Bcl2l1 - BCL2-like 1 Gene

Mus musculus

Also known as BclX; Bcl2l; bcl-x; Bcl-XL; Bcl(X)L; bcl2-L-1

Gene ID: 12048 | Gene type: protein coding

About Bcl2l1

Chromosome 2: 152,622,588-152,673,648 reverse strand.GRCm39:CM000995.3

This gene has 9 transcripts (splice variants), 285 orthologues, 10 paralogues and is associated with 20 phenotypes. Ubiquitous expression in thymus adult (RPKM 18.5), liver E14.5 (RPKM 15.3) and 28 other tissues.

Summary

This gene encodes a member of the Bcl-2 Family of Apoptosis regulators. The encoded protein is localized to the inner and outer mitochondrial membranes and regulates the programmed cell death pathway during development and tissue homeostasis. This protein binds to voltage-dependent anion channels in the outer mitochondrial membrane to facilitate the uptake of calcium ions. Mice embryos lacking this gene survived for two weeks and exhibited cell death of immature hematopoietic cells and neurons. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jan 2014]

Bcl2l1 Products(5)

mRNA	Protein	Name
NM_001289717.1	NP_001276646.1	bcl-2-like protein 1 isoform a
NM_001289739.1	NP_001276668.1	bcl-2-like protein 1 isoform b
NM_001355053.1	NP_001341982.1	bcl-2-like protein 1 isoform a
NM_009743.5	NP_033873.3	bcl-2-like protein 1 isoform a
NM_001289716.1	NP_001276645.1	bcl-2-like protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7650488	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	10894153	MGI
acts upstream of or within apoptotic process in bone marrow cell	IMP IMP: Inferred from mutant phenotype	10618441	MGI
acts upstream of or within cellular response to alkaloid	IDA IDA: Inferred from direct assay	15231831	MGI
acts upstream of or within cellular response to amino acid stimulus	IMP IMP: Inferred from mutant phenotype	15231831	MGI
acts upstream of or within cellular response to gamma radiation	IMP IMP: Inferred from mutant phenotype	15231831	MGI
acts upstream of dendritic cell apoptotic process	IDA IDA: Inferred from direct assay	17267035	MGI
acts upstream of dendritic cell proliferation	IDA IDA: Inferred from direct assay	17267035	MGI
acts upstream of ectopic germ cell programmed cell death	IMP IMP: Inferred from mutant phenotype	10894153	MGI
acts upstream of or within epithelial cell proliferation	IDA IDA: Inferred from direct assay	9176392	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	12115603	MGI
acts upstream of or within fertilization	IGI IGI: Inferred from genetic interaction	10894153	MGI
acts upstream of or within germ cell development	IGI IGI: Inferred from genetic interaction	10894153	MGI
acts upstream of or within germ cell development	IMP IMP: Inferred from mutant phenotype	10894153	MGI
acts upstream of or within hepatocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	10618441	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	10618441	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	14517295	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	10894153	MGI
acts upstream of or within mitochondrion organization	IGI IGI: Inferred from genetic interaction	20671748	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	9867803	MGI
acts upstream of or within negative regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	8798452	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10894153	MGI
acts upstream of or within negative regulation of dendritic cell apoptotic process	IDA IDA: Inferred from direct assay	17267035	MGI
acts upstream of or within negative regulation of developmental process	IMP IMP: Inferred from mutant phenotype	10894153	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	7753802	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	9096145	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	11150333	MGI
acts upstream of or within negative regulation of reproductive process	IMP IMP: Inferred from mutant phenotype	10894153	MGI
acts upstream of neuron apoptotic process	IDA IDA: Inferred from direct assay	7753802	MGI
acts upstream of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	9096145	MGI
acts upstream of or within neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10618441	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	11150333	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	10618441	MGI
acts upstream of or within ovarian follicle development	IGI IGI: Inferred from genetic interaction	10894153	MGI
acts upstream of or within ovarian follicle development	IMP IMP: Inferred from mutant phenotype	10894153	MGI
acts upstream of or within positive regulation of mononuclear cell proliferation	IDA IDA: Inferred from direct assay	17267035	MGI
acts upstream of or within regulation of growth	IMP IMP: Inferred from mutant phenotype	10894153	MGI
acts upstream of or within release of cytochrome c from mitochondria	IGI IGI: Inferred from genetic interaction	17052454	MGI
acts upstream of or within response to cycloheximide	IDA IDA: Inferred from direct assay	9176392	MGI
acts upstream of or within response to radiation	IMP IMP: Inferred from mutant phenotype	14517295	MGI
acts upstream of or within response to virus	IDA IDA: Inferred from direct assay	15231831	MGI
acts upstream of or within spermatogenesis	IGI IGI: Inferred from genetic interaction	10894153	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	11980919	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	26582200	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	11146504	MGI
located in membrane	IDA IDA: Inferred from direct assay	26582200	MGI
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	11980919	MGI
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	23530063	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	7607090	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bcl2l1 Protein Structure

bcl-2

0
100
200
233 a.a.

Protein Preferred Names

Protein Names

bcl-2-like protein 1

B-cell leukemia/lymphoma x	anti-apoptosis regulatory protein
apoptosis regulator Bcl-X

Recombinant Bcl2l1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72846	Bcl-XL Protein, Mouse (His)	Q64373-1 (M1-R212)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Phase Phase 3 Phase 2
HY-10969	Obatoclax Mesylate	99.85%	Phase 3
HY-10969A	Obatoclax	≥99.0%	Phase 3
HY-15464A	(R)-(-)-Gossypol acetic acid	98.93%	Phase 2
HY-15464	(R)-(-)-Gossypol	98.82%	Phase 2

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect Inhibitor Pre-designed Sets	Purity	Rare Diseases Unkown
HY-125876	PROTAC Bcl2 degrader-1	Inhibitor	99.80%	Unkown
HY-132307	Mcl-1 inhibitor 6		98.40%	Unkown
HY-15191B	(S)-Sabutoclax	Inhibitor	98.03%	Unkown
HY-135273	A-1211212		/	Unkown
HY-RS01421	BCL2L1 Human Pre-designed siRNA Set A		/	Unkown
HY-114310	VDR agonist 1		/	Unkown
HY-19551	Apogossypolone		/	Unkown
HY-118925	Holothurin A	Inhibitor	/	Unkown
HY-123715	Anticancer agent 255		/	Unkown
HY-144428	Bcl-2/Mcl-1-IN-2	Inhibitor	/	Unkown
HY-144430	Bcl-2/Mcl-1-IN-1	Inhibitor	/	Unkown
HY-144431	Bcl-2/Mcl-1-IN-3	Inhibitor	/	Unkown
HY-147826	EGFR-IN-60		/	Unkown
HY-149436	CDK2/Bcl2-IN-1	Inhibitor	/	Unkown
HY-156877	Bcl-2-IN-16	Inhibitor	/	Unkown
HY-159513	Bcl-2/Mcl-1-IN-4	Inhibitor	/	Unkown
HY-161415	BCL-xL/BCL-2 ligand 1		/	Unkown
HY-169083	Bcl-2-IN-22	Inhibitor	/	Unkown
HY-N3828	epi-Eriocalyxin A		/	Unkown
HY-RS01418	BCL2A1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01419	Bcl2a1 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS01420	Bcl2a1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01422	Bcl2l1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01423	Bcl2l1 Rat Pre-designed siRNA Set A		/	Unkown
HY-12011A	(Rac)-HA14-1	Inhibitor	/	Unkown
HY-N8579	Eugenyl benzoate		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bcl2l1	NCBI	NCBI:598

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