Nr0b1 - nuclear receptor subfamily 0, group B, member 1 Gene

Mus musculus

Also known as AHX; Ahc; Ahch; Dax1; DAX-1

Gene ID: 11614 | Gene type: protein coding

About Nr0b1

Summary

This gene encodes an orphan nuclear receptor protein that plays a key role in differentiation of the gonads. This protein regulates steroidogenic factor 1 (Sf-1) in a dose-dependent manner, sometimes functioning as a repressor of SF-1 target genes, and sometimes functioning as a co-activator. Overexpression of this gene can cause feminization of the XY male gonads. This gene is also involved in the maintenance of embryonic stem cell pluripotancy. Mutations in the related gene in human cause congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, May 2015]

Nr0b1 Products(1)

mRNA	Protein	Name
NM_007430.5	NP_031456.1	nuclear receptor subfamily 0 group B member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	10848616	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15155786	MGI
NOT enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	27601327	MGI
enables transcription corepressor activity	IGI IGI: Inferred from genetic interaction	15155786	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	23508100	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Leydig cell differentiation	IGI IGI: Inferred from genetic interaction	15829514	MGI
acts upstream of or within Leydig cell differentiation	IMP IMP: Inferred from mutant phenotype	11564714	MGI
acts upstream of or within Sertoli cell differentiation	IGI IGI: Inferred from genetic interaction	15829514	MGI
acts upstream of or within Sertoli cell differentiation	IMP IMP: Inferred from mutant phenotype	11564714	MGI
acts upstream of or within adrenal gland development	IGI IGI: Inferred from genetic interaction	11796523	MGI
acts upstream of or within endodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	16466956	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	12679814	MGI
acts upstream of or within male sex determination	IGI IGI: Inferred from genetic interaction	15944188	MGI
acts upstream of or within male sex determination	IMP IMP: Inferred from mutant phenotype	12679814	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15062575	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	23508100	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15155786	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15155786	MGI
acts upstream of or within response to immobilization stress	IMP IMP: Inferred from mutant phenotype	11796523	MGI
acts upstream of or within sex determination	IGI IGI: Inferred from genetic interaction	9486644	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	9843206	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12610109	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10848616	MGI
located in ribosome	IDA IDA: Inferred from direct assay	10848616	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear receptor subfamily 0 group B member 1

adrenal hypoplasia congenita-like protein	adrenal hypoplasia, congenital homolog
nuclear receptor DAX-1

Nr0b1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nr0b1	Q61066	Pou5f1	Mus musculus	P20263	Anti Tag CoIP	20362541
Intra	Nr0b1	Q61066	Pou5f1	Mus musculus	P20263	Pull Down	20362541
Intra	Nr0b1	Q61066	Pou5f1	Mus musculus	P20263	Anti Tag CoIP	17093407
Intra	Nr0b1	Q61066	Nanog	Mus musculus	Q80Z64	Anti Tag CoIP	17093407
Intra	Nr0b1	Q61066	Rif1	Mus musculus	Q6PR54	Anti Tag CoIP	20362541
Intra	Nr0b1	Q61066	Rif1	Mus musculus	Q6PR54	Anti Tag CoIP	17093407
Intra	Nr0b1	Q61066	Esrrb	Mus musculus	Q61539	Anti Tag CoIP	20362541
Intra	Nr0b1	Q61066	Esrrb	Mus musculus	Q61539	Pull Down	20362541

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122054A	BPK-29 hydrochloride	Inhibitor	98.28%	Unkown
HY-122054	BPK-29	Inhibitor	99.4%	Unkown
HY-RS09525	NR0B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr0b1	NCBI	NCBI:190

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