NOXA1 - NADPH oxidase activator 1 Gene

Homo sapiens

Also known as p51NOX; NY-CO-31; SDCCAG31

Gene ID: 10811 | Gene type: protein coding

About NOXA1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,423,393-137,434,406 (from NCBI)

This gene has 5 transcripts (splice variants), 196 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 4.2), stomach (RPKM 4.0) and 25 other tissues.

Summary

This gene encodes a protein which activates NADPH oxidases, Enzymes which catalyze a reaction generating Reactive Oxygen Species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

NOXA1 Products(3)

mRNA	Protein	Name
NM_001256067.2	NP_001242996.1	NADPH oxidase activator 1 isoform 2
NM_001256068.2	NP_001242997.1	NADPH oxidase activator 1 isoform 3
NM_006647.2	NP_006638.1	NADPH oxidase activator 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	19755710	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	16636067	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16329988	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	16636067	GOA
enables superoxide-generating NADPH oxidase activator activity	IDA IDA: Inferred from direct assay	20609497	GOA
enables superoxide-generating NADPH oxidase activator activity	IMP IMP: Inferred from mutant phenotype	16636067	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of hydrogen peroxide metabolic process	IMP IMP: Inferred from mutant phenotype	16636067	GOA
involved in regulation of respiratory burst	IMP IMP: Inferred from mutant phenotype	16636067	GOA
involved in superoxide metabolic process	IMP IMP: Inferred from mutant phenotype	20609497	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NADPH oxidase complex	IDA IDA: Inferred from direct assay	16636067	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOXA1 Protein Structure

TPR_2

PB1

SH3_1

0
100
200
300
400
483 a.a.

Protein Preferred Names

Protein Names

NADPH oxidase activator 1

NCF2-like protein

Related Diseases

Diseases

Alias

Lung Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of Lung

Granulomatous Disease, Chronic, Autosomal Recessive, 1

Chronic Granulomatous Disease Due To Deficiency Of Ncf-1	CGD1
Ncf1 Deficiency	Soluble Oxidase Component Ii Deficiency
Soc2 Deficiency	P47-Phox Deficiency
Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type I	Deficiency Of Neutrophil Cytosol Factor 1
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 1	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type I
Cgd, Autosomal Recessive Cytochrome B-Positive, Type I	Granulomatous Disease, Chronic, Due To Ncf1 Deficiency
Neutrophil Cytosol Factor 1 Deficiency	Chronic Granulomatous Disease 1, Autosomal Recessive
Autosomal Recessive Chronic Granulomatous Disease 1	Cdg1
Deficiency Of Ncf1	Deficiency Of P47-Phox
Deficiency Of Soc2	Deficiency Of Soluble Oxidase Component Ii
Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type I	Chronic Granulomatous Disease Due To Ncf1 Deficiency

Bruxism

Sleep Bruxism	Sleep-Related Bruxism
Bruxism - Teeth Grinding	Grinding Teeth
Sleep Related Bruxism	Teeth Grinding
Sleep Related Teeth Grinding

Phagocyte Bactericidal Dysfunction

Phagocytic Dysfunction

Chronic Granulomatous Disease

Cgd	Granulomatous Disease, Chronic
Autosomal Recessive Chronic Granulomatous Disease	X-Linked Chronic Granulomatous Disease
Bridges-Good Syndrome	Congenital Dysphagocytosis
Quie Syndrome	Chronic Septic Granulomatosis
Chronic Granulomatous Disorder	Granulomatous Disease Chronic
Granulomatous Disease, Chronic, X-Linked

Granulomatous Disease, Chronic, X-Linked

CGDX	Chronic Granulomatous Disease, X-Linked
X-Linked Chronic Granulomatous Disease	Cgd
Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked	Cdgx
X-Linked Chronic Cytochrome B-Negative Granulomatous Disease	Chronic Granulomatous Disease Cytochrome B-Negative X-Linked
Chronic Granulomatous Disease Cytochrome B-Positive X-Linked	Granulomatous Disease, Chronic, X-Linked, Variant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1435	NoxA1ds	Inhibitor	95.19%	Unkown
HY-P1435A	NoxA1ds TFA	Inhibitor	/	Unkown
HY-RS09465	NOXA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NOXA1	VGNC	VGNC:55664
Mus musculus	NOXA1	MGD	MGI:2449980
Rattus norvegicus	NOXA1	RGD	RGD:1306687
Bos taurus	NOXA1	VGNC	VGNC:32186
Macaca mulatta	NOXA1	VGNC	VGNC:75163
Felis catus	NOXA1	VGNC	VGNC:102956

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