2. MAPK/ERK Pathway
  3. p38 MAPK
  4. 10-Methoxy-canthin-6-one

10-Methoxy-canthin-6-one  (Synonyms: Mtx-C)

Cat. No.: HY-169067 Purity: 98.71%
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0-Methoxy-canthin-6-one (Mtx-C) is a DNA damage inducer. 0-Methoxy-canthin-6-one promotes cell cycle arrest at the G2/M phase by intercalating into DNA, thereby inducing myeloid differentiation of acute myeloid leukemia (AML) cells and leukemic stem cells (LSCs). The myeloid differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 0-Methoxy-canthin-6-one can be used in leukemia research.

For research use only. We do not sell to patients.

10-Methoxy-canthin-6-one Chemical Structure

10-Methoxy-canthin-6-one Chemical Structure

CAS No. : 86293-40-5

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Based on 1 publication(s) in Google Scholar

10-Methoxy-canthin-6-one Related Antibodies

Top Publications Citing Use of Products

View All p38 MAPK Isoform Specific Products:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

0-Methoxy-canthin-6-one (Mtx-C) is a DNA damage inducer. 0-Methoxy-canthin-6-one promotes cell cycle arrest at the G2/M phase by intercalating into DNA, thereby inducing myeloid differentiation of acute myeloid leukemia (AML) cells and leukemic stem cells (LSCs). The myeloid differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 0-Methoxy-canthin-6-one can be used in leukemia research[1].

Cellular Effect
Cell Line Type Value Description References
DU-145 IC50
1.58 μg/mL
Compound: 43
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
[PMID: 34332400]
HCC1395 IC50
14.7 μg/mL
Compound: 43
Antiproliferative activity against human HCC1395 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCC1395 cells incubated for 48 hrs by MTT assay
[PMID: 34332400]
Molecular Weight

250.25

Formula

C15H10N2O2
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C1C=CC2=NC=CC3=C2N1C4=CC=C(OC)C=C34
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 3.33 mg/mL (13.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9960 mL 19.9800 mL 39.9600 mL
5 mM 0.7992 mL 3.9960 mL 7.9920 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9960 mL 19.9800 mL 39.9600 mL 99.9001 mL
5 mM 0.7992 mL 3.9960 mL 7.9920 mL 19.9800 mL
10 mM 0.3996 mL 1.9980 mL 3.9960 mL 9.9900 mL
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10-Methoxy-canthin-6-one Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

10-Methoxy-canthin-6-one86293-40-5Mtx-Cp38 MAPKAcute myeloid leukemia cellsLeukemic stem cells (LSCs)Inhibitorinhibitorinhibit

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