Nanog - Nanog homeobox Gene

Mus musculus

Also known as ENK; Stm1; ecat4; 2410002E02Rik

Gene ID: 71950 | Gene type: protein coding

About Nanog

Summary

The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Nanog Products(4)

mRNA	Protein	Name
NM_001289828.1	NP_001276757.1	homeobox protein NANOG isoform 2
NM_001289830.1	NP_001276759.1	homeobox protein NANOG isoform 3
NM_001289831.1	NP_001276760.1	homeobox protein NANOG isoform 3
NM_028016.3	NP_082292.1	homeobox protein NANOG isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12787504	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18957414	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	22988117	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	22988117	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21062744	MGI
enables RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	IDA IDA: Inferred from direct assay	23040477	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	18467660	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	18436640	MGI
enables lysine-acetylated histone binding	IDA IDA: Inferred from direct assay	23798425	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17093407	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18400104	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	20123909	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	18957414	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of BMP signaling pathway	IDA IDA: Inferred from direct assay	16801560	MGI
involved in cell dedifferentiation	IDA IDA: Inferred from direct assay	23040477	MGI
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	12787504	MGI
involved in embryonic pattern specification	IEP IEP: Inferred from expression pattern	15108323	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	17267691	MGI
involved in gonad development	IEP IEP: Inferred from expression pattern	15108323	MGI
acts upstream of mesodermal cell fate commitment	IDA IDA: Inferred from direct assay	16801560	MGI
acts upstream of mesodermal cell fate commitment	IGI IGI: Inferred from genetic interaction	16801560	MGI
acts upstream of or within mesodermal cell fate commitment	IGI IGI: Inferred from genetic interaction	16801560	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	16801560	MGI
acts upstream of or within negative regulation of cell fate commitment	IDA IDA: Inferred from direct assay	16801560	MGI
acts upstream of or within negative regulation of cell fate commitment	IGI IGI: Inferred from genetic interaction	16801560	MGI
acts upstream of or within negative regulation of stem cell differentiation	IDA IDA: Inferred from direct assay	17940068	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16801560	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21385842	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18957414	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20937355	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16259959	MGI
acts upstream of or within positive regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	16259959	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20937355	MGI
involved in regulation of stem cell division	IDA IDA: Inferred from direct assay	23040477	MGI
acts upstream of or within response to retinoic acid	IDA IDA: Inferred from direct assay	18400104	MGI
acts upstream of or within somatic stem cell population maintenance	IDA IDA: Inferred from direct assay	16801560	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	12787504	MGI
acts upstream of stem cell differentiation	IDA IDA: Inferred from direct assay	17940068	MGI
acts upstream of or within stem cell differentiation	IDA IDA: Inferred from direct assay	20123909	MGI
acts upstream of or within stem cell differentiation	IMP IMP: Inferred from mutant phenotype	16894029	MGI
acts upstream of or within stem cell division	IDA IDA: Inferred from direct assay	12787505	MGI
involved in stem cell population maintenance	IEP IEP: Inferred from expression pattern	15108323	MGI
acts upstream of or within stem cell population maintenance	IGI IGI: Inferred from genetic interaction	17938240	MGI
involved in stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	25825768	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in chromatin	IDA IDA: Inferred from direct assay	23798425	MGI
NOT located in condensed chromosome	IMP IMP: Inferred from mutant phenotype	27723719	MGI
located in nucleoplasm	IDA IDA: Inferred from direct assay	21076177	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	23798425	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15582778	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein NANOG

ES cell-associated protein 4	early embryo specific expression NK family
early embryo specific expression NK-type homeobox protein	homeobox transcription factor Nanog

Nanog Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nanog	Q80Z64	Pou5f1	Mus musculus	P20263	Anti Tag CoIP	17093407
Intra	Nanog	Q80Z64	Pou5f1	Mus musculus	P20263	Pull Down	17093407
Intra	Nanog	Q80Z64	Rif1	Mus musculus	Q6PR54	TAP	17093407
Intra	Nanog	Q80Z64	Rif1	Mus musculus	Q6PR54	Anti Bait CoIP	17093407
Intra	Nanog	Q80Z64	Rif1	Mus musculus	Q6PR54	Pull Down	17093407
Intra	Nanog	Q80Z64	Nr0b1	Mus musculus	Q61066	Pull Down	17093407
Intra	Nanog	Q80Z64	Nr0b1	Mus musculus	Q61066	Anti Tag CoIP	23892456
Intra	Nanog	Q80Z64	Nr0b1	Mus musculus	Q61066	TAP	17093407
Intra	Nanog	Q80Z64	Nr0b1	Mus musculus	Q61066	Anti Tag CoIP	17093407
Intra	Nanog	Q80Z64	Slc8a1	Mus musculus	P70414	Pull Down	17093407
Intra	Nanog	Q80Z64	Slc8a1	Mus musculus	P70414	Anti Tag CoIP	17093407
Intra	Nanog	Q80Z64	Slc8a1	Mus musculus	P70414	TAP	17093407
Intra	Nanog	Q80Z64	Znf281	Mus musculus	Q99LI5	Pull Down	17093407
Intra	Nanog	Q80Z64	Znf281	Mus musculus	Q99LI5	Anti Tag CoIP	17093407
Intra	Nanog	Q80Z64	Znf281	Mus musculus	Q99LI5	Anti Tag CoIP	23892456
Intra	Nanog	Q80Z64	Sox2	Mus musculus	P48432	Pull Down	23892456
Intra	Nanog	Q80Z64	Sox2	Mus musculus	P48432	Anti Tag CoIP	23892456
Intra	Nanog	Q80Z64	Pin1	Mus musculus	Q9QUR7	Anti Bait CoIP	20622153

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17602	Amcasertib	Inhibitor	98.07%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12303	OAC1	Activator	99.56%	Unkown
HY-18772	O4I2	Activator	99.30%	Unkown
HY-119672	Oct4 inducer-1	Activator	98.27%	Unkown
HY-RS09019	NANOG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-119666	Rooperol	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nanog	NCBI	NCBI:79923

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