2. Gene
  3. HCCS - holocytochrome c synthase Gene

HCCS - holocytochrome c synthase Gene

  • Gene
  • Protein
  • Agent
Homo sapiens (human)

Also known as MLS; CCHL; MCOPS7; LSDMCA1

Gene ID: 3052 | Gene type: protein coding

About HCCS

Summary

The protein encoded by this gene is an Enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010]

HCCS Products(1)

mRNA Protein Name
NM_001122608.3 NP_001116080.1 holocytochrome c-type synthase
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables heme binding IDA
IDA: Inferred from direct assay
23150584 GOA
enables holocytochrome-c synthase activity IDA
IDA: Inferred from direct assay
23150584 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cytochrome c-heme linkage IDA
IDA: Inferred from direct assay
23150584 GOA
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
23150584 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
11827457 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

holocytochrome c-type synthase

cytochrome c heme-lyase

cytochrome c-type heme lyase

holocytochrome-c synthetase

microphthalamia with linear skin defects

microphthalmia with linear skin defects

HCCS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HCCS P53701 AGK Homo sapiens Q53H12
Anti Tag CoIP
33961781
Intra
HCCS P53701 AGK Homo sapiens Q53H12
Anti Tag CoIP
28514442
Intra
HCCS P53701 SNX1 Homo sapiens Q13596
Validated Y2H
32296183
Intra
HCCS P53701 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra
HCCS P53701 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Intra
HCCS P53701 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra
HCCS P53701 SENP2 Homo sapiens Q9HC62
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50767 Palbociclib Inhibitor 99.94% Unkown
HY-17386 Rosiglitazone 99.94% Yes
HY-15306 Eltrombopag 99.94% Yes
HY-50767A Palbociclib monohydrochloride Inhibitor 99.98% Unkown
HY-A0065 Palbociclib isethionate Inhibitor 99.99% Unkown
HY-50767C Palbociclib hydrochloride Inhibitor 99.93% Unkown
HY-B0402 Amantadine 99.90% Unkown
HY-N7073 Silymarin Inhibitor 82.50% Unkown
HY-107193 Bacitracin Inhibitor / Yes
HY-15306A Eltrombopag Olamine 99.96% Yes
HY-B0402A Amantadine hydrochloride ≥98.0% Yes
HY-17386A Rosiglitazone hydrochloride 99.31% Yes
HY-100008 Peretinoin 99.79% Yes
HY-N2591 Isocorydine 99.95% Unkown
HY-B0310 Nizatidine Antagonist 99.68% Unkown
HY-17386B Rosiglitazone potassium / Unkown
HY-50767B Palbociclib dihydrochloride Inhibitor / Unkown
HY-50767D Palbociclib orotate Inhibitor / Unkown
HY-B0402B Amantadine sulfate / Unkown
HY-N2591A Isocorydine hydrochloride / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9971 Camrelizumab Inhibitor 98.80% Unkown
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-18750 Zorifertinib 99.37% Phase 3
HY-18750A Zorifertinib hydrochloride / Phase 3
HY-100492 Fisogatinib Inhibitor 99.87% Phase 2
HY-116000 Glumetinib Inhibitor 99.92% Phase 2
HY-16196 ENMD-1198 Inhibitor 98.87% Phase 1
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P99108 Penpulimab Inhibitor 98.80% Phase 4
HY-P99013 Codrituzumab Inhibitor 95.70% Phase 2
HY-P99353 Ascrinvacumab Inhibitor 97.45% Phase 2
Pre-clinical Phase
Bioactive Molecules (153)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N2334 Glycochenodeoxycholic acid 99.25% Unkown
HY-N0751 Scutellarin Inhibitor 99.04% Unkown
HY-16706A Remodelin hydrobromide Inhibitor 99.52% Unkown
HY-131045 HADA hydrochloride 99.08% Unkown
HY-111226 GSK5182 99.85% Unkown
HY-116761 GSK467 Inhibitor 99.55% Unkown
HY-N2334A Glycochenodeoxycholic acid sodium salt 99.36% Unkown
HY-15449 Kaempferide 99.80% Unkown
HY-W015309 Decanoic acid Inhibitor ≥98.0% Unkown
HY-N0070 Solasonine 99.19% Unkown
HY-N0220 Dauricine 99.91% Unkown
HY-12794 Vps34-PIK-III Inhibitor 99.63% Unkown
HY-15897 LDN-212854 Inhibitor 99.70% Unkown
HY-113261 Oleoylcarnitine 99.91% Unkown
HY-111126 K67 Inhibitor 98.26% Unkown
HY-123921 Gefitinib-based PROTAC 3 Inhibitor 99.98% Unkown
HY-N0876 Arenobufagin Inhibitor 99.86% Unkown
HY-N6739 Beauvericin 99.97% Unkown
HY-153360 MC-GGFG-AM-(10Me-11F-Camptothecin) Inhibitor 98.06% Unkown
HY-115449 Chromeceptin 99.80% Unkown
HY-19345A Vacquinol-1 dihydrochloride Activator 99.44% Unkown
HY-147918 Anticancer agent 73 Inhibitor 99.92% Unkown
HY-N0222 Avicularin 99.80% Unkown
HY-19832 SC66 99.47% Unkown
HY-139781 PD-L1-IN-1 Inhibitor 98.01% Unkown
HY-101519 BETd-260 99.59% Unkown
HY-15485 Zardaverine 98.64% Unkown
HY-139434 JMJD6-IN-1 Inhibitor 99.69% Unkown
HY-150538 STAT3-IN-12 99.92% Unkown
HY-P5133 Synstatin (92-119) Inhibitor 99.42% Unkown
HY-121799A Taurohyocholic acid sodium salt 96.80% Unkown
HY-150750 ODN M362 / Unkown
HY-137506 XST-14 99.26% Unkown
HY-132177 α-L-Fucosidase, Microorganism / Unkown
HY-13267 Droxinostat 98.91% Unkown
HY-115901 4-PQBH 99.08% Unkown
HY-W013514 2-Acetamidofluorene Inhibitor 98.83% Unkown
HY-142956 ROS-ERS inducer 1 99.65% Unkown
HY-160765 WNTinib 99.95% Unkown
HY-10174 PD184161 98.08% Unkown
HY-150750A ODN M362 sodium 93.61% Unkown
HY-157581 MS39 Degrader 99.89% Unkown
HY-N6896 Isoviolanthin Inhibitor 99.66% Unkown
HY-131704 FGFR4-IN-5 Inhibitor 98.03% Unkown
HY-121204 Iberverin Inducer ≥98.0% Unkown
HY-130173 Bafilomycin C1 ≥99.0% Unkown
HY-119694 Rotenolone ≥97.0% Unkown
HY-147187 MNK8 99.76% Unkown
HY-150072 DS89002333 Inhibitor 99.87% Unkown
HY-153901 PROTAC EGFR degrader 8 Inhibitor 98.90% Unkown
HY-W001925 7-Methoxy-1-tetralone 99.93% Unkown
HY-W011434 Triglycidyl isocyanurate ≥98.0% Unkown
HY-146349 PROTAC EGFR degrader 4 Inhibitor 99.70% Unkown
HY-155248 HL23 / Unkown
HY-N6623 Malvidin-3-galactoside chloride 99.63% Unkown
HY-157950 DSPE-PEG2000-triGalNAc ammonium 97.4% Unkown
HY-19617 EGFR-IN-1 Inhibitor / Unkown
HY-19617A EGFR-IN-1 hydrochloride Inhibitor / Unkown
HY-119833 Rubone Modulator 99.1% Unkown
HY-162616 SelSA 99.83% Unkown
HY-163490 PKMYT1-IN-1 Inhibitor / Unkown
HY-19617B EGFR-IN-1 TFA Inhibitor 99.38% Unkown
HY-N4168B Methyl chlorogenate 99.13% Unkown
HY-N5136 25(R,S)-Ruscogenin Inhibitor 99.83% Unkown
HY-W011616 Cardionogen 1 Inhibitor 99.21% Unkown
HY-159147 SIA​​IS039 / Unkown
HY-19551 Apogossypolone / Unkown
HY-100443 PX20606 Agonist / Unkown
HY-146407 Anticancer agent 53 Inducer / Unkown
HY-147515 FGFR4-IN-11 Inhibitor / Unkown
HY-151287 KRAS inhibitor-20 Inhibitor / Unkown
HY-101021 Ascochlorin / Unkown
HY-113261R Oleoylcarnitine (Standard) / Unkown
HY-115902 FGFR4-IN-7 / Unkown
HY-120349 LL-Z1640-4 Inhibitor / Unkown
HY-120356 T-1101 / Unkown
HY-121160 Amiprilose Inhibitor / Unkown
HY-141813 Autophagy-IN-C1 Inhibitor / Unkown
HY-142945 KRAS G12C inhibitor 43 Inhibitor / Unkown
HY-143881 FGFR4-IN-6 Inhibitor / Unkown
HY-144605 PROTAC EGFR degrader 3 Inhibitor 97.39% Unkown
HY-144724 HSP90-IN-10 Inhibitor / Unkown
HY-144759 FGFR4-IN-9 Inhibitor / Unkown
HY-145389 SZ-015268 Inhibitor / Unkown
HY-146395 HBV-IN-23 / Unkown
HY-146422 PROTAC EGFR degrader 5 / Unkown
HY-146423 PROTAC EGFR degrader 6 / Unkown
HY-146504 Topoisomerase I/II inhibitor 3 / Unkown
HY-147793 FGFR4-IN-12 Inhibitor / Unkown
HY-149063 Antitumor agent-92 Inducer / Unkown
HY-149475 VEGFR-2-IN-33 Inhibitor / Unkown
HY-150596 CT1-3 / Unkown
HY-151461 CHNQD-01255 Inhibitor / Unkown
HY-155046 FGFR4-IN-14 Inhibitor / Unkown
HY-155139 Tubulin polymerization-IN-45 / Unkown
HY-155172 ZX-J-19j / Unkown
HY-155178 Antiproliferative agent-34 Inhibitor / Unkown
HY-158248 FGFR4-IN-19 Inhibitor / Unkown
HY-158439 anti-TNBC agent-7 Modulator / Unkown
HY-161373 PI3Kα-IN-22 Inhibitor / Unkown
HY-161617 LASSBio-2052 / Unkown
HY-161647 Antitumor agent-156 Inducer / Unkown
HY-161706 c-Fms-IN-15 Inhibitor / Unkown
HY-161824 Antiproliferative agent-52 / Unkown
HY-161825 Tubulin polymerization-IN-66 / Unkown
HY-161854 LASSBio-1911 Inhibitor / Unkown
HY-161934 PARP1-IN-27 / Unkown
HY-162099 VEGFR-IN-4 Inhibitor / Unkown
HY-162259 QC-182 Degrader / Unkown
HY-162650 SL44 Inhibitor / Unkown
HY-162679 c-Met degrader-1 / Unkown
HY-162890 EGFR-IN-122 Inhibitor / Unkown
HY-162968 MRTF-A-IN-1 Inhibitor / Unkown
HY-162969 MRTF-A-IN-2 Inhibitor / Unkown
HY-163461 4F-DDC Inhibitor / Unkown
HY-163491 PKMYT1-IN-2 Inhibitor / Unkown
HY-164349 WZ-2-033 Inhibitor / Unkown
HY-164372 17-Demethoxy-reblastatin / Unkown
HY-164410 MO-I-1100 Inhibitor / Unkown
HY-168085 CV-4-26 / Unkown
HY-168165 Adefovir diphosphate / Unkown
HY-168187 Src Inhibitor 3 Inhibitor / Unkown
HY-168337 SET-171 Inhibitor / Unkown
HY-168574 SZU-B6 / Unkown
HY-168609 CRI9 / Unkown
HY-168872 API32 Inhibitor / Unkown
HY-169262 PLD-IN-1 / Unkown
HY-169431 VEGFR-2/AKT-IN-2 / Unkown
HY-170549 VEGFR-2-IN-60 Inhibitor / Unkown
HY-170651 CDK4/6/HDAC-IN-1 / Unkown
HY-170690 FGFR4-IN-22 Inhibitor / Unkown
HY-170791 CIB-L43 / Unkown
HY-172394 ZSNI-21 Inhibitor / Unkown
HY-173038 EGFR-IN-151 / Unkown
HY-173060 ERK1/2 inhibitor 13 / Unkown
HY-19345 Vacquinol-1 Activator / Unkown
HY-D2312 Mito-Rh-S / Unkown
HY-E70272 2-Hydroxystearoyl-CoA / Unkown
HY-N11429 Glycochenodeoxycholic acid 3-glucuronide / Unkown
HY-N1244 Sarmentosin / Unkown
HY-N1260 Scutebarbatine A Inducer 98.76% Unkown
HY-N12601 Diselaginellin B Inducer / Unkown
HY-N7803 De-O-Methyllasiodiplodin Inducer / Unkown
HY-N8439 Questiomycin A 98.20% Unkown
HY-P10553 ARF(26–44), cell-permeable / Unkown
HY-W653905 Amantadine-d15 hydrochloride / Unkown
HY-121799 Taurohyocholic acid / Unkown
HY-123697 VE-465 Inhibitor / Unkown
HY-164384 DFX117 / Unkown
HY-164520 PMED-1 Inhibitor / Unkown
HY-17386S1 Rosiglitazone-d4 / Unkown
HY-N2858 Alpinumisoflavone acetate Inducer / Unkown
HY-N7507A Sempervirine nitrate Inhibitor / Unkown