_001309018.1	CCR4-NOT transcription complex subunit 7 isoform 2
NM_001322090.2	NP_001309019.1	CCR4-NOT transcription complex subunit 7 isoform 1
NM_001322091.2	NP_001309020.1	CCR4-NOT transcription complex subunit 7 isoform 1
NM_001322092.2	NP_001309021.1	CCR4-NOT transcription complex subunit 7 isoform 1
NM_001322093.2	NP_001309022.1	CCR4-NOT transcription complex subunit 7 isoform 3
NM_001322094.2	NP_001309023.1	CCR4-NOT transcription complex subunit 7 isoform 4
NM_001322095.2	NP_001309024.1	CCR4-NOT transcription complex subunit 7 isoform 5
NM_001322096.2	NP_001309025.1	CCR4-NOT transcription complex subunit 7 isoform 5
NM_001322097.2	NP_001309026.1	CCR4-NOT transcription complex subunit 7 isoform 5
NM_001322098.2	NP_001309027.1	CCR4-NOT transcription complex subunit 7 isoform 6
NM_001322099.2	NP_001309028.1	CCR4-NOT transcription complex subunit 7 isoform 6
NM_001322100.2	NP_001309029.1	CCR4-NOT transcription complex subunit 7 isoform 6
NM_013354.7	NP_037486.2	CCR4-NOT transcription complex subunit 7 isoform 1
NM_054026.4	NP_473367.2	CCR4-NOT transcription complex subunit 7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5'-RNA exonuclease activity	IDA IDA: Inferred from direct assay	15769875	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	23386060	GOA
enables RNA exonuclease activity	IDA IDA: Inferred from direct assay	19276069	GOA
enables poly(A)-specific ribonuclease activity	IDA IDA: Inferred from direct assay	15769875	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9820826	GOA
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	23386060	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in deadenylation-dependent decapping of nuclear-transcribed mRNA	IDA IDA: Inferred from direct assay	31439799	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	23386060	GOA
involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	20065043	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	23386060	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	19276069	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25038453	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23386060	GOA
involved in nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: Inferred from direct assay	21336257	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19605561	GOA
involved in positive regulation of mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	23386060	GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP IMP: Inferred from mutant phenotype	21278420	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IMP IMP: Inferred from mutant phenotype	21278420	GOA
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	23386060	GOA
involved in regulation of tyrosine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	23386060	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CCR4-NOT complex	IDA IDA: Inferred from direct assay	19558367	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	23386060	GOA
is active in intracellular non-membrane-bounded organelle	IDA IDA: Inferred from direct assay	31439799	GOA
located in nuclear speck	IMP IMP: Inferred from mutant phenotype	23386060	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9820826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNOT7 Protein Structure

CAF1

0
100
200
285 a.a.

Protein Preferred Names

Protein Names

CCR4-NOT transcription complex subunit 7

BTG1-binding factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02907	CNOT7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CNOT7	VGNC	VGNC:61030
Canis familiaris	CNOT7	VGNC	VGNC:39418
Rattus norvegicus	CNOT7	RGD	RGD:1305313
Mus musculus	CNOT7	MGD	MGI:1298230
Macaca mulatta	CNOT7	VGNC	VGNC:83990
Bos taurus	CNOT7	VGNC	VGNC:27522

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