2. Gene
  3. ME3 - malic enzyme 3 Gene

ME3 - malic enzyme 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NADP-ME

Gene ID: 10873 | Gene type: protein coding

About ME3

Cytogenetic location: 11q14.2 Genomic coordinates (GRCh38): 11:86,434,930-86,672,616 (from NCBI)

This gene has 12 transcripts (splice variants), 220 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 4.2), fat (RPKM 4.1) and 25 other tissues.

Summary

Malic Enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

ME3 Products(5)

mRNA Protein Name
NM_001014811.2 NP_001014811.1 NADP-dependent malic enzyme, mitochondrial isoform 1
NM_001161586.3 NP_001155058.1 NADP-dependent malic enzyme, mitochondrial isoform 1
NM_001351934.2 NP_001338863.1 NADP-dependent malic enzyme, mitochondrial isoform 1
NM_001395868.1 NP_001382797.1 NADP-dependent malic enzyme, mitochondrial isoform 2
NM_006680.3 NP_006671.2 NADP-dependent malic enzyme, mitochondrial isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables NADP+ binding IDA
IDA: Inferred from direct assay
7818469 GOA
enables malate dehydrogenase (decarboxylating) (NADP+) activity IDA
IDA: Inferred from direct assay
7818469 GOA
enables malic enzyme activity IDA
IDA: Inferred from direct assay
7818469 GOA
Biological Process GO Annotation Evidence Reference Source
involved in malate metabolic process IDA
IDA: Inferred from direct assay
7818469 GOA
involved in pyruvate metabolic process IDA
IDA: Inferred from direct assay
7818469 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ME3 Protein Structure

malic

malic: Malic enzyme, N-terminal domain (114 - 295)

Malic_M

Malic_M: Malic enzyme, NAD binding domain (305 - 557)

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  • 604 a.a.
Protein Preferred Names Protein Names

NADP-dependent malic enzyme, mitochondrial

malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))

Related Diseases

Diseases Alias
Thyroid Dyshormonogenesis 5

TDH5

Hypothyroidism, Congenital, Due To Dyshormonogenesis, 5

Thyroid Hormonogenesis, Genetic Defect In, 5

Genetic Defect In Thyroid Hormonogenesis 5

Chdh5

Congenital Hypothyroidism Due To Dyshormonogenesis Type 5

Genetic Defect In Thyroid Hormonogenesis Type 5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (53)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15648B GSK-J4 99.64% Unkown
HY-101117 EED226 Inhibitor 99.56% Unkown
HY-100421 CPI-455 Inhibitor 98.95% Unkown
HY-15648 GSK-J1 Inhibitor 99.94% Unkown
HY-120400 KDM5-C70 Inhibitor 97.08% Unkown
HY-12583 A-366 Inhibitor 98.01% Unkown
HY-15648F GSK-J4 hydrochloride Inhibitor 99.01% Unkown
HY-150190 F5446 99.38% Unkown
HY-100014 KDM5A-IN-1 Inhibitor 99.80% Unkown
HY-16705 BRD4770 Inhibitor 99.69% Unkown
HY-119344 MS37452 Inhibitor 99.81% Unkown
HY-N7404 Nε,Nε,Nε-Trimethyllysine chloride 99.14% Unkown
HY-125837A MS31 trihydrochloride Inhibitor ≥98.0% Unkown
HY-125292 NV03 Antagonist 98.82% Unkown
HY-100764 YUKA1 Inhibitor 99.56% Unkown
HY-15648A GSK-J2 Control 99.76% Unkown
HY-150249 GSK3735967 Inhibitor 99.71% Unkown
HY-N7404S Nε,Nε,Nε-Trimethyllysine-d9 chloride ≥95.0% Unkown
HY-138691A JQKD82 trihydrochloride Inhibitor 99.94% Unkown
HY-148458 EZH2-IN-14 Inhibitor 99.02% Unkown
HY-157164 PROTAC EZH2 Degrader-2 Degrader 99.78% Unkown
HY-153191 EZH2-IN-15 Inhibitor 99.68% Unkown
HY-153368 Zomiradomide Degrader 95.43% Unkown
HY-W051391 1,4,7-Trimethyl-1,4,7-triazonane 98.50% Unkown
HY-P2257 H3K4(Me3) (1-20) 98.69% Unkown
HY-126327 UNC4976 Antagonist / Unkown
HY-158432 GT-653 Degrader / Unkown
HY-66026 Fmoc-Lys(Me)3-OH Chloride / Unkown
HY-125837 MS31 Inhibitor / Unkown
HY-126327A UNC4976 TFA Antagonist ≥98.0% Unkown
HY-P2255 H3K4(Me) (1-20) 99.82% Unkown
HY-100421A CPI-455 hydrochloride Inhibitor / Unkown
HY-122595 EZH2-IN-1 Inhibitor / Unkown
HY-138691 JQKD82 Inhibitor / Unkown
HY-143616 EZH2-IN-7 Inhibitor / Unkown
HY-150619 KDM4-IN-4 Inhibitor / Unkown
HY-154599 5-Me-3’-dU-2’-phosphoramidite / Unkown
HY-156292 IHMT-EZH2-426 Inhibitor / Unkown
HY-15648G GSK-J1 sodium Inhibitor / Unkown
HY-15648I GSK-J2 sodium Inhibitor / Unkown
HY-162601 D-01 Inhibitor / Unkown
HY-168131 PROTAC EZH2 Degrader-3 / Unkown
HY-169375 RSL3-4-Me Control / Unkown
HY-P10111A Histone H3K9me3 (1-15) TFA / Unkown
HY-P2252 H3K27(Me) (15-34) / Unkown
HY-P2253 H3K27(Me2) (15-34) / Unkown
HY-RS08272 ME3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W100209 5Me3F4AP Inhibitor 97.65% Unkown
HY-106258 Atilmotin Agonist / Unkown
HY-138691B JQKD82 dihydrochloride Inhibitor / Unkown
HY-15648D GSK-J1 lithium salt Inhibitor 98.26% Unkown
HY-169919 HDM-IN-1 Inhibitor / Unkown
HY-P10463 ssK36 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ME3 MGD MGI:1916679
Felis catus ME3 VGNC VGNC:68227
Macaca mulatta ME3 VGNC VGNC:74695
Rattus norvegicus ME3 RGD RGD:1311070
Bos taurus ME3 VGNC VGNC:31341
Canis familiaris ME3 VGNC VGNC:43111
Others ME3 NCBI