ELOB - elongin B Gene

Homo sapiens

Also known as SIII; TCEB2

Gene ID: 6923 | Gene type: protein coding

About ELOB

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,771,414-2,777,280 (from NCBI)

This gene has 8 transcripts (splice variants) and 281 orthologues. Ubiquitous expression in testis (RPKM 67.4), adrenal (RPKM 41.2) and 25 other tissues.

Summary

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]

ELOB Products(2)

mRNA	Protein	Name
NM_007108.4	NP_009039.1	elongin-B isoform a
NM_207013.3	NP_996896.1	elongin-B isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10205047	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	7660122	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	17636018	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in target-directed miRNA degradation	IMP IMP: Inferred from mutant phenotype	33184237	GOA
involved in transcription initiation at RNA polymerase II promoter	IDA IDA: Inferred from direct assay	7660122	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul2-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	17636018	GOA
part of Cul5-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	17636018	GOA
part of elongin complex	IDA IDA: Inferred from direct assay	7660122	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELOB Protein Structure

ubiquitin

0
100
118 a.a.

Protein Preferred Names

Protein Names

elongin-B

RNA polymerase II transcription factor SIII p18 subunit

ELOB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ELOB	Q15370	MRPL53	Homo sapiens	Q96EL3	Validated Y2H	32296183
Intra	ELOB	Q15370	ELOC	Homo sapiens	Q15369	Anti Tag CoIP	12149480
Intra	ELOB	Q15370	ELOC	Homo sapiens	Q15369	X-Ray Diffraction	12050673
Intra	ELOB	Q15370	ELOC	Homo sapiens	Q15369	Y2H Array	25416956
Intra	ELOB	Q15370	ELOC	Homo sapiens	Q15369	X-Ray Diffraction	10205047
Intra	ELOB	Q15370	ELOC	Homo sapiens	Q15369	X-Ray Diffraction	12004076
Intra	ELOB	Q15370	ELOC	Homo sapiens	Q15369	Y2H Prey Pooling	25416956
Intra	ELOB	Q15370	ELOC	Homo sapiens	Q15369	ITC	12004076
Intra	ELOB	Q15370	MED8	Homo sapiens	Q96G25	Anti Tag CoIP	12149480
Intra	ELOB	Q15370	MED8	Homo sapiens	Q96G25	Y2H	12149480
Cross	ELOB	Q15370	vif	Human immunodeficiency virus	P12504	Pull Down	22190034

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease	Vhl
Vhl Syndrome	VHLS
Von Hippel-Lindau Syndrome, Modifier Of	Hippel Lindau Syndrome
Angiomatosis Retinae	Cerebelloretinal Angiomatosis, Familial
Hippel-Lindau Disease	Familial Cerebelloretinal Angiomatosis
Lindau Disease	VHLD

Molluscum Contagiosum

Water Warts

Molluscum Verrucosum

Retinal Hemangioblastoma

Capillary Hemangioma Of Retina

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Erythrocytosis, Familial, 4

ECYT4	Familial Erythrocytosis 4
Erythrocytosis, Familial, Type 4

Familial Renal Papillary Carcinoma

Hereditary Papillary Renal Carcinoma

Papillary Renal Cancer Hereditary

Primary Polycythemia

Familial Erythrocytosis	Familiar Polycythemia
Benign Familial Polycythemia	Congenital Erythrocytosis
Familial Polycythemia	Hereditary Erythrocytosis
Primary Familial Polycythemia	Erythrocytosis, Familial
Polycythemia Vera	Primary Familial Polycythaemia
Primary Inherited Polycythaemia

Erythrocytosis, Familial, 2

Chuvash Polycythemia	ECYT2
Familial Erythrocytosis 2	Autosomal Recessive Benign Erythrocytosis
Polycythemia, Vhl-Dependent	Chuvash Erythromatosis
Chuvash Type Polycythemia	Chuvash Erythrocytosis
Von Hippel-Lindau-Dependent Polycythemia	Polycythemia Chuvash Type
Vhl-Dependent Polycythemia	Erythrocytosis, Familial, Type 2

Kidney Cancer

Renal Cancer	Renal Carcinoma
Kidney Neoplasm	Malignant Neoplasm Of Kidney Except Pelvis
Malignant Tumour Of Kidney	Kidney Neoplasms
Cancer, Kidney	Cancer, Renal
Malignant Neoplasm Of Kidney	Renal Cell Carcinoma

Pheochromocytoma

Pheochromocytoma, Susceptibility To	Phaeochromocytoma
Adrenal Gland Chromaffin Paraganglioma	Adrenal Gland Chromaffinoma
Adrenal Gland Paraganglioma	Adrenal Gland Pheochromocytoma
Chromaffin Paraganglioma Of The Adrenal Gland	Intraadrenal Paraganglioma
PCC	Chromaffin Cell Tumor
Medullary Chromaffinoma	Medullary Paraganglioma
Pheochromoblastoma	Pheochromocytomas
Chromaffin Cell Neoplasm	Pheochromocytoma, Malignant

Hereditary Renal Cell Carcinoma

Cardiovascular Organ Benign Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04318	ELOB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ELOB	RGD	RGD:621200
Canis familiaris	ELOB	VGNC	VGNC:40316
Mus musculus	ELOB	MGD	MGI:1914923
Felis catus	ELOB	VGNC	VGNC:80570
Others	ELOB	NCBI

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