2. Gene
  3. PABPC1 - poly(A) binding protein cytoplasmic 1 Gene

PABPC1 - poly(A) binding protein cytoplasmic 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PAB1; PABP; PABP1; PABPC2; PABPL1

Gene ID: 26986 | Gene type: protein coding

About PABPC1

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:100,702,916-100,722,088 (from NCBI)

This gene has 40 transcripts (splice variants), 148 orthologues, 24 paralogues and is associated with 73 phenotypes. Ubiquitous expression in esophagus (RPKM 345.6), urinary bladder (RPKM 280.1) and 25 other tissues.

Summary

This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]

PABPC1 Products(1)

mRNA Protein Name
NM_002568.4 NP_002559.2 polyadenylate-binding protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA binding IDA
IDA: Inferred from direct assay
25225333 GOA
enables RNA binding IPI
IPI: Inferred from physical interaction
23041282 GOA
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
16126846 GOA
enables mRNA binding EXP
EXP: Inferred from Experiment
23041282 GOA
enables poly(A) binding IDA
IDA: Inferred from direct assay
16804161 GOA
enables poly(U) RNA binding IDA
IDA: Inferred from direct assay
21984414 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11051545 GOA
Biological Process GO Annotation Evidence Reference Source
involved in CRD-mediated mRNA stabilization IDA
IDA: Inferred from direct assay
11051545 GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
IDA: Inferred from direct assay
11051545 GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
IDA: Inferred from direct assay
18447585 GOA
involved in positive regulation of cytoplasmic translation IDA
IDA: Inferred from direct assay
11051545 GOA
involved in positive regulation of viral genome replication IMP
IMP: Inferred from mutant phenotype
26735137 GOA
Cellular Component GO Annotation Evidence Reference Source
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in cell leading edge IDA
IDA: Inferred from direct assay
28733330 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
28733330 GOA
located in cytoplasmic ribonucleoprotein granule IDA
IDA: Inferred from direct assay
15121898 GOA
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
21883093 GOA
located in cytosol IDA
IDA: Inferred from direct assay
11051545 GOA
part of mCRD-mediated mRNA stability complex IPI
IPI: Inferred from physical interaction
11051545 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21940797 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
17289661 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PABPC1 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (13 - 83)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (101 - 168)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (193 - 261)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (296 - 363)

PABP

PABP: Poly-adenylate binding protein, unique domain (543 - 614)

  • 0
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  • 200
  • 300
  • 400
  • 500
  • 600
  • 636 a.a.
Protein Preferred Names Protein Names

polyadenylate-binding protein 1

poly(A) binding protein, cytoplasmic 2

Related Diseases

Diseases Alias
Rift Valley Fever

Rfv - [Rift Valley Fever]
Dengue Virus

Dengue Virus, Susceptibility To

Dengue Fever, Protection Against

Dengue Fever
Motor Neuron Disease

Anterior Horn Cell Disease

Motor Neuron Diseases

Mnd - [Motor Neurone Disease]

Lou Gehrig Disease

Creeping Palsy

Creeping Paralysis

Bulbar Motor Neuron Disease

Bulbar Syndrome

Anterior Horn Cell Disorder

Hereditary Motor Neuron Disease
Lymphocytic Choriomeningitis

Lcm

Lymphocytic Meningitis

Lymphocytic Choriomeningitis Virus Encephalomyelitis

Lymphocytic Meningoencephalitis

Non-Arthropod Borne Lymphocytic Choriomeningitis

Lcm - [Lymphocytic Choriomeningitis]

Benign Lymphocytic Meningitis

Meningitis Due To Lymphocytic Choriomeningitis Virus
Multisystem Proteinopathy
Waardenburg Syndrome, Type 4a

Waardenburg-Shah Syndrome

Shah-Waardenburg Syndrome

Waardenburg Syndrome Type 4a

WS4A

Ws4

Waardenburg Syndrome Type 4

Waardenburg Syndrome Type Iva

Waardenburg Syndrome With Hirschsprung Disease Type 4a

Hirschsprung Disease With Pigmentary Anomaly

Waardenburg-Hirschsprung Syndrome

Waardenburg Syndrome, Type Iva

Waardenburg Syndrome With Hirschsprung Disease, Type 4a

Waardenburg-Hirschsprung Disease

Waardenburg Syndrome, Type 4

Waardenburg Syndrome 4a
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09948 PABPC1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PABPC1 VGNC VGNC:81701
Canis familiaris PABPC1 VGNC VGNC:51778
Bos taurus PABPC1 VGNC VGNC:53870
Macaca mulatta PABPC1 VGNC VGNC:84098
Mus musculus PABPC1 MGD MGI:1349722
Rattus norvegicus PABPC1 RGD RGD:619838