MTFR2 - mitochondrial fission regulator 2 Gene

Homo sapiens

Also known as DUFD1; FAM54A

Gene ID: 113115 | Gene type: protein coding

About MTFR2

This gene has 7 transcripts (splice variants), 190 orthologues and 2 paralogues. Biased expression in testis (RPKM 2.0), bone marrow (RPKM 1.8) and 12 other tissues.

Summary

Predicted to be involved in aerobic respiration and mitochondrial fission. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

MTFR2 Products(3)

mRNA	Protein	Name
NM_001099286.3	NP_001092756.1	mitochondrial fission regulator 2 isoform a
NM_001318738.2	NP_001305667.1	mitochondrial fission regulator 2 isoform b
NM_138419.5	NP_612428.2	mitochondrial fission regulator 2 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTFR2 Protein Structure

Mito_fiss_reg

0
100
200
300
385 a.a.

Protein Preferred Names

Protein Names

mitochondrial fission regulator 2

DUF729 domain-containing protein 1

MTFR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MTFR2	Q6P444	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Intra	MTFR2	Q6P444	ALAS1	Homo sapiens	P13196	Y2H Prey Pooling	25416956
Intra	MTFR2	Q6P444	ALAS1	Homo sapiens	P13196	Validated Y2H	25416956
Intra	MTFR2	Q6P444	ALAS1	Homo sapiens	P13196	Y2H Array	25416956
Intra	MTFR2	Q6P444	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	MTFR2	Q6P444	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	25416956
Intra	MTFR2	Q6P444	TRIM23	Homo sapiens	P36406	Validated Y2H	25416956
Intra	MTFR2	Q6P444	MAGEA12	Homo sapiens	P43365	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Suppurative Periapical Periodontitis

Periapical Abscess	Apical Abscess
Suppurative Apical Periodontitis	Dentoalveolar Abscess
Dental Abscess With Sinus	Dentoalveolar Abscess With Sinus
Dental Sinus	Periapical Abscess Fistula
Apical Tooth Abscess	Apex Abscess
Dental Abscess Nos	Infection Of Tooth Nos
Abscess Of Tooth	Dental Infection Nos

Lung Acinar Adenocarcinoma

Acinar Adenocarcinoma Of The Lung

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08771	MTFR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MTFR2	VGNC	VGNC:82491
Macaca mulatta	MTFR2	VGNC	VGNC:74999
Mus musculus	MTFR2	MGD	MGI:1919054
Bos taurus	MTFR2	VGNC	VGNC:31728
Rattus norvegicus	MTFR2	RGD	RGD:6494892
Canis familiaris	MTFR2	VGNC	VGNC:43470

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