ASCC3 - activating signal cointegrator 1 complex subunit 3 Gene

Homo sapiens

Also known as RNAH; HELIC1; ASC1p200

Gene ID: 10973 | Gene type: protein coding

About ASCC3

Cytogenetic location: 6q16.3 Genomic coordinates (GRCh38): 6:100,508,194-100,881,329 (from NCBI)

This gene has 7 transcripts (splice variants), 205 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in urinary bladder (RPKM 5.0), colon (RPKM 4.9) and 25 other tissues.

Summary

This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ASCC3 Products(3)

mRNA	Protein	Name
NM_001284271.2	NP_001271200.1	activating signal cointegrator 1 complex subunit 3 isoform c
NM_006828.4	NP_006819.2	activating signal cointegrator 1 complex subunit 3 isoform a
NM_022091.5	NP_071374.1	activating signal cointegrator 1 complex subunit 3 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5' DNA helicase activity	IDA IDA: Inferred from direct assay	22055184	GOA
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	32579943	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22055184	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA alkylation repair	IDA IDA: Inferred from direct assay	22055184	GOA
involved in DNA duplex unwinding	IDA IDA: Inferred from direct assay	22055184	GOA
involved in rescue of stalled ribosome	IDA IDA: Inferred from direct assay	32579943	GOA
involved in rescue of stalled ribosome	IMP IMP: Inferred from mutant phenotype	32099016	GOA
involved in ribosome disassembly	IDA IDA: Inferred from direct assay	32579943	GOA
involved in ribosome-associated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	32099016	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of DNA repair complex	IPI IPI: Inferred from physical interaction	29997253	GOA
part of activating signal cointegrator 1 complex	IDA IDA: Inferred from direct assay	12077347	GOA
located in cytosol	IDA IDA: Inferred from direct assay	28757607	GOA
is active in cytosolic ribosome	IDA IDA: Inferred from direct assay	36302773	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12077347	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASCC3 Protein Structure

DEAD

Helicase_C

Sec63

DEAD

Helicase_C

Sec63

0
400
800
1200
1600
2000
2202 a.a.

Protein Preferred Names

Protein Names

activating signal cointegrator 1 complex subunit 3

ASC-1 complex subunit P200

Related Diseases

Diseases

Alias

Large Intestine Adenocarcinoma

Adenocarcinoma Of Large Intestine

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01077	ASCC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ASCC3	VGNC	VGNC:69863
Felis catus	ASCC3	VGNC	VGNC:59968
Mus musculus	ASCC3	MGD	MGI:1925237
Canis familiaris	ASCC3	VGNC	VGNC:38172
Rattus norvegicus	ASCC3	RGD	RGD:1307995
Bos taurus	ASCC3	VGNC	VGNC:26205

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