AKR7A2 - aldo-keto reductase family 7 member A2 Gene

Homo sapiens

Also known as AFAR; AKR7; AFAR1; AFB1-AR1

Gene ID: 8574 | Gene type: protein coding

About AKR7A2

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,302,708-19,312,146 (from NCBI)

This gene has 5 transcripts (splice variants), 249 orthologues and 16 paralogues. Ubiquitous expression in kidney (RPKM 26.6), duodenum (RPKM 20.0) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication Enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

AKR7A2 Products(2)

mRNA	Protein	Name
NM_001320979.1	NP_001307908.1	aflatoxin B1 aldehyde reductase member 2 isoform 2
NM_003689.4	NP_003680.2	aflatoxin B1 aldehyde reductase member 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables phenanthrene-9,10-epoxide hydrolase activity	IDA IDA: Inferred from direct assay	20837989	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in daunorubicin metabolic process	IMP IMP: Inferred from mutant phenotype	20837989	GOA
involved in doxorubicin metabolic process	IMP IMP: Inferred from mutant phenotype	20837989	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKR7A2 Protein Structure

Aldo_ket_red

0
100
200
300
359 a.a.

Protein Preferred Names

Protein Names

aflatoxin B1 aldehyde reductase member 2

AFB1 aldehyde reductase 1

AKR7A2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AKR7A2	O43488	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	AKR7A2	O43488	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	AKR7A2	O43488	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	AKR7A2	O43488	ZBTB1	Homo sapiens	Q9Y2K1	Y2H Prey Pooling	32296183
Intra	AKR7A2	O43488	ZBTB1	Homo sapiens	Q9Y2K1	Y2H Array	32296183
Intra	AKR7A2	O43488	ZBTB1	Homo sapiens	Q9Y2K1	Validated Y2H	32296183
Intra	AKR7A2	O43488	AKR7A3	Homo sapiens	O95154	Anti Tag CoIP	33961781
Intra	AKR7A2	O43488	AKR7A3	Homo sapiens	O95154	Validated Y2H	32296183
Intra	AKR7A2	O43488	AKR7A3	Homo sapiens	O95154	Y2H Array	32296183
Intra	AKR7A2	O43488	AKR7A3	Homo sapiens	O95154	Y2H Prey Pooling	32296183
Intra	AKR7A2	O43488	AKR7A3	Homo sapiens	O95154	Y2H Pooling	16189514
Intra	AKR7A2	O43488	ATXN3	Homo sapiens	P54252	Y2H Array	32814053
Intra	AKR7A2	O43488	ATXN3	Homo sapiens	P54252	Validated Y2H	32814053
Intra	AKR7A2	O43488	ATXN3	Homo sapiens	P54252	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Gamma-Amino Butyric Acid Metabolism Disorder

Disorder Of Gamma-Aminobutyric Acid Metabolism	Disorder Of Gaba Metabolism
Disorders Of Gaba - [Gamma Aminobutyric Acid] Metabolism

Succinic Semialdehyde Dehydrogenase Deficiency

4-Hydroxybutyric Aciduria	Ssadh Deficiency
Gamma-Hydroxybutyric Aciduria	Gaba Metabolic Defect
SSADHD	Ssadh
Succinate-Semialdehyde Dehydrogenase Deficiency	Gamma-Hydroxybutyricaciduria
4-Hydroxybutyricaciduria	Gamma-Hydroxybutyric Acidemia
Succinate Semialdehyde Dehydrogenase Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00540	AKR7A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AKR7A2	RGD	RGD:620311
Mus musculus	AKR7A2	MGD	MGI:107796

Name
Email *

	Sorry, but the email address you supplied was invalid.