TOPBP1 - DNA topoisomerase II binding protein 1 Gene

Homo sapiens

Also known as Dpb11; TOP2BP1

Gene ID: 11073 | Gene type: protein coding

About TOPBP1

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:133,600,238-133,661,941 (from NCBI)

This gene has 10 transcripts (splice variants), 199 orthologues and 1 paralogue. Broad expression in testis (RPKM 16.9), bone marrow (RPKM 13.6) and 25 other tissues.

Summary

This gene encodes a binding protein which interacts with the C-terminal region of Topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of Topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]

TOPBP1 Products(2)

mRNA	Protein	Name
NM_001363889.2	NP_001350818.1	DNA topoisomerase 2-binding protein 1 isoform 2
NM_007027.4	NP_008958.2	DNA topoisomerase 2-binding protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin-protein adaptor activity	IDA IDA: Inferred from direct assay	17575048	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17006541	GOA
enables phosphorylation-dependent protein binding	IDA IDA: Inferred from direct assay	17575048	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12773567	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	21777809	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage checkpoint signaling	IDA IDA: Inferred from direct assay	17575048	GOA
involved in DNA damage response	IDA IDA: Inferred from direct assay	12773567	GOA
involved in DNA replication checkpoint signaling	IDA IDA: Inferred from direct assay	21482717	GOA
involved in broken chromosome clustering	IDA IDA: Inferred from direct assay	37165191	GOA
involved in chromosome organization	IDA IDA: Inferred from direct assay	35121901	GOA
involved in double-strand break repair via alternative nonhomologous end joining	IDA IDA: Inferred from direct assay	37674080	GOA
involved in double-strand break repair via classical nonhomologous end joining	IDA IDA: Inferred from direct assay	31135337	GOA
involved in double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	26811421	GOA
involved in protein localization to site of double-strand break	IDA IDA: Inferred from direct assay	26811421	GOA
involved in response to ionizing radiation	IDA IDA: Inferred from direct assay	12773567	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of BRCA1-B complex	IPI IPI: Inferred from physical interaction	16391231	GOA
located in PML body	IDA IDA: Inferred from direct assay	12773567	GOA
is active in chromosome	IDA IDA: Inferred from direct assay	35121901	GOA
located in chromosome	IDA IDA: Inferred from direct assay	21659603	GOA
is active in site of DNA damage	IDA IDA: Inferred from direct assay	21777809	GOA
is active in site of double-strand break	IDA IDA: Inferred from direct assay	26811421	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOPBP1 Protein Structure

BRCT

PTCB-BRCT

BRCT

PTCB-BRCT

BRCT

0
300
600
900
1200
1522 a.a.

Protein Preferred Names

Protein Names

DNA topoisomerase 2-binding protein 1

DNA topoisomerase II-beta-binding protein 1

TOPBP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TOPBP1	Q92547	E2	Human papillomavirus	P03120	Anti Tag CoIP	17006541
Intra	TOPBP1	Q92547	E2	Human papillomavirus	P03120	CoIP	11934899
Intra	TOPBP1	Q92547	E2F1	Homo sapiens	Q01094	Pull Down	14576432
Intra	TOPBP1	Q92547	TCF20	Homo sapiens	Q9UGU0	Anti Tag CoIP	17913746
Intra	TOPBP1	Q92547	E2F1	Homo sapiens	Q01094	Anti Bait CoIP	17006541
Intra	TOPBP1	Q92547	TCF20	Homo sapiens	Q9UGU0	Pull Down	17913746
Intra	TOPBP1	Q92547	TCF20	Homo sapiens	Q9UGU0	Anti Bait CoIP	17913746
Intra	TOPBP1	Q92547	CDC45	Homo sapiens	O75419	Anti Bait CoIP	17887956
Intra	TOPBP1	Q92547	TCF20	Homo sapiens	Q9UGU0	Y2H	17913746
Intra	TOPBP1	Q92547	E2F1	Homo sapiens	Q01094	Pull Down	17006541

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ataxia-Telangiectasia

Ataxia Telangiectasia	Louis-Bar Syndrome
AT	At1
Ataxia-Telangiectasia Syndrome	Ataxia - Telangiectasia Variant
Boder-Sedgwick Syndrome	Louis Bar Syndrome
Cerebello-Oculocutaneous Telangiectasia	Immunodeficiency With Ataxia Telangiectasia
A-T	Ataxia Telangiectasia Syndrome
Atm	Telangiectasia, Cerebello-Oculocutaneous
Ataxia-Telangiectasia Variant

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Pulmonary Venoocclusive Disease

Pulmonary Veno-Occlusive Disease	Obstructive Disease Of The Pulmonary Veins
Pvod	Isolated Pulmonary Venous Sclerosis
Venous Form Of Primary Pulmonary Hypertension	Pulmonary Venoocclusive Disease 1, Autosomal Dominant

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160409	TopBP1-IN-1	Inhibitor	98.35%	Unkown
HY-RS14901	TOPBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TOPBP1	VGNC	VGNC:49635
Bos taurus	TOPBP1	VGNC	VGNC:49585
Macaca mulatta	TOPBP1	VGNC	VGNC:79061
Rattus norvegicus	TOPBP1	RGD	RGD:1562949
Felis catus	TOPBP1	VGNC	VGNC:66452
Mus musculus	TOPBP1	MGD	MGI:1920018

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