2. Epigenetics
  3. Histone Demethylase
  4. YUKA1

YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM, less active on KDM5C (IC50, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity.

For research use only. We do not sell to patients.

YUKA1 Chemical Structure

YUKA1 Chemical Structure

CAS No. : 708991-09-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 374 In-stock
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5 mg USD 340 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

YUKA1 Related Antibodies

Top Publications Citing Use of Products

View All Histone Demethylase Isoform Specific Products:

View All Isoforms
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM, less active on KDM5C (IC50, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity[1].

IC50 & Target

KDM5

 

Molecular Weight

292.36

Formula

C13H16N4O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C=CCOC1=C(CNN2C(NN=C2)=S)C=CC=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (342.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4204 mL 17.1022 mL 34.2044 mL
5 mM 0.6841 mL 3.4204 mL 6.8409 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4204 mL 17.1022 mL 34.2044 mL 85.5110 mL
5 mM 0.6841 mL 3.4204 mL 6.8409 mL 17.1022 mL
10 mM 0.3420 mL 1.7102 mL 3.4204 mL 8.5511 mL
15 mM 0.2280 mL 1.1401 mL 2.2803 mL 5.7007 mL
20 mM 0.1710 mL 0.8551 mL 1.7102 mL 4.2756 mL
25 mM 0.1368 mL 0.6841 mL 1.3682 mL 3.4204 mL
30 mM 0.1140 mL 0.5701 mL 1.1401 mL 2.8504 mL
40 mM 0.0855 mL 0.4276 mL 0.8551 mL 2.1378 mL
50 mM 0.0684 mL 0.3420 mL 0.6841 mL 1.7102 mL
60 mM 0.0570 mL 0.2850 mL 0.5701 mL 1.4252 mL
80 mM 0.0428 mL 0.2138 mL 0.4276 mL 1.0689 mL
100 mM 0.0342 mL 0.1710 mL 0.3420 mL 0.8551 mL
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YUKA1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YUKA1708991-09-7YUKA 1YUKA-1Histone DemethylaseInhibitorinhibitorinhibit

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