RAB39A - RAB39A, member RAS oncogene family Gene

Homo sapiens

Also known as K28; RAB39

Gene ID: 54734 | Gene type: protein coding

About RAB39A

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:107,928,448-107,963,482 (from NCBI)

This gene has 1 transcript (splice variant), 208 orthologues and 68 paralogues. Broad expression in brain (RPKM 2.3), appendix (RPKM 1.8) and 16 other tissues.

Summary

Predicted to enable GTPase activity. Involved in phagosome acidification and phagosome-lysosome fusion. Located in phagocytic vesicle. [provided by Alliance of Genome Resources, Apr 2022]

RAB39A Products(1)

mRNA	Protein	Name
NM_017516.3	NP_059986.1	ras-related protein Rab-39A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24349490	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in phagosome acidification	IMP IMP: Inferred from mutant phenotype	21255211	GOA
involved in phagosome-lysosome fusion	IMP IMP: Inferred from mutant phenotype	21255211	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	21255211	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB39A Protein Structure

Ras

0
100
200
217 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-39A

RAB39, member RAS oncogene family

RAB39A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB39A	Q14964	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	RAB39A	Q14964	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	25416956
Intra	RAB39A	Q14964	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	32296183
Intra	RAB39A	Q14964	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	25416956
Intra	RAB39A	Q14964	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	RAB39A	Q14964	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	25416956
Intra	RAB39A	Q14964	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	RAB39A	Q14964	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	RAB39A	Q14964	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	RAB39A	Q14964	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	RAB39A	Q14964	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	RAB39A	Q14964	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	RAB39A	Q14964	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	RAB39A	Q14964	BECN1	Homo sapiens	Q14457	Anti Tag CoIP	24349490

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Waisman Syndrome

Early-Onset Parkinsonism-Intellectual Disability Syndrome	Bgmr
Wsn	Laxova-Opitz Syndrome
WSMN	Parkinsonism, Early-Onset, With Mental Retardation
Basal Ganglion Disorder With Mental Retardation	Basal Ganglia Disorder With Intellectual Disability
Laxova Brown Hogan Syndrome	X-Linked Recessive Basal Ganglia Disorder With Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11553	RAB39A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RAB39A	VGNC	VGNC:104319
Bos taurus	RAB39A	VGNC	VGNC:33647
Mus musculus	RAB39A	MGD	MGI:2442855
Macaca mulatta	RAB39A	VGNC	VGNC:81537
Rattus norvegicus	RAB39A	RGD	RGD:1311286

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