2. MAPK/ERK Pathway
  3. p38 MAPK
  4. 10-Methoxy-canthin-6-one

0-Methoxy-canthin-6-one (Mtx-C) is a DNA damage inducer. 0-Methoxy-canthin-6-one promotes cell cycle arrest at the G2/M phase by intercalating into DNA, thereby inducing myeloid differentiation of acute myeloid leukemia (AML) cells and leukemic stem cells (LSCs). The myeloid differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 0-Methoxy-canthin-6-one can be used in leukemia research.

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10-Methoxy-canthin-6-one Chemical Structure

10-Methoxy-canthin-6-one Chemical Structure

CAS No. : 86293-40-5

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10-Methoxy-canthin-6-one Related Antibodies

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

0-Methoxy-canthin-6-one (Mtx-C) is a DNA damage inducer. 0-Methoxy-canthin-6-one promotes cell cycle arrest at the G2/M phase by intercalating into DNA, thereby inducing myeloid differentiation of acute myeloid leukemia (AML) cells and leukemic stem cells (LSCs). The myeloid differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 0-Methoxy-canthin-6-one can be used in leukemia research[1].

Molecular Weight

250.25

Formula

C15H10N2O2
CAS No.
SMILES

O=C1C=CC2=NC=CC3=C2N1C4=CC=C(OC)C=C34
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10-Methoxy-canthin-6-one Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

10-Methoxy-canthin-6-one86293-40-5Mtx-Cp38 MAPKAcute myeloid leukemia cellsLeukemic stem cells (LSCs)Inhibitorinhibitorinhibit

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