SAT2 - spermidine/spermine N1-acetyltransferase family member 2 Gene

Homo sapiens

Also known as SSAT2; SSAT-2

Gene ID: 112483 | Gene type: protein coding

About SAT2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,626,234-7,627,876 (from NCBI)

This gene has 14 transcripts (splice variants), 98 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 97.2), duodenum (RPKM 89.6) and 25 other tissues.

Summary

Enables diamine N-acetyltransferase activity and identical protein binding activity. Involved in polyamine metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

SAT2 Products(4)

mRNA	Protein	Name
NM_001320845.1	NP_001307774.1	thialysine N-epsilon-acetyltransferase isoform 1
NM_001320846.1	NP_001307775.1	thialysine N-epsilon-acetyltransferase isoform 2
NM_001320847.2	NP_001307776.1	thialysine N-epsilon-acetyltransferase isoform 4
NM_133491.5	NP_597998.1	thialysine N-epsilon-acetyltransferase isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables N-acetyltransferase activity	IDA IDA: Inferred from direct assay	15283699	GOA
NOT enables diamine N-acetyltransferase activity	IDA IDA: Inferred from direct assay	15283699	GOA
enables diamine N-acetyltransferase activity	IDA IDA: Inferred from direct assay	12803540	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nor-spermidine metabolic process	IDA IDA: Inferred from direct assay	12803540	GOA
NOT involved in polyamine biosynthetic process	IDA IDA: Inferred from direct assay	15283699	GOA
involved in putrescine acetylation	IDA IDA: Inferred from direct assay	12803540	GOA
NOT involved in spermidine acetylation	IDA IDA: Inferred from direct assay	15283699	GOA
involved in spermidine acetylation	IDA IDA: Inferred from direct assay	12803540	GOA
involved in spermine acetylation	IDA IDA: Inferred from direct assay	12803540	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAT2 Protein Structure

Acetyltransf_1

0
100
170 a.a.

Protein Preferred Names

Protein Names

thialysine N-epsilon-acetyltransferase

diamine N-acetyltransferase 2

SAT2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SAT2	Q96F10	SAT1	Homo sapiens	P21673	Y2H Array	32296183
Intra	SAT2	Q96F10	SAT1	Homo sapiens	P21673	Anti Tag CoIP	33961781
Intra	SAT2	Q96F10	SAT1	Homo sapiens	P21673	Y2H Prey Pooling	32296183
Intra	SAT2	Q96F10	SAT2	Homo sapiens	Q96F10	Y2H Array	31515488
Intra	SAT2	Q96F10	POTEF	Homo sapiens	A5A3E0	Anti Tag CoIP	33961781
Intra	SAT2	Q96F10	PANK2	Homo sapiens	Q9BZ23	Anti Tag CoIP	33961781
Intra	SAT2	Q96F10	SAT2	Homo sapiens	Q96F10	Validated Y2H	32296183
Intra	SAT2	Q96F10	PANK2	Homo sapiens	Q9BZ23-3	Anti Tag CoIP	28514442
Intra	SAT2	Q96F10	SAT2	Homo sapiens	Q96F10	Y2H Array	32296183
Intra	SAT2	Q96F10	RYBP	Homo sapiens	Q8N488	TAP	24981860
Intra	SAT2	Q96F10	C1QBP	Homo sapiens	Q07021	Crosslink	30021884
Intra	SAT2	Q96F10	SAT2	Homo sapiens	Q96F10	Y2H Array	25416956
Intra	SAT2	Q96F10	H1-2	Homo sapiens	P16403	TAP	24981860
Intra	SAT2	Q96F10	NDUFA10	Homo sapiens	O95299	Crosslink	30021884
Intra	SAT2	Q96F10	SMR3B	Homo sapiens	P02814	TAP	24981860
Intra	SAT2	Q96F10	SAT2	Homo sapiens	Q96F10	Y2H Prey Pooling	32296183
Intra	SAT2	Q96F10	SMC1A	Homo sapiens	Q14683	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12456	SAT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SAT2	VGNC	VGNC:99444
Macaca mulatta	SAT2	VGNC	VGNC:77086
Bos taurus	SAT2	VGNC	VGNC:34297
Canis familiaris	SAT2	VGNC	VGNC:45874
Mus musculus	SAT2	MGD	MGI:1916465
Rattus norvegicus	SAT2	RGD	RGD:1307869
Others	SAT2	NCBI

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