ELOC - elongin C Gene

Homo sapiens

Also known as SIII; TCEB1

Gene ID: 6921 | Gene type: protein coding

About ELOC

Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:73,945,119-73,972,287 (from NCBI)

This gene has 15 transcripts (splice variants) and 246 orthologues. Ubiquitous expression in testis (RPKM 15.6), brain (RPKM 14.4) and 25 other tissues.

Summary

This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

ELOC Products(9)

mRNA	Protein	Name
NM_001204857.2	NP_001191786.1	elongin-C isoform a
NM_001204858.2	NP_001191787.1	elongin-C isoform a
NM_001204859.2	NP_001191788.1	elongin-C isoform a
NM_001204860.2	NP_001191789.1	elongin-C isoform a
NM_001204861.2	NP_001191790.1	elongin-C isoform a
NM_001204862.2	NP_001191791.1	elongin-C isoform a
NM_001204863.2	NP_001191792.1	elongin-C isoform b
NM_001204864.2	NP_001191793.1	elongin-C isoform b
NM_005648.4	NP_005639.1	elongin-C isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10205047	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	7660122	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	30166453	GOA
involved in target-directed miRNA degradation	IMP IMP: Inferred from mutant phenotype	33184237	GOA
involved in transcription initiation at RNA polymerase II promoter	IDA IDA: Inferred from direct assay	7660122	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul5-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	21980433	GOA
part of elongin complex	IDA IDA: Inferred from direct assay	7660122	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELOC Protein Structure

Skp1_POZ

0
100
112 a.a.

Protein Preferred Names

Protein Names

elongin-C

RNA polymerase II transcription factor SIII subunit C

ELOC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ELOC	Q15369	METTL21C	Homo sapiens	Q5VZV1	Validated Y2H	25416956
Intra	ELOC	Q15369	METTL21C	Homo sapiens	Q5VZV1	Validated Y2H	32296183
Intra	ELOC	Q15369	METTL21C	Homo sapiens	Q5VZV1	Y2H Array	32296183
Intra	ELOC	Q15369	METTL21C	Homo sapiens	Q5VZV1	Y2H Prey Pooling	25416956
Intra	ELOC	Q15369	METTL21C	Homo sapiens	Q5VZV1	Y2H Prey Pooling	32296183
Intra	ELOC	Q15369	METTL21C	Homo sapiens	Q5VZV1	Y2H Array	31515488
Cross	ELOC	Q15369	ORF10	SARS-CoV-2	A0A663DJA2	Y2H Array	36217030
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Validated Y2H	32296183
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Y2H Array	25416956
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Y2H Array	20211142
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Y2H Array	32296183
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Y2H	21516116
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Y2H Pooling	16189514
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Y2H Prey Pooling	25416956
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Validated Y2H	25416956
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Y2H Prey Pooling	32296183
Intra	ELOC	Q15369	PRAME	Homo sapiens	P78395	Y2H	23460923
Intra	ELOC	Q15369	PRAME	Homo sapiens	P78395	Confocal	23460923
Intra	ELOC	Q15369	MED8	Homo sapiens	Q96G25	Y2H	12149480
Intra	ELOC	Q15369	CUL2	Homo sapiens	Q13617	Pull Down	17183367
Intra	ELOC	Q15369	SOCS2	Homo sapiens	O14508	Y2H Array	16643902
Intra	ELOC	Q15369	ASB9	Homo sapiens	Q96DX5	Y2H Array	20211142
Intra	ELOC	Q15369	SOCS1	Homo sapiens	O15524	Pull Down	17183367
Cross	ELOC	Q15369	vif	Human immunodeficiency virus	P12504	Pull Down	22190034

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma	Hereditary Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma, Sporadic	Papillary Renal Cell Adenocarcinoma
RCCP	RCCP1
Renal Cell Carcinoma, Papillary	Renal Cell Carcinoma, Papillary, 1, Familial And Somatic
Chromophil Carcinoma Of Kidney	Papillary Kidney Carcinoma
Sporadic Papillary Renal Cell Carcinoma	Chromophil Renal Cell Carcinoma
Papillary Renal Carcinoma, Malignant -	Papillary Renal Cell Carcinoma, Bilateral -
Papillary Renal Cell Carcinoma, Familial -	Papillary Renal Cell Carcinoma, Multiple -
Papillary Renal Cell Carcinoma, Sporadic -	Renal Adenocarcinoma
Chromophil Rcc	Hprcc
Renal Cell Carcinoma Papillary	Chromophilic Renal Cell Carcinoma
Prcc	Carcinoma, Renal Cell, Papillary, Type 1
Type 1 Papillary Renal Cell Carcinoma	Renal Cell Carcinoma
Hereditary Papillary Renal Carcinoma

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Retinal Hemangioblastoma

Capillary Hemangioma Of Retina

Molluscum Contagiosum

Water Warts

Molluscum Verrucosum

Central Nervous System Hemangioma

Hemangioma Of Cns

Hemangioma Of The Central Nervous System

Erythrocytosis, Familial, 4

ECYT4	Familial Erythrocytosis 4
Erythrocytosis, Familial, Type 4

Familial Renal Papillary Carcinoma

Hereditary Papillary Renal Carcinoma

Papillary Renal Cancer Hereditary

Polycythemia

Erythrocythemia	Polycythemia Vera
Polycythaemia Due To High Altitude

Leiomyoma Cutis

Cutaneous Leiomyoma

Leiomyoma Of The Skin

Dermis Tumor

Dermis Tumour	Neoplasm Of Dermis
Tumor Of Dermis	Tumour Of Dermis

Erythrocytosis, Familial, 2

Chuvash Polycythemia	ECYT2
Familial Erythrocytosis 2	Autosomal Recessive Benign Erythrocytosis
Polycythemia, Vhl-Dependent	Chuvash Erythromatosis
Chuvash Type Polycythemia	Chuvash Erythrocytosis
Von Hippel-Lindau-Dependent Polycythemia	Polycythemia Chuvash Type
Vhl-Dependent Polycythemia	Erythrocytosis, Familial, Type 2

Inhibited Male Orgasm

Male Orgasmic Disorder

Psychosexual Dysfunction With Male Orgasmic Disorder

Primary Polycythemia

Familial Erythrocytosis	Familiar Polycythemia
Benign Familial Polycythemia	Congenital Erythrocytosis
Familial Polycythemia	Hereditary Erythrocytosis
Primary Familial Polycythemia	Erythrocytosis, Familial
Polycythemia Vera	Primary Familial Polycythaemia
Primary Inherited Polycythaemia

Hereditary Renal Cell Carcinoma

Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease	Vhl
Vhl Syndrome	VHLS
Von Hippel-Lindau Syndrome, Modifier Of	Hippel Lindau Syndrome
Angiomatosis Retinae	Cerebelloretinal Angiomatosis, Familial
Hippel-Lindau Disease	Familial Cerebelloretinal Angiomatosis
Lindau Disease	VHLD

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Cardiovascular Organ Benign Neoplasm

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04319	ELOC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ELOC	RGD	RGD:620658
Macaca mulatta	ELOC	VGNC	VGNC:82139
Mus musculus	ELOC	MGD	MGI:1915173
Bos taurus	ELOC	VGNC	VGNC:28445
Canis familiaris	ELOC	VGNC	VGNC:40317
Others	ELOC	NCBI

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