PPM1H - protein phosphatase, Mg2+/Mn2+ dependent 1H Gene

Homo sapiens

Also known as URCC2; ARHCL1; NERPP-2C

Gene ID: 57460 | Gene type: protein coding

About PPM1H

Cytogenetic location: 12q14.1-q14.2 Genomic coordinates (GRCh38): 12:62,643,994-62,935,150 (from NCBI)

This gene has 5 transcripts (splice variants), 282 orthologues and 16 paralogues. Broad expression in brain (RPKM 7.7), prostate (RPKM 6.7) and 23 other tissues.

Summary

Enables identical protein binding activity and phosphoprotein Phosphatase activity. Predicted to be involved in protein dephosphorylation. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PPM1H Products(1)

mRNA	Protein	Name
NM_020700.2	NP_065751.1	protein phosphatase 1H

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables phosphoprotein phosphatase activity	IMP IMP: Inferred from mutant phenotype	22586611	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	31663853	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22586611	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22586611	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPM1H Protein Structure

PP2C

0
100
200
300
400
514 a.a.

Protein Preferred Names

Protein Names

protein phosphatase 1H

neurite extension-related protein phosphatase related to PP2C

PPM1H Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPM1H	Q9ULR3	RAB10	Homo sapiens	P61026	Phosphatase Assay	31663853
Intra	PPM1H	Q9ULR3	RAB10	Homo sapiens	P61026	Anti Tag CoIP	31663853
Intra	PPM1H	Q9ULR3	RAB10	Homo sapiens	P61026	Confocal	31663853
Intra	PPM1H	Q9ULR3	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	27880917
Intra	PPM1H	Q9ULR3	PPM1H	Homo sapiens	Q9ULR3	Validated Y2H	32296183
Intra	PPM1H	Q9ULR3	PPM1H	Homo sapiens	Q9ULR3	Y2H Array	32296183
Intra	PPM1H	Q9ULR3	PPM1J	Homo sapiens	Q5JR12	Anti Tag CoIP	27880917
Intra	PPM1H	Q9ULR3	PPM1J	Homo sapiens	Q5JR12	Anti Tag CoIP	31663853
Intra	PPM1H	Q9ULR3	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	27880917
Intra	PPM1H	Q9ULR3	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	27880917
Intra	PPM1H	Q9ULR3	PPM1H	Homo sapiens	Q9ULR3	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Multiple Endocrine Neoplasia, Type Iv

Multiple Endocrine Neoplasia Type 4	MEN4
Multiple Endocrine Neoplasia 4	Neoplasia, Endocrine, Multiple, Type Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10966	PPM1H Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPM1H	RGD	RGD:1309528
Macaca mulatta	PPM1H	VGNC	VGNC:76060
Canis familiaris	PPM1H	VGNC	VGNC:44868
Mus musculus	PPM1H	MGD	MGI:2442087
Felis catus	PPM1H	VGNC	VGNC:64312
Bos taurus	PPM1H	VGNC	VGNC:33214
Others	PPM1H	NCBI

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