2. Gene
  3. TOPBP1 - DNA topoisomerase II binding protein 1 Gene

TOPBP1 - DNA topoisomerase II binding protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Dpb11; TOP2BP1

Gene ID: 11073 | Gene type: protein coding

About TOPBP1

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:133,600,238-133,661,941 (from NCBI)

This gene has 10 transcripts (splice variants), 199 orthologues and 1 paralogue. Broad expression in testis (RPKM 16.9), bone marrow (RPKM 13.6) and 25 other tissues.

Summary

This gene encodes a binding protein which interacts with the C-terminal region of Topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of Topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]

TOPBP1 Products(2)

mRNA Protein Name
NM_001363889.2 NP_001350818.1 DNA topoisomerase 2-binding protein 1 isoform 2
NM_007027.4 NP_008958.2 DNA topoisomerase 2-binding protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin-protein adaptor activity IDA
IDA: Inferred from direct assay
17575048 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
17006541 GOA
enables phosphorylation-dependent protein binding IDA
IDA: Inferred from direct assay
17575048 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12773567 GOA
enables protein serine/threonine kinase activator activity IDA
IDA: Inferred from direct assay
21777809 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage checkpoint signaling IDA
IDA: Inferred from direct assay
17575048 GOA
involved in DNA damage response IDA
IDA: Inferred from direct assay
12773567 GOA
involved in DNA replication checkpoint signaling IDA
IDA: Inferred from direct assay
21482717 GOA
involved in broken chromosome clustering IDA
IDA: Inferred from direct assay
37165191 GOA
involved in chromosome organization IDA
IDA: Inferred from direct assay
35121901 GOA
involved in double-strand break repair via alternative nonhomologous end joining IDA
IDA: Inferred from direct assay
37674080 GOA
involved in double-strand break repair via classical nonhomologous end joining IDA
IDA: Inferred from direct assay
31135337 GOA
involved in double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
26811421 GOA
involved in protein localization to site of double-strand break IDA
IDA: Inferred from direct assay
26811421 GOA
involved in response to ionizing radiation IDA
IDA: Inferred from direct assay
12773567 GOA
Cellular Component GO Annotation Evidence Reference Source
part of BRCA1-B complex IPI
IPI: Inferred from physical interaction
16391231 GOA
located in PML body IDA
IDA: Inferred from direct assay
12773567 GOA
is active in chromosome IDA
IDA: Inferred from direct assay
35121901 GOA
located in chromosome IDA
IDA: Inferred from direct assay
21659603 GOA
is active in site of DNA damage IDA
IDA: Inferred from direct assay
21777809 GOA
is active in site of double-strand break IDA
IDA: Inferred from direct assay
26811421 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOPBP1 Protein Structure

BRCT

BRCT: BRCA1 C Terminus (BRCT) domain (106 - 174)

PTCB-BRCT

PTCB-BRCT: twin BRCT domain (203 - 266)

BRCT

BRCT: BRCA1 C Terminus (BRCT) domain (356 - 431)

PTCB-BRCT

PTCB-BRCT: twin BRCT domain (649 - 720)

BRCT

BRCT: BRCA1 C Terminus (BRCT) domain (902 - 977)

BRCT

BRCT: BRCA1 C Terminus (BRCT) domain (1265 - 1337)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1522 a.a.
Protein Preferred Names Protein Names

DNA topoisomerase 2-binding protein 1

DNA topoisomerase II-beta-binding protein 1

Related Diseases

Diseases Alias
Ataxia-Telangiectasia

Ataxia Telangiectasia

Louis-Bar Syndrome

AT

At1

Ataxia-Telangiectasia Syndrome

Ataxia - Telangiectasia Variant

Boder-Sedgwick Syndrome

Louis Bar Syndrome

Cerebello-Oculocutaneous Telangiectasia

Immunodeficiency With Ataxia Telangiectasia

A-T

Ataxia Telangiectasia Syndrome

Atm

Telangiectasia, Cerebello-Oculocutaneous

Ataxia-Telangiectasia Variant
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Seckel Syndrome

Microcephalic Primordial Dwarfism

Bird-Headed Dwarfism

Harper'S Syndrome

Virchow-Seckel Dwarfism

Nanocephalic Dwarfism

Sckl

Seckel-Type Dwarfism
Pulmonary Venoocclusive Disease

Pulmonary Veno-Occlusive Disease

Obstructive Disease Of The Pulmonary Veins

Pvod

Isolated Pulmonary Venous Sclerosis

Venous Form Of Primary Pulmonary Hypertension

Pulmonary Venoocclusive Disease 1, Autosomal Dominant
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum
Aplastic Anemia

Aplastic Anemia, Susceptibility To

Anemia Aplastic

Idiopathic Aplastic Anemia

Secondary Aplastic Anemia

Idiopathic Bone Marrow Failure

Aplastic Anemia Idiopathic

AA

Anemia, Aplastic

Aplastic Anemia, Idiopathic

Erythroid Aplasia

Aa - [Aplastic Anaemia]

Haematopoietic Aplasia

Aleukia Haemorrhagica

Anaemia Due To Decreased Red Cell Production

Aplasia Bone Marrow

Aplastic Bone Marrow

Hypoplastic Anaemia Nos

Myeloid Bone Marrow Aplasia

Pancytopenia

Panhaematopenia

Hypoproliferative Anaemia

Medullary Hypoplasia

Red Blood Cells Hypoplastic Anaemia

Panmyelophthisis

Panhemocytopenia

Refractive Hypoproliferative Anaemia

Toxic Anaemia

Toxic Aplastic Anaemia

Aplastic Anaemia Due To Toxic Cause

Idiopathic Aplastic Anaemia Nos
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly
Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-160409 TopBP1-IN-1 / Unkown
HY-RS14901 TOPBP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TOPBP1 VGNC VGNC:49635
Bos taurus TOPBP1 VGNC VGNC:49585
Macaca mulatta TOPBP1 VGNC VGNC:79061
Rattus norvegicus TOPBP1 RGD RGD:1562949
Felis catus TOPBP1 VGNC VGNC:66452
Mus musculus TOPBP1 MGD MGI:1920018