RAB10 - RAB10, member RAS oncogene family Gene

Homo sapiens

Gene ID: 10890 | Gene type: protein coding

About RAB10

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,033,285-26,137,454 (from NCBI)

This gene has 4 transcripts (splice variants), 215 orthologues and 68 paralogues. Ubiquitous expression in esophagus (RPKM 102.3), colon (RPKM 40.9) and 25 other tissues.

Summary

RAB10 belongs to the Ras (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]

RAB10 Products(1)

mRNA	Protein	Name
NM_016131.5	NP_057215.3	ras-related protein Rab-10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	20937701	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	20937701	GOA
enables myosin V binding	IPI IPI: Inferred from physical interaction	22908308	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	19717423	GOA
involved in endoplasmic reticulum tubular network organization	IMP IMP: Inferred from mutant phenotype	23263280	GOA
involved in endosomal transport	IMP IMP: Inferred from mutant phenotype	16641372	GOA
involved in establishment of protein localization to endoplasmic reticulum membrane	IMP IMP: Inferred from mutant phenotype	23263280	GOA
involved in establishment of protein localization to membrane	IMP IMP: Inferred from mutant phenotype	24006491	GOA
involved in regulated exocytosis	IMP IMP: Inferred from mutant phenotype	2732579	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	23263280	GOA
located in cilium	IDA IDA: Inferred from direct assay	20576682	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	23263280	GOA
located in endoplasmic reticulum tubular network	IDA IDA: Inferred from direct assay	23263280	GOA
located in endosome	IDA IDA: Inferred from direct assay	20576682	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	32344433	GOA
located in exocytic vesicle	IDA IDA: Inferred from direct assay	18504258	GOA
located in insulin-responsive compartment	IDA IDA: Inferred from direct assay	22908308	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	22908308	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	16641372	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB10 Protein Structure

Ras

0
100
200 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-10

GTP-binding protein RAB10

RAB10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB10	P61026	RAB39A	Homo sapiens	Q14964	Crosslink	30021884
Intra	RAB10	P61026	RAB39A	Homo sapiens	Q14964	Anti Tag CoIP	26824392
Intra	RAB10	P61026	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	26824392
Intra	RAB10	P61026	RILPL2	Homo sapiens	Q969X0	Anti Tag CoIP	32017888
Intra	RAB10	P61026	OPTN	Homo sapiens	Q96CV9	Y2H Prey Pooling	25416956
Intra	RAB10	P61026	OPTN	Homo sapiens	Q96CV9	Y2H Array	25416956
Intra	RAB10	P61026	OPTN	Homo sapiens	Q96CV9	Validated Y2H	25416956
Intra	RAB10	P61026	PPM1H	Homo sapiens	Q9ULR3	Anti Tag CoIP	31663853

Cross: Cross-species interaction Intra: Intraspecies interaction

RAB10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82044	Rab10 Antibody (YA1789)	WB, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Carpenter Syndrome 1

Carpenter Syndrome	Acrocephalopolysyndactyly Type Ii
Acps Ii	CRPT1
Acrocephalopolysyndactyly Type 2	Acrocephalosyndactyly, Type Ii
Acrocephalopolysyndactyly 2	Acps2
Acps 2	Type Ii Acrocephalosyndactyly
Carpenter Syndrome, Type 1	Apert-Crouzon Disease

Microvillus Inclusion Disease

Congenital Microvillous Atrophy	Intractable Diarrhea Of Infancy
Congenital Familial Protracted Diarrhea With Enterocyte Brush-Border Abnormalities	Davidson Disease
Microvillous Inclusion Disease	Congenital Microvillus Atrophy
Mvid	Diarrhea 2 With Microvillus Atrophy
Mvd	Congenital Familial Protracted Diarrhea
Davidson'S Disease	Familial Enteropathy, Microvillus
Microvillus Atrophy, Congenital	Congenital Enteropathy
Familial Protracted Enteropathy	Microvillous Atrophy
Microvillus Atrophy With Diarrhea 2	Idi

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Warburg Micro Syndrome 1

Warburg Micro Syndrome	Micro Syndrome
Warbm	WARBM1
Warburg Sjo Fledelius Syndrome	Warburg-Sjo-Fledelius Syndrome
Micro Syndrome 1	Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11514	RAB10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAB10	VGNC	VGNC:106202
Rattus norvegicus	RAB10	RGD	RGD:620879
Canis familiaris	RAB10	VGNC	VGNC:45247
Felis catus	RAB10	VGNC	VGNC:81163
Mus musculus	RAB10	MGD	MGI:105066
Bos taurus	RAB10	VGNC	VGNC:33613
Others	RAB10	NCBI

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