1. Gene
  2. E2F1 - E2F transcription factor 1 Gene

E2F1 - E2F transcription factor 1 Gene

Homo sapiens

Also known as RBP3; E2F-1; RBAP1; RBBP3

Gene ID: 1869 | Gene type: protein coding

About E2F1

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:33,675,477-33,686,385 (from NCBI)

This gene has 1 transcript (splice variant), 200 orthologues and 7 paralogues. Broad expression in bone marrow (RPKM 12.7), testis (RPKM 5.6) and 17 other tissues.

Summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic Amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent Apoptosis. [provided by RefSeq, Jul 2008]

E2F1 Products(1)

mRNA Protein Name
NM_005225.3 NP_005216.1 transcription factor E2F1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
15073182 GOA
enables DNA binding IMP
IMP: Inferred from mutant phenotype
11418595 GOA
enables DNA-binding transcription activator activity IDA
IDA: Inferred from direct assay
17062573 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15731768 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
20040599 GOA
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
16360038 GOA
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15735762 GOA
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
16360038 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7784053 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23332764 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
12717439 GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
12717439 GOA
involved in mRNA stabilization IDA
IDA: Inferred from direct assay
15766563 GOA
involved in negative regulation of DNA binding IDA
IDA: Inferred from direct assay
20176812 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
20176812 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20224733 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
21454377 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
15565177 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
15565177 GOA
involved in positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
20224733 GOA
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
15766563 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
28992046 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20040599 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
1531329 GOA
acts upstream of regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
20224733 GOA
Cellular Component GO Annotation Evidence Reference Source
part of RNA polymerase II transcription regulator complex IPI
IPI: Inferred from physical interaction
16360038 GOA
part of Rb-E2F complex IDA
IDA: Inferred from direct assay
20224733 GOA
part of Rb-E2F complex IPI
IPI: Inferred from physical interaction
16360038 GOA
located in chromatin IDA
IDA: Inferred from direct assay
21454377 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
28992046 GOA
located in nucleus IDA
IDA: Inferred from direct assay
1531329 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
23629655 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

E2F1 Protein Structure

E2F_TDP

E2F_TDP: E2F/DP family winged-helix DNA-binding domain (127 - 192)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 437 a.a.
Protein Preferred Names Protein Names

transcription factor E2F1

PBR3

E2F1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra E2F1 Q01094 STAT1 Homo sapiens P42224
Display Tech
20195357
Intra E2F1 Q01094 MCPH1 Homo sapiens Q8NEM0
BiFC
18660752
Intra E2F1 Q01094 MCPH1 Homo sapiens Q8NEM0
Anti Bait CoIP
18660752
Cross E2F1 Q01094 Sirt1 Mus musculus Q923E4
Anti Tag CoIP
16892051
Cross E2F1 Q01094 Sirt1 Mus musculus Q923E4
Anti Bait CoIP
16892051
Intra E2F1 Q01094 SIRT1 Homo sapiens Q96EB6
Anti Bait CoIP
16892051
Intra E2F1 Q01094 L3MBTL3 Homo sapiens Q96JM7
Anti Tag CoIP
17517653
Intra E2F1 Q01094 SP1 Homo sapiens P08047
Pull Down
8657141
Intra E2F1 Q01094 TOPBP1 Homo sapiens Q92547
Anti Tag CoIP
17006541
Intra E2F1 Q01094 PRMT5 Homo sapiens O14744
Anti Bait CoIP
22327218
Intra E2F1 Q01094 PRMT5 Homo sapiens O14744
Pull Down
22327218
Intra E2F1 Q01094 PRMT5 Homo sapiens O14744
Anti Tag CoIP
22327218
Intra E2F1 Q01094 RRP1B Homo sapiens Q14684
Anti Bait CoIP
20040599
Intra E2F1 Q01094 CDK8 Homo sapiens P49336
Anti Bait CoIP
18794899
Intra E2F1 Q01094 KAT2A Homo sapiens Q92830
Anti Bait CoIP
20972224
Intra E2F1 Q01094 KAT2A Homo sapiens Q92830
BioID
35140242
Intra E2F1 Q01094 KAT2A Homo sapiens Q92830
Anti Bait CoIP
24502362
Intra E2F1 Q01094 RB1 Homo sapiens P06400
Affinity Chrom
35140242
Intra E2F1 Q01094 RB1 Homo sapiens P06400
Anti Bait CoIP
20871633
Intra E2F1 Q01094 RB1 Homo sapiens P06400
Anti Tag CoIP
34591642
Intra E2F1 Q01094 RB1 Homo sapiens P06400
Anti Bait CoIP
17380128
Intra E2F1 Q01094 RB1 Homo sapiens P06400
ITC
16360038
Intra E2F1 Q01094 RB1 Homo sapiens P06400
Anti Bait CoIP
19249677
Intra E2F1 Q01094 RB1 Homo sapiens P06400
Y2H
29521627
Intra E2F1 Q01094 RB1 Homo sapiens P06400
Pull Down
16374512
Intra E2F1 Q01094 RB1 Homo sapiens P06400
SPR
12502741
Intra E2F1 Q01094 RB1 Homo sapiens P06400
Anti Tag CoIP
17380128
Intra E2F1 Q01094 RB1 Homo sapiens P06400
X-Ray Diffraction
16360038
Intra E2F1 Q01094 RB1 Homo sapiens P06400
Pull Down
16360038
Intra E2F1 Q01094 RB1 Homo sapiens P06400
BioID
35140242
Intra E2F1 Q01094 PAWR Homo sapiens Q96IZ0
Anti Tag CoIP
18660514
Intra E2F1 Q01094 PAWR Homo sapiens Q96IZ0
Anti Bait CoIP
18660514
Intra E2F1 Q01094 TFDP1 Homo sapiens Q14186
Anti Tag CoIP
22327218
Intra E2F1 Q01094 TFDP1 Homo sapiens Q14186
Pull Down
22327218
Intra E2F1 Q01094 TFDP1 Homo sapiens Q14186
ITC
16360038
Intra E2F1 Q01094 TFDP1 Homo sapiens Q14186
Y2H Array
20211142
Intra E2F1 Q01094 TFDP1 Homo sapiens Q14186
Anti Tag CoIP
34591642
Intra E2F1 Q01094 TFDP1 Homo sapiens Q14186
BioID
35140242
Intra E2F1 Q01094 TFDP1 Homo sapiens Q14186
X-Ray Diffraction
16360038
Intra E2F1 Q01094 TFDP1 Homo sapiens Q14186
Affinity Chrom
35140242
Intra E2F1 Q01094 TFDP1 Homo sapiens Q14186
NMR
16360038
Intra E2F1 Q01094 TFDP1 Homo sapiens Q14186
Pull Down
16360038
Cross E2F1 Q01094 E7 Human papillomavirus P03129
Pull Down
11713253
Cross E2F1 Q01094 E7 Human papillomavirus P03129
Affinity Chrom
16061792
Cross E2F1 Q01094 E7 Human papillomavirus P03129
Anti Tag CoIP
11713253
Intra E2F1 Q01094 BTG3 Homo sapiens Q14201
Anti Bait CoIP
17690688
Intra E2F1 Q01094 BTG3 Homo sapiens Q14201
Pull Down
17690688
Intra E2F1 Q01094 BTG3 Homo sapiens Q14201
Anti Tag CoIP
17690688
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms

Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Squamous Cell Skin Cancer

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin

Epilepsy, Idiopathic Generalized 3

EIG3

Idiopathic Generalized Epilepsy 3

Epilepsy, Idiopathic Generalized, Susceptibility To, 3

Epilepsy, Idiopathic Generalized Locus On Chromosome 9

Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 9

Epilepsy, Idiopathic Generalized, Susceptibility To 3

Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Ataxia-Telangiectasia

Ataxia Telangiectasia

Louis-Bar Syndrome

AT

At1

Ataxia-Telangiectasia Syndrome

Ataxia - Telangiectasia Variant

Boder-Sedgwick Syndrome

Louis Bar Syndrome

Cerebello-Oculocutaneous Telangiectasia

Immunodeficiency With Ataxia Telangiectasia

A-T

Ataxia Telangiectasia Syndrome

Atm

Telangiectasia, Cerebello-Oculocutaneous

Ataxia-Telangiectasia Variant

Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Retinal Cancer

Malignant Neoplasm Of Retina

Retinal Neoplasms

Malignant Retinal Neoplasm

Malignant Tumor Of Retina

Neoplasm Of Retina

Retinal Tumor

Retinal Neoplasm

Cancer Of The Retina

Malignant Retinal Tumour

Malignant Tumour Of Retina

Primary Malignant Neoplasm Of Retina

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Pharyngoconjunctival Fever

Pharyngo-Conjunctival Fever

Adenoviral Pharyngoconjunctivitis

Adenovirus Infections, Human

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson Gilford Progeria Syndrome

Hutchinson-Gilford Disease

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome

Atrophy Of Testis

Atrophic Testicle

Atrophy Of Testicle

Testicular Atrophy

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

Ocular Cancer

Eye Neoplasm

Eye Carcinoma

Eye Cancer

Eye Neoplasms

Malignant Eye Neoplasm

Neoplasm Of Eye

Neoplasm Of Eye Proper

Ocular Tumor

Carcinoma Of Eye

Ocular Carcinoma

Malignant Tumor Of Eye

Bilateral Retinoblastoma
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Osteogenic Sarcoma

Osteosarcoma

OSRC

Osteosarcoma, Somatic

Neoplasms, Bone Tissue

Bone Tissue Neoplasm

Osteoid Sarcoma

Skeletal Sarcoma

Osteosarcoma Of Bone

Bone Sarcoma

Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Nijmegen Breakage Syndrome

Berlin Breakage Syndrome

NBS

Microcephaly, Normal Intelligence And Immunodeficiency

Ataxia-Telangiectasia Variant

Ataxia-Telangiectasia Variant V1

Seemanova Syndrome Ii

Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome

Seemanova Syndrome Type 2

At-V1

Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies

Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence

Immunodeficiency, Microcephaly, And Chromosomal Instability

Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome

Microcephaly Immunodeficiency Lymphoreticuloma

Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies

Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence

Seemanova Syndrome 2

Ataxia-Telangiectasia Variant 1

Seemanova Syndrome

At V1

Ataxia-Telangiectasia, Variant 1

Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome

V-At

Ataxia Telangiectasia Variant V1

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Retinal Disease

Retinal Diseases

Retinal Disorder

Retinal Disorders

High Grade Glioma

Malignant Glioma

Glial Cell Tumor

Glioma, Malignant

Malignant Neuroglial Tumor

Neuroglial Tumor

Glioma

Malignant Gliomas

Soft Palate Cancer

Malignant Tumor Of Soft Palate

Malignant Tumor Of The Soft Palate

Palate Cancer Soft Palate

Sensory System Disease
Polycystic Kidney Disease

Polycystic Kidney Diseases

Pkd

Polycystic Renal Disease

Kidney Disease, Polycystic

Polycystic Kidney, Autosomal Dominant

Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy

Gastrointestinal Stromal Tumor

GIST

Gastrointestinal Stromal Tumors

Gastrointestinal Stromal Sarcoma

Gastrointestinal Stromal Tumor, Familial

Gant

Gastrointestinal Stromal Tumour

Stromal Tumor Of Gastrointestinal Tract

Stromal Tumour Of Gastrointestinal Tract

Gastrointestinal Stromal Neoplasm

Paraganglioma And Gastric Stromal Sarcoma

Plexosarcoma

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma

Melanoma, Cutaneous Malignant 1

Familial Melanoma

Melanoma, Cutaneous Malignant, Susceptibility To, 1

Melanoma, Malignant

CMM1

Melanoma, Cutaneous Malignant

Cmm

Familial Atypical Mole-Malignant Melanoma Syndrome

Fammm

Melanoma, Familial

Mlm

Dysplastic Nevus Syndrome, Hereditary

Dns

B-K Mole Syndrome

Melanoma, Cutaneous Malignant, 1

Malignant Melanoma, Cutaneous

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

Dysplastic Nevus Syndrome

Cutaneous Melanoma

Familial Atypical Mole Melanoma Syndrome

Hereditary Melanoma

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus E2F1 RGD RGD:728892
Macaca mulatta E2F1 VGNC VGNC:72022
Mus musculus E2F1 MGD MGI:101941
Felis catus E2F1 VGNC VGNC:61694
Bos taurus E2F1 VGNC VGNC:28286