2. Gene
  3. Aldh3a1 - aldehyde dehydrogenase family 3, subfamily A1 Gene

Aldh3a1 - aldehyde dehydrogenase family 3, subfamily A1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ahd4; Aldh; Ahd-4; Aldh3

Gene ID: 11670 | Gene type: protein coding

About Aldh3a1

Chromosome 11: 61,098,363-61,109,247 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 370 orthologues, 19 paralogues and is associated with 1 phenotype. Biased expression in bladder adult (RPKM 55.3), stomach adult (RPKM 53.6) and 1 other tissue.

Summary

Enables 3-chloroallyl aldehyde dehydrogenase activity and aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in several processes, including response to cAMP; response to glucocorticoid; and response to hypoxia. Located in cytoplasm. Is integral component of membrane. Is expressed in several structures, including alimentary system; decidua; early conceptus; gonad; and liver. Human ortholog(s) of this gene implicated in arteriosclerosis. Orthologous to human ALDH3A1 (aldehyde dehydrogenase 3 family member A1). [provided by Alliance of Genome Resources, Apr 2022]

Aldh3a1 Products(3)

mRNA Protein Name
NM_007436.2 NP_031462.2 aldehyde dehydrogenase, dimeric NADP-preferring isoform 1
NM_001112725.1 NP_001106196.1 aldehyde dehydrogenase, dimeric NADP-preferring isoform 1
NM_001331112.1 NP_001318041.1 aldehyde dehydrogenase, dimeric NADP-preferring isoform 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 3-chloroallyl aldehyde dehydrogenase activity IDA
IDA: Inferred from direct assay
742739 MGI
enables 3-chloroallyl aldehyde dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
11784860 MGI
enables aldehyde dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
25286108 MGI
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IDA
IDA: Inferred from direct assay
10376761 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25286108 MGI
located in membrane IDA
IDA: Inferred from direct assay
25286108 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aldh3a1 Protein Structure

ALDH_F3AB

ALDH_F3AB: cd07132 (4 - 446)

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  • 453 a.a.
Protein Preferred Names Protein Names

aldehyde dehydrogenase, dimeric NADP-preferring

alcohol dehydrogenase family 3, subfamily A1

aldehyde dehydrogenase 3, stomach cytosolic (class 3)

aldehyde dehydrogenase 4

aldehyde dehydrogenase family 3 member A1

dioxin-inducible aldehyde dehydrogenase 3

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0364A Dyclonine hydrochloride Inhibitor 99.86% Unkown
Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-123962 G6PD activator AG1 Activator 99.54% Unkown
HY-W017186 ALDH1A3-IN-3 Inhibitor 99.12% Unkown
HY-144670 ALDH3A1-IN-1 Inhibitor ≥95.0% Unkown
HY-146683 KS106 99.31% Unkown
HY-144669 ALDH1A3-IN-2 Inhibitor 99.28% Unkown
HY-146682 KS100 99.61% Unkown
HY-122577 EN40 Inhibitor 99.56% Unkown
HY-125085 ALDH3A1-IN-3 Inhibitor 99.30% Unkown
HY-144671 ALDH3A1-IN-2 Inhibitor / Unkown
HY-159111 KS124 / Unkown
HY-RS00571 ALDH3A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00572 Aldh3a1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00573 Aldh3a1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00575 ALDH3B1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aldh3a1 NCBI NCBI:218