2. Gene
  3. TMEM123 - transmembrane protein 123 Gene

TMEM123 - transmembrane protein 123 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as KCT3; PORMIN; PORIMIN

Gene ID: 114908 | Gene type: protein coding

About TMEM123

Cytogenetic location: 11q22.2 Genomic coordinates (GRCh38): 11:102,396,332-102,452,765 (from NCBI)

This gene has 8 transcripts (splice variants), 117 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 170.2), endometrium (RPKM 103.2) and 25 other tissues.

Summary

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from Apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]

TMEM123 Products(1)

mRNA Protein Name
NM_052932.3 NP_443164.2 porimin precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence Reference Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9600958 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

porimin

KCT-3

TMEM123 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TMEM123 Q8N131 MAGEA11 Homo sapiens P43364-2
Y2H Array
25416956
Intra
TMEM123 Q8N131 MAGEA11 Homo sapiens P43364-2
Validated Y2H
25416956
Intra
TMEM123 Q8N131 ISY1 Homo sapiens Q9ULR0
Y2H Pooling
32814053
Intra
TMEM123 Q8N131 ISY1 Homo sapiens Q9ULR0
Validated Y2H
32814053
Intra
TMEM123 Q8N131 ISY1 Homo sapiens Q9ULR0
Y2H Array
32814053
Intra
TMEM123 Q8N131 WDFY1 Homo sapiens Q8IWB7
Anti Tag CoIP
33961781
Intra
TMEM123 Q8N131 WDFY1 Homo sapiens Q8IWB7
Anti Tag CoIP
28514442
Intra
TMEM123 Q8N131 MAGEA11 Homo sapiens P43364
Y2H Prey Pooling
32296183
Intra
TMEM123 Q8N131 MAGEA11 Homo sapiens P43364
Y2H Array
32296183
Intra
TMEM123 Q8N131 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
TMEM123 Q8N131 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
TMEM123 Q8N131 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
TMEM123 Q8N131 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
TMEM123 Q8N131 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
TMEM123 Q8N131 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14657 TMEM123 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TMEM123 VGNC VGNC:103651
Rattus norvegicus TMEM123 RGD RGD:1305625
Macaca mulatta TMEM123 VGNC VGNC:101409
Felis catus TMEM123 VGNC VGNC:104336
Mus musculus TMEM123 MGD MGI:1919179