Cd14 - CD14 antigen Gene

Mus musculus

Gene ID: 12475 | Gene type: protein coding

About Cd14

Summary

This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte/macrophage cells. This gene product acts as a co-receptor that binds several microbial and Fungal molecules, including lipopolysaccharides (LPS). This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex. The product of this gene is found in two forms, either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor. [provided by RefSeq, Jul 2014]

Cd14 Products(1)

mRNA	Protein	Name
NM_009841.4	NP_033971.1	monocyte differentiation antigen CD14 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	8612135	MGI
involved in positive regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	22078883	MGI
involved in positive regulation of lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24380872	MGI
involved in positive regulation of toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	24380872	MGI
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	8612135	MGI
involved in positive regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	22078883	MGI
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	24380872	MGI
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	22078883	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI
involved in response to bacterium	IMP IMP: Inferred from mutant phenotype	8612135	MGI
involved in response to molecule of bacterial origin	IDA IDA: Inferred from direct assay	15493995	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	8612135	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	15493995	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

monocyte differentiation antigen CD14

myeloid cell-specific leucine-rich glycoprotein

Recombinant Cd14 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73531	CD14 Protein, Mouse (HEK293, His)	P10810/NP_033971.1 (S16-P345)	≥95%
HY-P75444	CD14 Protein, Mouse (HEK293, His-Fc)	P10810/NP_033971.1 (S16-P345)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N9965	2'-Fucosyllactose	Inhibitor	99.95%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135750	VAF347	Agonist	99.90%	Unkown
HY-101132	VB-201		/	Unkown
HY-151399	Antimicrobial agent-5	Inhibitor	/	Unkown
HY-161901	BC-1293	Inhibitor	/	Unkown
HY-169067	10-Methoxy-canthin-6-one	Activator	/	Unkown
HY-RS02189	CD14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd14	NCBI	NCBI:929
Canis familiaris	Cd14	NCBI	NCBI:607076
Macaca fascicularis	Cd14	NCBI	NCBI:102129342
Leporidae	Cd14	NCBI
Rattus norvegicus	Cd14	NCBI	NCBI:60350
Macaca mulatta	Cd14	NCBI	NCBI:697482

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