2. Gene
  3. CHERP - calcium homeostasis endoplasmic reticulum protein Gene

CHERP - calcium homeostasis endoplasmic reticulum protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SRA1; DAN16; SCAF6

Gene ID: 10523 | Gene type: protein coding

About CHERP

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,517,894-16,542,437 (from NCBI)

This gene has 7 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in testis (RPKM 13.3), spleen (RPKM 10.7) and 25 other tissues.

Summary

Enables transmembrane transporter binding activity. Involved in positive regulation of calcineurin-NFAT signaling cascade and release of sequestered calcium ion into cytosol. Acts upstream of or within cellular calcium ion homeostasis and negative regulation of cell population proliferation. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CHERP Products(1)

mRNA Protein Name
NM_006387.6 NP_006378.3 calcium homeostasis endoplasmic reticulum protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22365833 GOA
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
21454501 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
10794731 GOA
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10794731 GOA
involved in positive regulation of calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
12656674 GOA
involved in release of sequestered calcium ion into cytosol IMP
IMP: Inferred from mutant phenotype
12656674 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10794731 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12656674 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHERP Protein Structure

Surp

Surp: Surp module (13 - 61)

CTD_bind

CTD_bind: RNA polymerase II-binding domain. (211 - 274)

G-patch

G-patch: G-patch domain (842 - 888)

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  • 916 a.a.
Protein Preferred Names Protein Names

calcium homeostasis endoplasmic reticulum protein

ERPROT 213-21

CHERP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CHERP Q8IWX8 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
CHERP Q8IWX8 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
CHERP Q8IWX8 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
Intra
CHERP Q8IWX8 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
Intra
CHERP Q8IWX8 RBFOX2 Homo sapiens O43251-10
Y2H Array
32296183
Intra
CHERP Q8IWX8 RBFOX2 Homo sapiens O43251-10
Y2H Prey Pooling
32296183
Intra
CHERP Q8IWX8 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra
CHERP Q8IWX8 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra
CHERP Q8IWX8 TLE3 Homo sapiens Q04726-4
Y2H Prey Pooling
32296183
Intra
CHERP Q8IWX8 TLE3 Homo sapiens Q04726-4
Y2H Array
32296183
Intra
CHERP Q8IWX8 FIGN Homo sapiens Q5HY92
Y2H Prey Pooling
32296183
Intra
CHERP Q8IWX8 FIGN Homo sapiens Q5HY92
Y2H Array
32296183
Intra
CHERP Q8IWX8 FASTK Homo sapiens Q14296
Y2H Array
32296183
Intra
CHERP Q8IWX8 FASTK Homo sapiens Q14296
Y2H Prey Pooling
32296183
Intra
CHERP Q8IWX8 DHX8 Homo sapiens Q14562
Y2H
22365833
Intra
CHERP Q8IWX8 SNRNP27 Homo sapiens Q8WVK2
Y2H
22365833
Intra
CHERP Q8IWX8 SAXO1 Homo sapiens Q8IYX7
Y2H Array
32296183
Intra
CHERP Q8IWX8 SAXO1 Homo sapiens Q8IYX7
Y2H Prey Pooling
32296183
Intra
CHERP Q8IWX8 SAXO1 Homo sapiens Q8IYX7
Validated Y2H
32296183
Intra
CHERP Q8IWX8 LUC7L Homo sapiens Q9NQ29
Anti Tag CoIP
22365833
Intra
CHERP Q8IWX8 LUC7L Homo sapiens Q9NQ29
Y2H
22365833
Intra
CHERP Q8IWX8 FRA10AC1 Homo sapiens Q70Z53
Anti Tag CoIP
22365833
Intra
CHERP Q8IWX8 FRA10AC1 Homo sapiens Q70Z53
Y2H
22365833
Intra
CHERP Q8IWX8 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra
CHERP Q8IWX8 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra
CHERP Q8IWX8 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra
CHERP Q8IWX8 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
CHERP Q8IWX8 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
CHERP Q8IWX8 U2AF2 Homo sapiens P26368
Anti Tag CoIP
22365833
Intra
CHERP Q8IWX8 SF1 Homo sapiens Q15637
Pull Down
26420826
Intra
CHERP Q8IWX8 CLK3 Homo sapiens P49761
Y2H Prey Pooling
32296183
Intra
CHERP Q8IWX8 CLK3 Homo sapiens P49761
Validated Y2H
32296183
Intra
CHERP Q8IWX8 CLK3 Homo sapiens P49761
Y2H Array
32296183
Intra
CHERP Q8IWX8 LASP1 Homo sapiens Q14847-2
Y2H Array
32296183
Intra
CHERP Q8IWX8 LASP1 Homo sapiens Q14847-2
Y2H Prey Pooling
32296183
Intra
CHERP Q8IWX8 C1orf94 Homo sapiens Q6P1W5
Y2H Array
32296183
Intra
CHERP Q8IWX8 C1orf94 Homo sapiens Q6P1W5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 7

Spinocerebellar Ataxia Type 7

SCA7

Opca3

Opca Iii

Olivopontocerebellar Atrophy Iii

Opca With Retinal Degeneration

Opca With Macular Degeneration And External Ophthalmoplegia

Adca, Type Ii

Autosomal Dominant Cerebellar Ataxia Type 2

Olivopontocerebellar Atrophy 3

Autosomal Dominant Cerebellar Ataxia, Type Ii

Autosomal Dominant Cerebellar Ataxia Type Ii

Adca2

Adcaii

Ataxia With Pigmentary Retinopathy

Cerebellar Syndrome-Pigmentary Maculopathy Syndrome

Olivopontocerebellar Atrophy With Retinal Degeneration

Spinocerebellar Ataxia-7

Ataxia, Spinocerebellar, Type 7
Primary Cerebellar Degeneration

Spinocerebellar Degenerations

Cerebellar Degenerations, Primary

Spinocerebellar Degeneration
Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1

SCA1

Olivopontocerebellar Atrophy I

Opca1

Opca4

Menzel Type Opca

Schut-Haymaker Type Opca

Spinocerebellar Atrophy I

Opca I

Olivopontocerebellar Atrophy Iv

Opca Iv

Cerebelloparenchymal Disorder I

Cpd1

Olivopontocerebellar Atrophy 1

Cerebelloparenchymal Disorder 1

Olivopontocerebellar Atrophy 4

Spinocerebellar Atrophy 1

Type 1 Spinocerebellar Ataxia

Spinocerebellar Ataxia-1

Ataxia, Spinocerebellar, Type 1
Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Oculopharyngeal Muscular Dystrophy

OPMD

Muscular Dystrophy, Oculopharyngeal

Dystrophy, Oculopharyngeal Muscular

Oculopharyngeal Dystrophy

Progressive Muscular Dystrophy, Oculopharyngeal Type

Muscular Dystrophy Oculopharyngeal

Dystrophy, Muscular, Oculopharyngeal
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar
Pancreatic Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Pancreas

Adenosquamous Carcinoma Of The Pancreas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02622 CHERP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CHERP VGNC VGNC:39210
Bos taurus CHERP VGNC VGNC:27287
Rattus norvegicus CHERP RGD RGD:1305279
Felis catus CHERP VGNC VGNC:60852
Mus musculus CHERP MGD MGI:106417
Macaca mulatta CHERP VGNC VGNC:70960