2. Gene
  3. TCERG1 - transcription elongation regulator 1 Gene

TCERG1 - transcription elongation regulator 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Urn1; CA150; TAF2S

Gene ID: 10915 | Gene type: protein coding

About TCERG1

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:146,447,330-146,511,961 (from NCBI)

This gene has 17 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 13.0) and 25 other tissues.

Summary

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]

TCERG1 Products(16)

mRNA Protein Name
NM_001040006.2 NP_001035095.1 transcription elongation regulator 1 isoform 2
NM_001382548.1 NP_001369477.1 transcription elongation regulator 1 isoform 3
NM_001400077.1 NP_001387006.1 transcription elongation regulator 1 isoform 4
NM_001400082.1 NP_001387011.1 transcription elongation regulator 1 isoform 5
NM_001400083.1 NP_001387012.1 transcription elongation regulator 1 isoform 6
NM_001400084.1 NP_001387013.1 transcription elongation regulator 1 isoform 7
NM_001400085.1 NP_001387014.1 transcription elongation regulator 1 isoform 8
NM_001400092.1 NP_001387021.1 transcription elongation regulator 1 isoform 9
NM_001400093.1 NP_001387022.1 transcription elongation regulator 1 isoform 10
NM_001400094.1 NP_001387023.1 transcription elongation regulator 1 isoform 11
NM_001400095.1 NP_001387024.1 transcription elongation regulator 1 isoform 16
NM_001400096.1 NP_001387025.1 transcription elongation regulator 1 isoform 12
NM_001400097.1 NP_001387026.1 transcription elongation regulator 1 isoform 13
NM_001400098.1 NP_001387027.1 transcription elongation regulator 1 isoform 14
NM_001400099.1 NP_001387028.1 transcription elongation regulator 1 isoform 15
NM_006706.4 NP_006697.2 transcription elongation regulator 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
20956529 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
17060612 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15383276 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
20956529 GOA
enables ubiquitin-like protein conjugating enzyme binding IPI
IPI: Inferred from physical interaction
20215116 GOA
Biological Process GO Annotation Evidence Reference Source
involved in RNA splicing IDA
IDA: Inferred from direct assay
20215116 GOA
involved in mRNA processing IDA
IDA: Inferred from direct assay
20215116 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20956529 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20215116 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCERG1 Protein Structure

WW

WW: WW domain (137 - 162)

WW

WW: WW domain (434 - 460)

FF

FF: FF domain (663 - 709)

FF

FF: FF domain (727 - 776)

FF

FF: FF domain (794 - 843)

FF

FF: FF domain (898 - 949)

FF

FF: FF domain (956 - 1007)

FF

FF: FF domain (1015 - 1074)

  • 0
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  • 1000
  • 1098 a.a.
Protein Preferred Names Protein Names

transcription elongation regulator 1

TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD

Related Diseases

Diseases Alias
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Human Immunodeficiency Virus Type 1

Aids

Hiv/Aids

Aids, Delayed/Rapid Progression To

Hiv-1, Susceptibility To

Hiv-1 Viremia, Susceptibility To

Human Immunodeficiency Virus Type 1, Susceptibility To

Hiv-1

Aids, Slow Progression To

Rapid Progression To Aids From Hiv1 Infection

Hiv1 Infection, Resistance To

Hiv1 Infection

Hiv-1 Viremia

Aids, Resistance To

Aids, Rapid Progression To

Hiv/Aids, Susceptibility To

Hiv-1, Resistance To

Hiv1, Resistance To

Hiv1

Hiv-1 Disease, Delayed Progression Of

Hiv-1 Disease, Rapid Progression Of

Hiv Infection, Resistance To

Hiv Type 1, Susceptibility To

Hiv Type 1

Hiv-1 Infection

Human Immunodeficiency Virus I Infection

Acquired Immunodeficiency Syndrome

Hiv-Infection/Aids
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14297 TCERG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14298 TCERG1L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TCERG1 VGNC VGNC:47188
Rattus norvegicus TCERG1 RGD RGD:1311748
Macaca mulatta TCERG1 VGNC VGNC:78389
Bos taurus TCERG1 VGNC VGNC:35685
Felis catus TCERG1 VGNC VGNC:66020
Mus musculus TCERG1 MGD MGI:1926421