2. Gene
  3. TMED2 - transmembrane p24 trafficking protein 2 Gene

TMED2 - transmembrane p24 trafficking protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as p24; P24A; RNP24; p24b1; p24beta1

Gene ID: 10959 | Gene type: protein coding

About TMED2

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:123,584,552-123,598,582 (from NCBI)

This gene has 5 transcripts (splice variants), 262 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 170.2), colon (RPKM 110.3) and 25 other tissues.

Summary

Involved in several processes, including Golgi organization; negative regulation of GTPase activity; and protein localization to plasma membrane. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]

TMED2 Products(2)

mRNA Protein Name
NM_001321445.2 NP_001308374.1 transmembrane emp24 domain-containing protein 2 isoform 2 precursor
NM_006815.4 NP_006806.1 transmembrane emp24 domain-containing protein 2 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10359607 GOA
Biological Process GO Annotation Evidence Reference Source
involved in Golgi organization IMP
IMP: Inferred from mutant phenotype
17693410 GOA
involved in intracellular protein transport IDA
IDA: Inferred from direct assay
20427317 GOA
involved in negative regulation of GTPase activity IDA
IDA: Inferred from direct assay
10761932 GOA
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
20361938 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
12237308 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
12237308 GOA
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: Inferred from direct assay
12237308 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMED2 Protein Structure

EMP24_GP25L

EMP24_GP25L: emp24/gp25L/p24 family/GOLD (23 - 196)

  • 0
  • 100
  • 201 a.a.
Protein Preferred Names Protein Names

transmembrane emp24 domain-containing protein 2

coated vesicle membrane protein

TMED2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TMED2 Q15363 CD59 Homo sapiens P13987
Anti Tag CoIP
20427317
Intra
TMED2 Q15363 CD59 Homo sapiens P13987
Anti Bait CoIP
20427317
Intra
TMED2 Q15363 F2RL1 Homo sapiens P55085
Confocal
17693410
Intra
TMED2 Q15363 F2RL1 Homo sapiens P55085
Pull Down
21219331
Intra
TMED2 Q15363 CASR Homo sapiens P41180
Anti Tag CoIP
20361938
Intra
TMED2 Q15363 TMED10 Homo sapiens P49755
Anti Tag CoIP
35271311
Intra
TMED2 Q15363 TMED10 Homo sapiens P49755
Anti Bait CoIP
18287528
Intra
TMED2 Q15363 TMED10 Homo sapiens P49755
Anti Bait CoIP
12237308
Intra
TMED2 Q15363 TMED10 Homo sapiens P49755
Anti Tag CoIP
33961781
Intra
TMED2 Q15363 TMED10 Homo sapiens P49755
Anti Bait CoIP
16641999
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Epiphyseal Dysplasia, Multiple, 3

EDM3

Multiple Epiphyseal Dysplasia 3

Epiphyseal Dysplasia, Multiple, 3, With Or Without Myopathy

Multiple Epiphyseal Dysplasia 3 With Or Without Myopathy

Epiphyseal Dysplasia Multiple 3

Dysplasia, Epiphyseal, Multiple, Type 3
Cardiomyopathy, Dilated, 1m

Dilated Cardiomyopathy 1m

CMD1M

Cardiomyopathy, Dilated 1m

Cardiomyopathy, Dilated, Type 1m
Cardiomyopathy, Familial Hypertrophic, 7

Hypertrophic Cardiomyopathy 7

CMH7

Cardiomyopathy, Familial Hypertrophic 7

Cardiomyopathy, Hypertrophic, 7

Cardiomyopathy, Hypertrophic, Familial, Type 7
B-Lymphoblastic Leukemia/Lymphoma Mll Rearranged

B-Lymphoblastic Leukemia/Lymphoma Kmt2a Rearranged

B Lymphoblastic Leukemia/Lymphoma With T

Mll Rearranged

B-All Kmt2a Rearranged

B-Lymphoblastic Leukemia/Lymphoma With T

Kmt2a Rearranged
Cardiomyopathy, Dilated, 1p

Dilated Cardiomyopathy 1p

CMD1P

Cardiomyopathy, Dilated 1p

Cardiomyopathy, Dilated, Type 1p
Epiphyseal Dysplasia, Multiple, 1

EDM1

Multiple Epiphyseal Dysplasia 1

Multiple Epiphyseal Dysplasia Type 1

Med1

Multiple Epiphyseal Dysplasia Comp-Related

Polyepiphyseal Dysplasia Type 1

Multiple Epiphyseal Dysplasia, Comp-Related

Epiphyseal Dysplasia Multiple 1

Epiphyseal Dysplasia, Multiple 1

Dysplasia, Epiphyseal, Multiple, Type 1
Epiphyseal Dysplasia, Multiple, 2

EDM2

Multiple Epiphyseal Dysplasia 2

Dysplasia, Epiphyseal, Multiple, Type 2
Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly
Ovarian Mucinous Adenocarcinoma

Mucinous Carcinoma Of Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14636 TMED2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TMED2 VGNC VGNC:80502
Canis familiaris TMED2 VGNC VGNC:57417
Rattus norvegicus TMED2 RGD RGD:69243
Mus musculus TMED2 MGD MGI:1929269