TUSC2 - tumor suppressor 2, mitochondrial calcium regulator Gene

Homo sapiens

Also known as PAP; FUS1; PDAP2; C3orf11

Gene ID: 11334 | Gene type: protein coding

About TUSC2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,324,909-50,328,223 (from NCBI)

This gene has 6 transcripts (splice variants) and 285 orthologues. Ubiquitous expression in brain (RPKM 15.7), kidney (RPKM 12.1) and 25 other tissues.

Summary

This gene is a highly conserved lung Cancer candidate gene. No other information about this gene is currently available. [provided by RefSeq, Jul 2008]

TUSC2 Products(1)

mRNA	Protein	Name
NM_007275.3	NP_009206.1	tumor suppressor candidate 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TUSC2 Protein Structure

TUSC2

0
100
110 a.a.

Protein Preferred Names

Protein Names

tumor suppressor candidate 2

PDGFA-associated protein 2

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15274	TUSC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TUSC2	MGD	MGI:1931086
Rattus norvegicus	TUSC2	RGD	RGD:1561664
Macaca mulatta	TUSC2	VGNC	VGNC:110321
Bos taurus	TUSC2	VGNC	VGNC:53155
Felis catus	TUSC2	VGNC	VGNC:97674

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