KLK8 - kallikrein related peptidase 8 Gene

Homo sapiens

Also known as NP; HNP; NRPN; PRSS19; TADG14

Gene ID: 11202 | Gene type: protein coding

About KLK8

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:50,996,008-51,001,604 (from NCBI)

This gene has 12 transcripts (splice variants), 108 orthologues and 12 paralogues. Biased expression in skin (RPKM 32.0) and esophagus (RPKM 29.8).

Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian Cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

KLK8 Products(5)

mRNA	Protein	Name
NM_001281431.2	NP_001268360.1	kallikrein-8 isoform 5
NM_007196.4	NP_009127.1	kallikrein-8 isoform 1 preproprotein
NM_144505.3	NP_653088.1	kallikrein-8 isoform 2 precursor
NM_144506.3	NP_653089.1	kallikrein-8 isoform 3 precursor
NM_144507.3	NP_653090.1	kallikrein-8 isoform 4

KLK8 Protein Structure

Trypsin

0
100
200
260 a.a.

Protein Preferred Names

Protein Names

kallikrein-8

ovasin

Recombinant KLK8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70169	Kallikrein-8 Protein, Human (232a.a, HEK293, His)	AAH40887.1 (Q29-G260)	≥95%
HY-P73265	Kallikrein-8 Protein, Human (260a.a, HEK293, His)	O60259-1 (M1-G260)	≥95%

Related Diseases

Diseases

Alias

Keratosis

Actinic Keratosis

Hyperkeratosis

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Psoriasis

Granulomatous Angiitis

Vasculitis, Central Nervous System

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148949A	Kallikrein 5-IN-2 TFA	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KLK8	VGNC	VGNC:67968
Bos taurus	KLK8	VGNC	VGNC:30682
Mus musculus	KLK8	MGD	MGI:1343327
Rattus norvegicus	KLK8	RGD	RGD:1305998
Macaca mulatta	KLK8	VGNC	VGNC:74194
Others	KLK8	NCBI

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