BTN3A2 - butyrophilin subfamily 3 member A2 Gene

Homo sapiens

Also known as BTF4; BT3.2; CD277; BTN3.2

Gene ID: 11118 | Gene type: protein coding

About BTN3A2

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,365,169-26,378,320 (from NCBI)

This gene has 19 transcripts (splice variants), 33 orthologues and 15 paralogues. Ubiquitous expression in spleen (RPKM 42.7), appendix (RPKM 22.0) and 24 other tissues.

Summary

This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the Other family members on chromosome 6. The encoded protein may be involved in the adaptive immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

BTN3A2 Products(5)

mRNA	Protein	Name
NM_001197246.2	NP_001184175.1	butyrophilin subfamily 3 member A2 isoform a precursor
NM_001197247.3	NP_001184176.1	butyrophilin subfamily 3 member A2 isoform a precursor
NM_001197248.3	NP_001184177.1	butyrophilin subfamily 3 member A2 isoform b
NM_001197249.3	NP_001184178.1	butyrophilin subfamily 3 member A2 isoform c
NM_007047.5	NP_008978.2	butyrophilin subfamily 3 member A2 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	29339503	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell mediated immunity	IMP IMP: Inferred from mutant phenotype	22767497	GOA
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	21918970	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	22767497	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTN3A2 Protein Structure

V-set

0
100
200
300
334 a.a.

Protein Preferred Names

Protein Names

butyrophilin subfamily 3 member A2

butyrophilin protein

BTN3A2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BTN3A2	P78410	BTN3A1	Homo sapiens	O00481	Anti Tag CoIP	33961781
Intra	BTN3A2	P78410	BTN3A1	Homo sapiens	O00481	Confocal	29339503
Intra	BTN3A2	P78410	BTN3A1	Homo sapiens	O00481	Anti Tag CoIP	29339503
Intra	BTN3A2	P78410	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	BTN3A2	P78410	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	BTN3A2	P78410	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BTN3A2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7684	BTN3A2 Protein, Human (HEK293, His)	P78410-1 (Q30-W248)	≥95%
HY-P72346	BTN3A2 Protein, Human (Biotinylated, HEK293, His-Avi)	P78410-1 (Q30-W248)	≥95%
HY-P78367	BTN3A2 Protein, Human (HEK293, His-Avi)	P78410-1 (Q30-W248)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01674	BTN3A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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