2. Gene
  3. FASTK - Fas activated serine/threonine kinase Gene

FASTK - Fas activated serine/threonine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as FAST

Gene ID: 10922 | Gene type: protein coding

About FASTK

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:151,076,624-151,080,809 (from NCBI)

This gene has 16 transcripts (splice variants), 191 orthologues and 5 paralogues. Ubiquitous expression in duodenum (RPKM 16.4), prostate (RPKM 16.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated Apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte Apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]

FASTK Products(3)

mRNA Protein Name
NM_001258461.2 NP_001245390.1 fas-activated serine/threonine kinase isoform 5
NM_006712.5 NP_006703.1 fas-activated serine/threonine kinase isoform 1
NM_033015.4 NP_148936.2 fas-activated serine/threonine kinase isoform 4

FASTK Protein Structure

FAST_1

FAST_1: FAST kinase-like protein, subdomain 1 (277 - 343)

FAST_2

FAST_2: FAST kinase-like protein, subdomain 2 (354 - 444)

RAP

RAP: RAP domain (484 - 536)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 549 a.a.
Protein Preferred Names Protein Names

fas-activated serine/threonine kinase

FAST kinase

FASTK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FASTK Q14296 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra
FASTK Q14296 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra
FASTK Q14296 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra
FASTK Q14296 CHERP Homo sapiens Q8IWX8
Validated Y2H
32296183
Intra
FASTK Q14296 WIPF1 Homo sapiens O43516
Validated Y2H
25416956
Intra
FASTK Q14296 WIPF1 Homo sapiens O43516
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04756 FASTK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FASTK MGD MGI:1913837
Bos taurus FASTK VGNC VGNC:28872
Macaca mulatta FASTK VGNC VGNC:72565
Canis familiaris FASTK VGNC VGNC:40737
Rattus norvegicus FASTK RGD RGD:1311601
Felis catus FASTK VGNC VGNC:62153