ESM1 - endothelial cell specific molecule 1 Gene

Homo sapiens

Also known as endocan

Gene ID: 11082 | Gene type: protein coding

About ESM1

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:54,977,867-54,985,593 (from NCBI)

This gene has 4 transcripts (splice variants) and 196 orthologues. Biased expression in thyroid (RPKM 12.6), kidney (RPKM 8.9) and 9 other tissues.

Summary

This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

ESM1 Products(2)

mRNA	Protein	Name
NM_001135604.2	NP_001129076.1	endothelial cell-specific molecule 1 isoform b precursor
NM_007036.5	NP_008967.1	endothelial cell-specific molecule 1 isoform a precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables hepatocyte growth factor receptor binding	IPI IPI: Inferred from physical interaction	11590178	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	11544294	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IEP IEP: Inferred from expression pattern	11866539	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11590178	GOA
involved in positive regulation of hepatocyte growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	11590178	GOA
involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	20616313	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ESM1 Protein Structure

IGFBP

0
100
184 a.a.

Protein Preferred Names

Protein Names

endothelial cell-specific molecule 1

ESM-1

Recombinant ESM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70151	ESM-1 Protein, Human (HEK293, His)	AAH11989.1/Q9NQ30-1 (W20-R184 )	≥95%
HY-P75219	ESM-1 Protein, Human (sf9, His)	Q9NQ30-1/NP_008967.1 (W20-R184)	≥95%

Related Diseases

Diseases

Alias

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04526	ESM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ESM1	VGNC	VGNC:40474
Bos taurus	ESM1	VGNC	VGNC:28602
Mus musculus	ESM1	MGD	MGI:1918940
Macaca mulatta	ESM1	VGNC	VGNC:72431
Rattus norvegicus	ESM1	RGD	RGD:71013
Felis catus	ESM1	VGNC	VGNC:61962
Others	ESM1	NCBI

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