PABPC1 - poly(A) binding protein cytoplasmic 1 Gene

Homo sapiens

Also known as PAB1; PABP; PABP1; PABPC2; PABPL1

Gene ID: 26986 | Gene type: protein coding

About PABPC1

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:100,702,916-100,722,088 (from NCBI)

This gene has 40 transcripts (splice variants), 148 orthologues, 24 paralogues and is associated with 73 phenotypes. Ubiquitous expression in esophagus (RPKM 345.6), urinary bladder (RPKM 280.1) and 25 other tissues.

Summary

This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]

PABPC1 Products(1)

mRNA	Protein	Name
NM_002568.4	NP_002559.2	polyadenylate-binding protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	25225333	GOA
enables RNA binding	IPI IPI: Inferred from physical interaction	23041282	GOA
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	16126846	GOA
enables mRNA binding	EXP EXP: Inferred from Experiment	23041282	GOA
enables poly(A) binding	IDA IDA: Inferred from direct assay	16804161	GOA
enables poly(U) RNA binding	IDA IDA: Inferred from direct assay	21984414	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11051545	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in CRD-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	11051545	GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: Inferred from direct assay	11051545	GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: Inferred from direct assay	18447585	GOA
involved in positive regulation of cytoplasmic translation	IDA IDA: Inferred from direct assay	11051545	GOA
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	26735137	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cell leading edge	IDA IDA: Inferred from direct assay	28733330	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	28733330	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	15121898	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	21883093	GOA
located in cytosol	IDA IDA: Inferred from direct assay	11051545	GOA
part of mCRD-mediated mRNA stability complex	IPI IPI: Inferred from physical interaction	11051545	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21940797	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PABPC1 Protein Structure

RRM_1

PABP

0
100
200
300
400
500
600
636 a.a.

Protein Preferred Names

Protein Names

polyadenylate-binding protein 1

poly(A) binding protein, cytoplasmic 2

PABPC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PABPC1	P11940	LARP4B	Homo sapiens	Q92615	Phage Display	35044719
Intra	PABPC1	P11940	PABPN1	Homo sapiens	Q86U42	Anti Tag CoIP	23665581
Intra	PABPC1	P11940	TNRC6A	Homo sapiens	Q8NDV7	Anti Bait CoIP	28877994
Intra	PABPC1	P11940	TNRC6A	Homo sapiens	Q8NDV7	Anti Tag CoIP	21063388
Intra	PABPC1	P11940	PAN3	Homo sapiens	Q58A45	Pull Down	17595167
Intra	PABPC1	P11940	PAN3	Homo sapiens	Q58A45	NMR	17595167
Cross	PABPC1	P11940	N	SARS-CoV-2	P0DTC9	Y2H Array	36217030
Intra	PABPC1	P11940	TOB2	Homo sapiens	Q14106	Phage Display	35044719
Intra	PABPC1	P11940	PAIP2	Homo sapiens	Q9BPZ3	NMR	14685257
Intra	PABPC1	P11940	PAIP2	Homo sapiens	Q9BPZ3	Pull Down	14685257
Intra	PABPC1	P11940	PAIP2	Homo sapiens	Q9BPZ3	Anti Bait CoIP	16601676
Intra	PABPC1	P11940	PAIP2	Homo sapiens	Q9BPZ3	FPS	37100772
Intra	PABPC1	P11940	PAIP2	Homo sapiens	Q9BPZ3	ITC	14685257
Intra	PABPC1	P11940	DDX3X	Homo sapiens	O00571	Pull Down	21883093
Intra	PABPC1	P11940	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	PABPC1	P11940	GSPT2	Homo sapiens	Q8IYD1	Pull Down	14685257
Intra	PABPC1	P11940	GSPT2	Homo sapiens	Q8IYD1	Phage Display	35044719
Intra	PABPC1	P11940	GSPT2	Homo sapiens	Q8IYD1	SPR	14685257
Intra	PABPC1	P11940	HNRNPD	Homo sapiens	Q14103-4	Pull Down	16556936
Intra	PABPC1	P11940	NCBP1	Homo sapiens	Q09161	Anti Tag CoIP	23665581
Intra	PABPC1	P11940	TNRC6C	Homo sapiens	Q9HCJ0-1	Anti Tag CoIP	21063388
Intra	PABPC1	P11940	TNRC6C	Homo sapiens	Q9HCJ0	Pull Down	19716330
Intra	PABPC1	P11940	TNRC6C	Homo sapiens	Q9HCJ0	X-Ray Diffraction	20181956
Intra	PABPC1	P11940	TNRC6C	Homo sapiens	Q9HCJ0	NMR	20181956
Intra	PABPC1	P11940	ATXN2	Homo sapiens	Q99700	X-Ray Diffraction	20181956
Intra	PABPC1	P11940	ATXN2	Homo sapiens	Q99700	IF	15663938
Intra	PABPC1	P11940	TOB1	Homo sapiens	P50616	ITC	20595394
Intra	PABPC1	P11940	TOB1	Homo sapiens	P50616	NMR	20595394
Intra	PABPC1	P11940	EIF4E	Homo sapiens	P06730	Anti Tag CoIP	23665581
Intra	PABPC1	P11940	EIF4G1	Homo sapiens	Q04637	ITC	12086624
Intra	PABPC1	P11940	EIF4G1	Homo sapiens	Q04637	CoIP	9857202
Intra	PABPC1	P11940	PAIP1	Homo sapiens	Q9H074	MST	33876849
Intra	PABPC1	P11940	PAIP1	Homo sapiens	Q9H074	Far-WB	11997512
Intra	PABPC1	P11940	PAIP1	Homo sapiens	Q9H074	SPR	11997512
Intra	PABPC1	P11940	PAIP1	Homo sapiens	Q9H074	Pull Down	9548260
Intra	PABPC1	P11940	PAIP1	Homo sapiens	Q9H074	Pull Down	11997512
Intra	PABPC1	P11940	PAIP1	Homo sapiens	Q9H074	NMR	14685257
Intra	PABPC1	P11940	PAIP1	Homo sapiens	Q9H074	Pull Down	14685257
Intra	PABPC1	P11940	PAIP1	Homo sapiens	Q9H074	FPS	37100772
Intra	PABPC1	P11940	PAIP1	Homo sapiens	Q9H074	Anti Tag CoIP	33876849
Cross	PABPC1	P11940	N	Human coronavirus 229E	P15130	X-Ray Diffraction	37100772
Cross	PABPC1	P11940	N	Human coronavirus 229E	P15130	Pull Down	37100772
Intra	PABPC1	P11940	GSPT1	Homo sapiens	P15170-2	X-Ray Diffraction	20418951
Intra	PABPC1	P11940	TNRC6B	Homo sapiens	Q9UPQ9	Pull Down	21063388
Cross	PABPC1	P11940	L	Lymphocytic choriomeningitis virus	P14240	Anti Tag CoIP	29261807
Cross	PABPC1	P11940	P/V/C	Hendra virus	O55778	FPS	37100772
Cross	PABPC1	P11940	P/V/C	Hendra virus	O55778	Pull Down	37100772

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Rift Valley Fever

Rfv - [Rift Valley Fever]

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Motor Neuron Disease

Anterior Horn Cell Disease	Motor Neuron Diseases
Mnd - [Motor Neurone Disease]	Lou Gehrig Disease
Creeping Palsy	Creeping Paralysis
Bulbar Motor Neuron Disease	Bulbar Syndrome
Anterior Horn Cell Disorder	Hereditary Motor Neuron Disease

Lymphocytic Choriomeningitis

Lcm	Lymphocytic Meningitis
Lymphocytic Choriomeningitis Virus Encephalomyelitis	Lymphocytic Meningoencephalitis
Non-Arthropod Borne Lymphocytic Choriomeningitis	Lcm - [Lymphocytic Choriomeningitis]
Benign Lymphocytic Meningitis	Meningitis Due To Lymphocytic Choriomeningitis Virus

Multisystem Proteinopathy

Waardenburg Syndrome, Type 4a

Waardenburg-Shah Syndrome	Shah-Waardenburg Syndrome
Waardenburg Syndrome Type 4a	WS4A
Ws4	Waardenburg Syndrome Type 4
Waardenburg Syndrome Type Iva	Waardenburg Syndrome With Hirschsprung Disease Type 4a
Hirschsprung Disease With Pigmentary Anomaly	Waardenburg-Hirschsprung Syndrome
Waardenburg Syndrome, Type Iva	Waardenburg Syndrome With Hirschsprung Disease, Type 4a
Waardenburg-Hirschsprung Disease	Waardenburg Syndrome, Type 4
Waardenburg Syndrome 4a

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09948	PABPC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990727	Alextatug		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PABPC1	VGNC	VGNC:81701
Canis familiaris	PABPC1	VGNC	VGNC:51778
Bos taurus	PABPC1	VGNC	VGNC:53870
Macaca mulatta	PABPC1	VGNC	VGNC:84098
Mus musculus	PABPC1	MGD	MGI:1349722
Rattus norvegicus	PABPC1	RGD	RGD:619838

Name
Email *

	Sorry, but the email address you supplied was invalid.