2. Gene
  3. TMEM123 - transmembrane protein 123 Gene

TMEM123 - transmembrane protein 123 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as KCT3; PORMIN; PORIMIN

Gene ID: 114908 | Gene type: protein coding

About TMEM123

Cytogenetic location: 11q22.2 Genomic coordinates (GRCh38): 11:102,396,332-102,452,765 (from NCBI)

This gene has 8 transcripts (splice variants), 117 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 170.2), endometrium (RPKM 103.2) and 25 other tissues.

Summary

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from Apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]

TMEM123 Products(1)

mRNA Protein Name
NM_052932.3 NP_443164.2 porimin precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence Reference Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9600958 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

porimin

KCT-3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14657 TMEM123 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TMEM123 VGNC VGNC:103651
Rattus norvegicus TMEM123 RGD RGD:1305625
Macaca mulatta TMEM123 VGNC VGNC:101409
Felis catus TMEM123 VGNC VGNC:104336
Mus musculus TMEM123 MGD MGI:1919179