NUDT5 - nudix hydrolase 5 Gene

Homo sapiens

Also known as YSA1; YSA1H; YSAH1; hNUDT5

Gene ID: 11164 | Gene type: protein coding

About NUDT5

Cytogenetic location: 10p14 Genomic coordinates (GRCh38): 10:12,165,330-12,195,891 (from NCBI)

This gene has 9 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 12.0), skin (RPKM 11.4) and 25 other tissues.

Summary

This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded Enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]

NUDT5 Products(3)

mRNA	Protein	Name
NM_001321647.2	NP_001308576.1	ADP-sugar pyrophosphatase isoform 2
NM_001321648.2	NP_001308577.1	ADP-sugar pyrophosphatase isoform 3
NM_014142.4	NP_054861.2	ADP-sugar pyrophosphatase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 8-oxo-dGDP phosphatase activity	IDA IDA: Inferred from direct assay	19699693	GOA
enables ADP-ribose diphosphatase activity	EXP EXP: Inferred from Experiment	17052728	GOA
enables ADP-ribose diphosphatase activity	IDA IDA: Inferred from direct assay	21389046	GOA
enables ADP-sugar diphosphatase activity	IDA IDA: Inferred from direct assay	10567213	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	18462755	GOA
enables nucleotidyltransferase activity	IDA IDA: Inferred from direct assay	27257257	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27257257	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	27257257	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ATP generation from poly-ADP-D-ribose	IDA IDA: Inferred from direct assay	27257257	GOA
involved in D-ribose catabolic process	IDA IDA: Inferred from direct assay	21389046	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	27257257	GOA
involved in ribonucleoside diphosphate catabolic process	IDA IDA: Inferred from direct assay	18462755	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	27257257	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDT5 Protein Structure

NUDIX

0
100
200
219 a.a.

Protein Preferred Names

Protein Names

ADP-sugar pyrophosphatase

8-oxo-dGDP phosphatase

NUDT5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUDT5	Q9UKK9	PPAT	Homo sapiens	Q06203	Anti Tag CoIP	33961781
Intra	NUDT5	Q9UKK9	PYCR1	Homo sapiens	P32322	Anti Tag CoIP	33961781
Intra	NUDT5	Q9UKK9	NUDT5	Homo sapiens	Q9UKK9	Validated Y2H	32296183
Intra	NUDT5	Q9UKK9	NUDT5	Homo sapiens	Q9UKK9	Y2H Array	32296183
Intra	NUDT5	Q9UKK9	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	NUDT5	Q9UKK9	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	NUDT5	Q9UKK9	NUDT5	Homo sapiens	Q9UKK9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NUDT5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76525	NUDT5 Protein, Human (His)	Q9UKK9 (E2-F219)	≥95%

Related Diseases

Diseases

Alias

Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures

CONDSIAS

Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16965	TH287	Inhibitor	98.29%	Unkown
HY-125209	TH5427		99.92%	Unkown
HY-125209A	TH5427 hydrochloride	Inhibitor	/	Unkown
HY-158318	NUDT5/14 antagonist 1	Inhibitor	/	Unkown
HY-RS09673	NUDT5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-16965A	TH287 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NUDT5	VGNC	VGNC:32339
Canis familiaris	NUDT5	VGNC	VGNC:44034
Rattus norvegicus	NUDT5	RGD	RGD:1359284
Macaca mulatta	NUDT5	VGNC	VGNC:75552
Mus musculus	NUDT5	MGD	MGI:1858232
Others	NUDT5	NCBI

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