WIPF1 - WAS/WASL interacting protein family member 1 Gene

Homo sapiens

Also known as WIP; WAS2; PRPL-2; WASPIP

Gene ID: 7456 | Gene type: protein coding

About WIPF1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:174,559,574-174,682,913 (from NCBI)

This gene has 26 transcripts (splice variants), 169 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 61.9), appendix (RPKM 50.1) and 23 other tissues.

Summary

This gene encodes a protein that plays an important role in the organization of the actin Cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

WIPF1 Products(10)

mRNA	Protein	Name
NM_001077269.1	NP_001070737.1	WAS/WASL-interacting protein family member 1 isoform a
NM_001375832.1	NP_001362761.1	WAS/WASL-interacting protein family member 1 isoform a
NM_001375833.1	NP_001362762.1	WAS/WASL-interacting protein family member 1 isoform a
NM_001375834.1	NP_001362763.1	WAS/WASL-interacting protein family member 1 isoform a
NM_001375835.1	NP_001362764.1	WAS/WASL-interacting protein family member 1 isoform b
NM_001375836.1	NP_001362765.1	WAS/WASL-interacting protein family member 1 isoform c
NM_001375837.1	NP_001362766.1	WAS/WASL-interacting protein family member 1 isoform c
NM_001375838.1	NP_001362767.1	WAS/WASL-interacting protein family member 1 isoform c
NM_001375839.1	NP_001362768.1	WAS/WASL-interacting protein family member 1 isoform d
NM_003387.5	NP_003378.3	WAS/WASL-interacting protein family member 1 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	19798448	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9405671	GOA
enables protein folding chaperone	EXP EXP: Inferred from Experiment	23870269	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WIPF1 Protein Structure

WH2

0
100
200
300
400
503 a.a.

Protein Preferred Names

Protein Names

WAS/WASL-interacting protein family member 1

WASP-interacting protein

WIPF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WIPF1	O43516	FASTK	Homo sapiens	Q14296	Y2H Prey Pooling	25416956
Intra	WIPF1	O43516	HCK	Homo sapiens	P08631	Pull Down	12029088
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	Validated Y2H	25416956
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	Y2H	16488394
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	Y2H Array	25416956
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	Y2H	9405671
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	Pull Down	16488394
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	IF	19817875
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	Y2H Array	21988832
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	Pull Down	9405671
Intra	WIPF1	O43516	WAS	Homo sapiens	P42768	Anti Bait CoIP	17213309
Intra	WIPF1	O43516	NCK1	Homo sapiens	P16333	Pull Down	12620186
Intra	WIPF1	O43516	ALAS1	Homo sapiens	P13196	Y2H Array	25416956
Cross	WIPF1	O43516	Cttn	Mus musculus	Q60598	Pull Down	12620186
Intra	WIPF1	O43516	GRB2	Homo sapiens	P62993	Y2H Array	21988832
Intra	WIPF1	O43516	ABI2	Homo sapiens	Q9NYB9	Y2H Array	29892012
Intra	WIPF1	O43516	ABI2	Homo sapiens	Q9NYB9	Validated Y2H	25416956
Intra	WIPF1	O43516	ABI2	Homo sapiens	Q9NYB9	Y2H Array	25416956
Intra	WIPF1	O43516	WWP2	Homo sapiens	O00308	Y2H Array	25416956
Intra	WIPF1	O43516	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	25416956
Intra	WIPF1	O43516	SEC24C	Homo sapiens	P53992	Y2H Prey Pooling	25416956
Intra	WIPF1	O43516	SEC24C	Homo sapiens	P53992	Validated Y2H	25416956
Intra	WIPF1	O43516	SEC24C	Homo sapiens	P53992	Y2H Array	25416956
Intra	WIPF1	O43516	WASL	Homo sapiens	O00401	Y2H Prey Pooling	25416956
Intra	WIPF1	O43516	WASL	Homo sapiens	O00401	Y2H	11331876
Intra	WIPF1	O43516	WASL	Homo sapiens	O00401	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Wiskott-Aldrich Syndrome 2

WAS2	Wipf1 Deficiency
Wip Deficiency

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia	XLN
SCNX	Severe Congenital Neutropenia X-Linked
Neutropenia, Congenital, Severe, X-Linked

Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia

Platelet Abnormalities With Eosinophilia And Immune-Mediated Inflammatory Disease	IMD71
Plteid	Immunodeficiency 71

Pedophilia

Paedophilia

Ceroid Lipofuscinosis, Neuronal, 6a

Neuronal Ceroid Lipofuscinosis 6	CLN6
Vlincl	Cln6 Disease
Ceroid Lipofuscinosis, Neuronal, 6	Late-Infantile Neuronal Ceroid Lipofuscinosis
CLN6A	Neuronal Ceroid Lipofuscinosis, Late Infantile, Variant
Neuronal Ceroid Lipofuscinosis 6a	Neuronal Ceroid Lipofuscinosis 6 Variable Age Of Onset
Cln6 Disease, Adult Kufs Type A	Cln6 Disease, Late Infantile
Neuronal Ceroid Lipofuscinosis, Gypsy/Indian Early Juvenile Variant	Ceroid Lipofuscinosis Neuronal 6
Cln6-Related Neuronal Ceroid Lipofuscinosis	Late Infantile Neuronal Ceroid Lipofuscinosis
Jansky-Bielschowsky Disease	Lincl
Late Infantile Ncl	Neuronal Ceroid Lipofuscinosis 6 With Variable Age At Onset
Variant Late-Onset Infantile Neuronal Ceroid Lipofuscinosis	Ceroid Lipofuscinosis, Neuronal, Late Infantile, Variant
Lipofuscinosis, Ceroid, Neuronal, Type 6	Ceroid Lipofuscinosis, Neuronal, 5

Subendocardial Myocardial Infarction

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Omenn Syndrome

Histiocytic Medullary Reticulosis	Severe Combined Immunodeficiency With Hypereosinophilia
Combined Immunodeficiency With Hypereosinophilia	Reticuloendotheliosis, Familial, With Eosinophilia
Reticuloendotheliosis Familial With Eosinophilia	Familial Reticuloendotheliosis
Omenn'S Syndrome	OS
Malignant Histiocytosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15817	WIPF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	WIPF1	VGNC	VGNC:67073
Macaca mulatta	WIPF1	VGNC	VGNC:78784
Canis familiaris	WIPF1	VGNC	VGNC:48410
Bos taurus	WIPF1	VGNC	VGNC:36939
Rattus norvegicus	WIPF1	RGD	RGD:620887
Mus musculus	WIPF1	MGD	MGI:2178801

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