TMED2 - transmembrane p24 trafficking protein 2 Gene

Homo sapiens

Also known as p24; P24A; RNP24; p24b1; p24beta1

Gene ID: 10959 | Gene type: protein coding

About TMED2

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:123,584,552-123,598,582 (from NCBI)

This gene has 5 transcripts (splice variants), 262 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 170.2), colon (RPKM 110.3) and 25 other tissues.

Summary

Involved in several processes, including Golgi organization; negative regulation of GTPase activity; and protein localization to plasma membrane. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]

TMED2 Products(2)

mRNA	Protein	Name
NM_001321445.2	NP_001308374.1	transmembrane emp24 domain-containing protein 2 isoform 2 precursor
NM_006815.4	NP_006806.1	transmembrane emp24 domain-containing protein 2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10359607	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	17693410	GOA
involved in intracellular protein transport	IDA IDA: Inferred from direct assay	20427317	GOA
involved in negative regulation of GTPase activity	IDA IDA: Inferred from direct assay	10761932	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	20361938	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12237308	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12237308	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	12237308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMED2 Protein Structure

EMP24_GP25L

0
100
201 a.a.

Protein Preferred Names

Protein Names

transmembrane emp24 domain-containing protein 2

coated vesicle membrane protein

Related Diseases

Diseases

Alias

Epiphyseal Dysplasia, Multiple, 3

EDM3	Multiple Epiphyseal Dysplasia 3
Epiphyseal Dysplasia, Multiple, 3, With Or Without Myopathy	Multiple Epiphyseal Dysplasia 3 With Or Without Myopathy
Epiphyseal Dysplasia Multiple 3	Dysplasia, Epiphyseal, Multiple, Type 3

Cardiomyopathy, Dilated, 1m

Dilated Cardiomyopathy 1m	CMD1M
Cardiomyopathy, Dilated 1m	Cardiomyopathy, Dilated, Type 1m

Cardiomyopathy, Familial Hypertrophic, 7

Hypertrophic Cardiomyopathy 7	CMH7
Cardiomyopathy, Familial Hypertrophic 7	Cardiomyopathy, Hypertrophic, 7
Cardiomyopathy, Hypertrophic, Familial, Type 7

B-Lymphoblastic Leukemia/Lymphoma Mll Rearranged

B-Lymphoblastic Leukemia/Lymphoma Kmt2a Rearranged	B Lymphoblastic Leukemia/Lymphoma With T
Mll Rearranged	B-All Kmt2a Rearranged
B-Lymphoblastic Leukemia/Lymphoma With T	Kmt2a Rearranged

Cardiomyopathy, Dilated, 1p

Dilated Cardiomyopathy 1p	CMD1P
Cardiomyopathy, Dilated 1p	Cardiomyopathy, Dilated, Type 1p

Epiphyseal Dysplasia, Multiple, 1

EDM1	Multiple Epiphyseal Dysplasia 1
Multiple Epiphyseal Dysplasia Type 1	Med1
Multiple Epiphyseal Dysplasia Comp-Related	Polyepiphyseal Dysplasia Type 1
Multiple Epiphyseal Dysplasia, Comp-Related	Epiphyseal Dysplasia Multiple 1
Epiphyseal Dysplasia, Multiple 1	Dysplasia, Epiphyseal, Multiple, Type 1

Epiphyseal Dysplasia, Multiple, 2

EDM2	Multiple Epiphyseal Dysplasia 2
Dysplasia, Epiphyseal, Multiple, Type 2

Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly

Ovarian Mucinous Adenocarcinoma

Mucinous Carcinoma Of Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14636	TMED2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TMED2	VGNC	VGNC:80502
Canis familiaris	TMED2	VGNC	VGNC:57417
Rattus norvegicus	TMED2	RGD	RGD:69243
Mus musculus	TMED2	MGD	MGI:1929269

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