Xiap - X-linked inhibitor of apoptosis Gene

Mus musculus

Also known as Aipa; Api3; IAP3; MIHA; Birc4; ILP-1; 1110015C02Rik

Gene ID: 11798 | Gene type: protein coding

About Xiap

Chromosome X: 41,148,556-41,198,533 forward strand.GRCm39:CM001013.3

This gene has 11 transcripts (splice variants), 217 orthologues, 10 paralogues and is associated with 15 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 7.1), bladder adult (RPKM 6.9) and 26 other tissues.

Summary

The protein encoded by this gene is a member of the inhibitor of Apoptosis (IAP) family of proteins. While first identified for its role in blocking Apoptosis, this protein modulates many Other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. This protein blocks Apoptosis by binding and inhibiting target caspases after they have been activated. Binding occurs to some, but not all, caspases. This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 Ligase domain. In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this gene is found on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Xiap Products(3)

mRNA	Protein	Name
NM_001301641.1	NP_001288570.1	E3 ubiquitin-protein ligase XIAP
NM_001301639.1	NP_001288568.1	E3 ubiquitin-protein ligase XIAP
NM_009688.3	NP_033818.2	E3 ubiquitin-protein ligase XIAP

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11604410	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within inhibition of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	14623868	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12153481	MGI
acts upstream of or within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	12011074	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	14623868	MGI
involved in regulation of apoptosis involved in tissue homeostasis	IMP IMP: Inferred from mutant phenotype	30389919	MGI
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	35263589	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15737931	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Xiap Protein Structure

BIR

UBA_BIRC4_8

RING-HC_BIRC4_8

0
100
200
300
400
496 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase XIAP

IAP homolog A	RING-type E3 ubiquitin transferase XIAP
X-linked IAP	baculoviral IAP repeat-containing protein 4
inhibitor of apoptosis protein 3

Xiap Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Xiap	Q60989	Htra2	Mus musculus	Q9JIY5	Anti Tag CoIP	11604410
Intra	Xiap	Q60989	Hccs	Mus musculus	P53702	Pull Down	16858406

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15454	Xevinapant	Antagonist	99.91%	Phase 3
HY-13208	Xevinapant hydrochloride	Antagonist	98.01%	Phase 3

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12600	AZD5582	Antagonist	98.75%	Unkown
HY-17473	Embelin	Antagonist	98.75%	Unkown
HY-110346	AZD5582 dihydrochloride	Antagonist	98.67%	Unkown
HY-151966	TD1092	Degrader	99.49%	Unkown
HY-125378	SBP-0636457	Antagonist	98.42%	Unkown
HY-102051	XIAP/cIAP1 antagonist-1	Inhibitor	/	Unkown
HY-100682	T-3256336	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Xiap	NCBI	NCBI:331

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