Sh3gl2 - SH3 domain containing GRB2 like 2, endophilin A1 Gene

Rattus norvegicus

Also known as Sh3p4; Sh3d2a

Gene ID: 116743 | Gene type: protein coding

About Sh3gl2

Summary

Enables several functions, including identical protein binding activity; protein C-terminus binding activity; and protein kinase binding activity. Involved in several processes, including lipid tube assembly; positive regulation of membrane tubulation; and vesicle scission. Located in several cellular components, including basal dendrite; neuronal cell body; and perinuclear region of cytoplasm. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and synaptic vesicle membrane. Biomarker of visual epilepsy. Orthologous to human SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1). [provided by Alliance of Genome Resources, Apr 2022]

Sh3gl2 Products(1)

mRNA	Protein	Name
NM_053935.1	NP_446387.1	endophilin-A1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	24568626	RGD
enables lipid binding	IDA IDA: Inferred from direct assay	11604418	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9238017	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11384986	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	22961472	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in lipid tube assembly	IDA IDA: Inferred from direct assay	20484046	RGD
involved in membrane bending	IMP IMP: Inferred from mutant phenotype	16763559	RGD
involved in membrane tubulation	IDA IDA: Inferred from direct assay	20484046	RGD
involved in membrane tubulation	IMP IMP: Inferred from mutant phenotype	11604418	RGD
involved in positive regulation of membrane tubulation	IMP IMP: Inferred from mutant phenotype	24778241	RGD
involved in regulation of clathrin-dependent endocytosis	IMP IMP: Inferred from mutant phenotype	15066995	RGD
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	22099461	RGD
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	22099461	RGD
involved in vesicle scission	IDA IDA: Inferred from direct assay	11604418	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	11518713	RGD
located in basal dendrite	IDA IDA: Inferred from direct assay	14751282	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17088211	RGD
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	11518713	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	14751282	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14751282	RGD
located in presynapse	IDA IDA: Inferred from direct assay	11518713	RGD
is active in synapse	IDA IDA: Inferred from direct assay	11518713	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	17088211	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

endophilin-A1

SH3 domain protein 2A	SH3 domain-containing GRB2-like 2
SH3 domain-containing GRB2-like protein 2	SH3-domain GRB2-like 2
endophilin-1

Sh3gl2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Sh3gl2	O35179	Synj1	Rattus norvegicus	Q62910	Pull Down	9238017
Intra	Sh3gl2	O35179	Synj1	Rattus norvegicus	Q62910	Far-WB	9238017
Intra	Sh3gl2	O35179	Dnm1	Rattus norvegicus	P21575	Anti Bait CoIP	17437541
Intra	Sh3gl2	O35179	Dnm1	Rattus norvegicus	P21575	Pull Down	16221862
Intra	Sh3gl2	O35179	Dnm1	Rattus norvegicus	P21575	Far-WB	9238017
Intra	Sh3gl2	O35179	Dnm1	Rattus norvegicus	P21575	Pull Down	9238017

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12837	SH3GL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sh3gl2	NCBI	NCBI:6456

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