CNOT7 - CCR4-NOT transcription complex subunit 7 Gene

Homo sapiens

Also known as CAF1; CAF-1; Caf1a; hCAF-1

Gene ID: 29883 | Gene type: protein coding

About CNOT7

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:17,224,966-17,246,857 (from NCBI)

This gene has 13 transcripts (splice variants), 222 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 13.0), lymph node (RPKM 9.7) and 25 other tissues.

Summary

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]

CNOT7 Products(16)

mRNA	Protein	Name
NM_001322087.2	NP_001309016.1	CCR4-NOT transcription complex subunit 7 isoform 2
NM_001322088.2	NP_001309017.1	CCR4-NOT transcription complex subunit 7 isoform 2
NM_001322089.2	NP_001309018.1	CCR4-NOT transcription complex subunit 7 isoform 2
NM_001322090.2	NP_001309019.1	CCR4-NOT transcription complex subunit 7 isoform 1
NM_001322091.2	NP_001309020.1	CCR4-NOT transcription complex subunit 7 isoform 1
NM_001322092.2	NP_001309021.1	CCR4-NOT transcription complex subunit 7 isoform 1
NM_001322093.2	NP_001309022.1	CCR4-NOT transcription complex subunit 7 isoform 3
NM_001322094.2	NP_001309023.1	CCR4-NOT transcription complex subunit 7 isoform 4
NM_001322095.2	NP_001309024.1	CCR4-NOT transcription complex subunit 7 isoform 5
NM_001322096.2	NP_001309025.1	CCR4-NOT transcription complex subunit 7 isoform 5
NM_001322097.2	NP_001309026.1	CCR4-NOT transcription complex subunit 7 isoform 5
NM_001322098.2	NP_001309027.1	CCR4-NOT transcription complex subunit 7 isoform 6
NM_001322099.2	NP_001309028.1	CCR4-NOT transcription complex subunit 7 isoform 6
NM_001322100.2	NP_001309029.1	CCR4-NOT transcription complex subunit 7 isoform 6
NM_013354.7	NP_037486.2	CCR4-NOT transcription complex subunit 7 isoform 1
NM_054026.4	NP_473367.2	CCR4-NOT transcription complex subunit 7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5'-RNA exonuclease activity	IDA IDA: Inferred from direct assay	15769875	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	23386060	GOA
enables RNA exonuclease activity	IDA IDA: Inferred from direct assay	19276069	GOA
enables poly(A)-specific ribonuclease activity	IDA IDA: Inferred from direct assay	15769875	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9820826	GOA
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	23386060	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in deadenylation-dependent decapping of nuclear-transcribed mRNA	IDA IDA: Inferred from direct assay	31439799	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	23386060	GOA
involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	20065043	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	23386060	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	19276069	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25038453	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23386060	GOA
involved in nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: Inferred from direct assay	21336257	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19605561	GOA
involved in positive regulation of mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	23386060	GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP IMP: Inferred from mutant phenotype	21278420	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IMP IMP: Inferred from mutant phenotype	21278420	GOA
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	23386060	GOA
involved in regulation of tyrosine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	23386060	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CCR4-NOT complex	IDA IDA: Inferred from direct assay	19558367	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	23386060	GOA
is active in intracellular non-membrane-bounded organelle	IDA IDA: Inferred from direct assay	31439799	GOA
located in nuclear speck	IMP IMP: Inferred from mutant phenotype	23386060	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9820826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNOT7 Protein Structure

CAF1

0
100
200
285 a.a.

Protein Preferred Names

Protein Names

CCR4-NOT transcription complex subunit 7

BTG1-binding factor 1

CNOT7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CNOT7	Q9UIV1	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	28514442
Intra	CNOT7	Q9UIV1	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	33961781
Intra	CNOT7	Q9UIV1	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	17452450
Intra	CNOT7	Q9UIV1	CNOT1	Homo sapiens	A5YKK6	GMS	22977175
Intra	CNOT7	Q9UIV1	CNOT1	Homo sapiens	A5YKK6	Pull Down	22977175
Intra	CNOT7	Q9UIV1	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	22977175
Intra	CNOT7	Q9UIV1	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	33961781
Intra	CNOT7	Q9UIV1	CNOT6	Homo sapiens	Q9ULM6	Anti Tag CoIP	33961781
Intra	CNOT7	Q9UIV1	TOB2	Homo sapiens	Q14106	Anti Tag CoIP	28514442
Intra	CNOT7	Q9UIV1	TOB2	Homo sapiens	Q14106	Y2H Array	25416956
Intra	CNOT7	Q9UIV1	TOB2	Homo sapiens	Q14106	Anti Tag CoIP	33961781
Intra	CNOT7	Q9UIV1	TOB2	Homo sapiens	Q14106	Validated Y2H	25416956
Intra	CNOT7	Q9UIV1	PATL1	Homo sapiens	Q86TB9	Anti Tag CoIP	20584987
Intra	CNOT7	Q9UIV1	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	21981923
Intra	CNOT7	Q9UIV1	TOB1	Homo sapiens	P50616	X-Ray Diffraction	19276069
Intra	CNOT7	Q9UIV1	TOB1	Homo sapiens	P50616	Y2H Array	31515488
Intra	CNOT7	Q9UIV1	TOB1	Homo sapiens	P50616	Anti Tag CoIP	33961781
Intra	CNOT7	Q9UIV1	TOB1	Homo sapiens	P50616	ITC	20595394
Intra	CNOT7	Q9UIV1	TOB1	Homo sapiens	P50616	Anti Tag CoIP	28514442
Intra	CNOT7	Q9UIV1	TOB1	Homo sapiens	P50616	Anti Tag CoIP	21336257
Intra	CNOT7	Q9UIV1	TOB1	Homo sapiens	P50616	TAP	18377426
Intra	CNOT7	Q9UIV1	BTG1	Homo sapiens	P62324	Y2H	11136725

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02907	CNOT7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CNOT7	VGNC	VGNC:61030
Canis familiaris	CNOT7	VGNC	VGNC:39418
Rattus norvegicus	CNOT7	RGD	RGD:1305313
Mus musculus	CNOT7	MGD	MGI:1298230
Macaca mulatta	CNOT7	VGNC	VGNC:83990
Bos taurus	CNOT7	VGNC	VGNC:27522

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