ALDH3A1 - aldehyde dehydrogenase 3 family member A1 Gene

Homo sapiens

Also known as ALDH3; ALDHIII

Gene ID: 218 | Gene type: protein coding

About ALDH3A1

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,737,984-19,748,298 (from NCBI)

This gene has 17 transcripts (splice variants), 370 orthologues and 17 paralogues. Biased expression in esophagus (RPKM 74.7), stomach (RPKM 49.1) and 1 other tissue.

Summary

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The Enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

ALDH3A1 Products(6)

mRNA	Protein	Name
NM_001135167.1	NP_001128639.1	aldehyde dehydrogenase, dimeric NADP-preferring isoform 1
NM_001330150.2	NP_001317079.1	aldehyde dehydrogenase, dimeric NADP-preferring isoform 2
NM_001135168.1	NP_001128640.1	aldehyde dehydrogenase, dimeric NADP-preferring isoform 1
XM_011523731.3	XP_011522033.1	aldehyde dehydrogenase, dimeric NADP-preferring isoform X2
XM_047435595.1	XP_047291551.1	aldehyde dehydrogenase, dimeric NADP-preferring isoform X1
NM_000691.5	NP_000682.3	aldehyde dehydrogenase, dimeric NADP-preferring isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables alcohol dehydrogenase (NADP+) activity	IDA IDA: Inferred from direct assay	1737758	GOA
enables aldehyde dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	1737758	GOA
enables benzaldehyde dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	4015840	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular aldehyde metabolic process	IDA IDA: Inferred from direct assay	1737758	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALDH3A1 Protein Structure

Aldedh

0
100
200
300
400
453 a.a.

Protein Preferred Names

Protein Names

aldehyde dehydrogenase, dimeric NADP-preferring

aldehyde dehydrogenase isozyme 3	aldehyde dehydrogenase type III
stomach aldehyde dehydrogenase

ALDH3A1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ALDH3A1	P30838	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950
Intra	ALDH3A1	P30838	POT1	Homo sapiens	Q9NUX5	BiFC	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALDH3A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7477	ALDH3A1 Protein, Human (HEK293, His)	P30838 (M1-Q452)	≥95%
HY-P75568	ALDH3A1 Protein, Human (sf9, His)	AAH04370.1 (M1-H453)	≥95%

Related Diseases

Diseases

Alias

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Hyperprolinemia

Proline Oxidase Deficiency	Hyperprolinemia Type 1
Proline Hydrogenase Deficiency	Prolinemia
Pyrroline Carboxylate Dehydrogenase Deficiency	Pyrroline-5-Carboxylate Dehydrogenase Deficiency
Proline Dehydrogenase Deficiency	Hyperprolinemia Type 2

Sjogren-Larsson Syndrome

Sjögren-Larsson Syndrome	SLS
Faldh Deficiency	Fatty Aldehyde Dehydrogenase Deficiency
Fatty Acid Alcohol Oxidoreductase Deficiency	Ichthyosis, Spastic Neurologic Disorder, And Oligophrenia
Sjogren Larsson Syndrome	Fatty Alcohol:Nad+ Oxidoreductase Deficiency
Sjogren-Larsson'S Syndrome	Fadh Deficiency
Fao Deficiency	Congenital Icthyosis Mental Retardation Spasticity Syndrome
Ichthyosis Oligophrenia Syndrome	Sjoegren-Larsson Syndrome

Keratoconus

Kc	Conical Cornea
Noninflammatory Corneal Thining	Bulging Cornea
Cornea Conical	Acquired Conus Of Cornea

Smith-Magenis Syndrome

SMS	Chromosome 17p11.2 Deletion Syndrome
17p11.2 Microdeletion Syndrome	17p11.2 Monosomy
Chromosome 17p Deletion Syndrome	Del(17)
P11.2	17p- Syndrome
Deletion 17p Syndrome	Partial Monosomy 17p

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0364A	Dyclonine hydrochloride	Inhibitor	99.86%	Unkown

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123962	G6PD activator AG1	Activator	99.54%	Unkown
HY-W017186	ALDH1A3-IN-3	Inhibitor	99.12%	Unkown
HY-144670	ALDH3A1-IN-1	Inhibitor	≥95.0%	Unkown
HY-144669	ALDH1A3-IN-2	Inhibitor	99.28%	Unkown
HY-146683	KS106		99.31%	Unkown
HY-146682	KS100		99.61%	Unkown
HY-122577	EN40	Inhibitor	99.56%	Unkown
HY-125085	ALDH3A1-IN-3	Inhibitor	99.30%	Unkown
HY-144671	ALDH3A1-IN-2	Inhibitor	/	Unkown
HY-159111	KS124		/	Unkown
HY-RS00571	ALDH3A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00572	Aldh3a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00573	Aldh3a1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00575	ALDH3B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ALDH3A1	RGD	RGD:2088
Canis familiaris	ALDH3A1	VGNC	VGNC:37786
Macaca mulatta	ALDH3A1	VGNC	VGNC:69786
Mus musculus	ALDH3A1	MGD	MGI:1353451
Bos taurus	ALDH3A1	VGNC	VGNC:25813
Felis catus	ALDH3A1	VGNC	VGNC:59736
Others	ALDH3A1	NCBI

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