PRDX3 - peroxiredoxin 3 Gene

Homo sapiens

Also known as AOP1; MER5; AOP-1; PPPCD; SP-22; HBC189; SCAR32; PRO1748; prx-III

Gene ID: 10935 | Gene type: protein coding

About PRDX3

Cytogenetic location: 10q26.11 Genomic coordinates (GRCh38): 10:119,167,720-119,178,812 (from NCBI)

This gene has 3 transcripts (splice variants), 227 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 195.5), kidney (RPKM 144.1) and 25 other tissues.

Summary

This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue Bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate Cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]

PRDX3 Products(2)

mRNA	Protein	Name
NM_001302272.2	NP_001289201.1	thioredoxin-dependent peroxide reductase, mitochondrial isoform c precursor
NM_006793.5	NP_006784.1	thioredoxin-dependent peroxide reductase, mitochondrial isoform a precursor

PRDX3 Protein Structure

AhpC-TSA

1-cysPrx_C

0
100
200
256 a.a.

Protein Preferred Names

Protein Names

thioredoxin-dependent peroxide reductase, mitochondrial

antioxidant protein 1

Recombinant PRDX3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71147	PRDX3 Protein, Human	P30048-1 (P63-Q256)	≥95%

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia, Autosomal Recessive 32

SCAR32

Spinocerebellar Ataxia, Autosomal Recessive, 32

Corneal Dystrophy, Punctiform And Polychromatic Pre-Descemet

PPPCD

Autosomal Recessive Cerebellar Ataxia

Arca

Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy	Fuchs Endothelial Dystrophy
Fuchs Dystrophy	Fced
Fuchs' Corneal Dystrophy	Fuchs' Endothelial Corneal Dystrophy
Fuchs Atrophy	Fuchs Corneal Dystrophy
Endoepithelial Corneal Dystrophy	Fecd
Late Hereditary Endothelial Dystrophy	Corneal Dystrophy, Fuchs Endothelial
Dystrophy, Corneal, Fuchs Endothelial	Corneal Dystrophy, Fuchs' Endothelial, 1

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Ocular Cancer

Eye Neoplasm	Eye Carcinoma
Eye Cancer	Eye Neoplasms
Malignant Eye Neoplasm	Neoplasm Of Eye
Neoplasm Of Eye Proper	Ocular Tumor
Carcinoma Of Eye	Ocular Carcinoma
Malignant Tumor Of Eye

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10132	PRDX3(103-112), human		/	Unkown
HY-P10133	PRDX3(103-112) SO3 modified, human		/	Unkown
HY-RS11076	PRDX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRDX3	MGD	MGI:88034
Felis catus	PRDX3	VGNC	VGNC:69038
Bos taurus	PRDX3	VGNC	VGNC:33301
Macaca mulatta	PRDX3	VGNC	VGNC:76394
Rattus norvegicus	PRDX3	RGD	RGD:620040
Others	PRDX3	NCBI

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