H1-2 - H1.2 linker histone, cluster member Gene

Homo sapiens

Also known as H1C; H1.2; H1F2; H1s-1; HIST1H1C

Gene ID: 3006 | Gene type: protein coding

About H1-2

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,055,740-26,056,470 (from NCBI)

This gene has 1 transcript (splice variant), 81 orthologues and 9 paralogues.

Summary

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

H1-2 Products(1)

mRNA	Protein	Name
NM_005319.4	NP_005310.1	histone H1.2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	15911621	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22720776	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in euchromatin	IDA IDA: Inferred from direct assay	15911621	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21383955	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H1-2 Protein Structure

Linker_histone

0
100
200
213 a.a.

Protein Preferred Names

Protein Names

histone H1.2

H1 histone family, member 2

Related Diseases

Diseases

Alias

Supranuclear Palsy, Progressive, 1

Progressive Supranuclear Palsy	Steele-Richardson-Olszewski Syndrome
Supranuclear Palsy, Progressive	Progressive Supranuclear Ophthalmoplegia
Psp	PSNP1
Familial Progressive Supranuclear Palsy	Richardson'S Syndrome
Psp Syndrome	Progressive Supranuclear Palsy 1
Supranuclear Palsy Progressive	Ophthalmoplegia, Supranuclear, Progressive
Steele-Richardson-Olszewksi Syndrome

Pick Disease Of Brain

Pick Disease	Pick'S Disease
Pick Disease Of The Brain	Lobar Atrophy Of Brain
Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions	Behavioral Variant Of Frontotemporal Dementia
Dementia In Pick'S Disease	Lobar Atrophy Of The Brain
Bvftd	Bv-Ftd
PIDB	Picks Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109582	ADT-OH	Inducer	99.06%	Unkown
HY-W027592	1H-1,2,4-Triazol-3-amine		99.96%	Unkown
HY-23033	Tempone-H		99.08%	Unkown
HY-157334	DEG-77		98.31%	Unkown
HY-W012383	1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone		99.80%	Unkown
HY-103149	SB-216641A	Antagonist	≥98.0%	Unkown
HY-W007685	Methyl 1H-1,2,4-triazole-5-carboxylate		/	Unkown
HY-W012991	3-Mercapto-1,2,4-triazole		99.78%	Unkown
HY-W113615	4-Phenyl-1H-1,2,3-triazole	Inhibitor	≥98.0%	Unkown
HY-W098127S	Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate-d2		/	Unkown
HY-14988	I-A09	Inhibitor	/	Unkown
HY-149975	AMPA receptor modulator-4	Activator	/	Unkown
HY-N10765	Salvinolone	Inhibitor	/	Unkown
HY-RS05947	H1-2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W016149	4,5-Dichloro-3H-1,2-dithiol-3-one	Inhibitor	/	Unkown
HY-W110148S	Amitrole-13C,15N2		/	Unkown
HY-W329835S	2-((1H-1,2,4-Triazol-1-yl)methyl)-4-(4-chlorophenyl)-2-phenylbutanenitrile-d5		/	Unkown
HY-W700970	Methyl 1-β-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxylate		/	Unkown
HY-121366	Kadethrin	Inhibitor	/	Unkown
HY-123437	WAY-120744		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	H1-2	VGNC	VGNC:109667
Rattus norvegicus	H1-2	RGD	RGD:1587893
Bos taurus	H1-2	VGNC	VGNC:83558
Mus musculus	H1-2	MGD	MGI:1931526

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