2. MAPK/ERK Pathway
  3. p38 MAPK
  4. 10-Methoxy-canthin-6-one

0-Methoxy-canthin-6-one (Mtx-C) is a DNA damage inducer. 0-Methoxy-canthin-6-one promotes cell cycle arrest at the G2/M phase by intercalating into DNA, thereby inducing myeloid differentiation of acute myeloid leukemia (AML) cells and leukemic stem cells (LSCs). The myeloid differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 0-Methoxy-canthin-6-one can be used in leukemia research.

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10-Methoxy-canthin-6-one Chemical Structure

10-Methoxy-canthin-6-one Chemical Structure

CAS No. : 86293-40-5

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10-Methoxy-canthin-6-one Related Antibodies

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Description

0-Methoxy-canthin-6-one (Mtx-C) is a DNA damage inducer. 0-Methoxy-canthin-6-one promotes cell cycle arrest at the G2/M phase by intercalating into DNA, thereby inducing myeloid differentiation of acute myeloid leukemia (AML) cells and leukemic stem cells (LSCs). The myeloid differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 0-Methoxy-canthin-6-one can be used in leukemia research[1].

Cellular Effect
Cell Line Type Value Description References
DU-145 IC50
1.58 μg/mL
Compound: 43
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
[PMID: 34332400]
HCC1395 IC50
14.7 μg/mL
Compound: 43
Antiproliferative activity against human HCC1395 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCC1395 cells incubated for 48 hrs by MTT assay
[PMID: 34332400]
Molecular Weight

250.25

Formula

C15H10N2O2
CAS No.
SMILES

O=C1C=CC2=NC=CC3=C2N1C4=CC=C(OC)C=C34
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Purity & Documentation
References
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10-Methoxy-canthin-6-one Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

10-Methoxy-canthin-6-one86293-40-5Mtx-Cp38 MAPKAcute myeloid leukemia cellsLeukemic stem cells (LSCs)Inhibitorinhibitorinhibit

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