2. Gene
  3. Cd86 - CD86 antigen Gene

Cd86 - CD86 antigen Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as B7; B70; MB7; B7-2; B7.2; CLS1; Ly58; ETC-1; Ly-58; MB7-2; Cd28l2; TS/A-2

Gene ID: 12524 | Gene type: protein coding

About Cd86

Summary

Predicted to enable signaling receptor binding activity. Involved in several processes, including CD40 signaling pathway; activation of Phospholipase C activity; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; defense response to virus; and positive regulation of T cell proliferation. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Is expressed in central nervous system and retina. Used to study Guillain-Barre syndrome. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd86 Products(1)

mRNA Protein Name
NM_019388.3 NP_062261.3 T-lymphocyte activation antigen CD86 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23241883 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within B cell activation IDA
IDA: Inferred from direct assay
19734906 MGI
involved in B cell activation IDA
IDA: Inferred from direct assay
23241883 MGI
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
19047410 MGI
acts upstream of or within defense response to virus IDA
IDA: Inferred from direct assay
17277142 MGI
acts upstream of or within positive regulation of T cell proliferation IGI
IGI: Inferred from genetic interaction
23793062 MGI
involved in positive regulation of immunoglobulin production IDA
IDA: Inferred from direct assay
23241883 MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
23241883 MGI
involved in toll-like receptor 3 signaling pathway IMP
IMP: Inferred from mutant phenotype
25158758 MGI
acts upstream of or within toll-like receptor signaling pathway IDA
IDA: Inferred from direct assay
19734906 MGI
Cellular Component GO Annotation Evidence Reference Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
12801066 MGI
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
16708399 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-lymphocyte activation antigen CD86

activation B7-2 antigen

early T cell costimulatory molecule-1

Recombinant Cd86 Proteins

Cat. No. Product Name Accession Purity
HY-P7635 B7-2/CD86 Protein, Mouse (HEK293, Fc) P42082 (V26-E245) ≥95%
HY-P7638 B7-2/CD86 Protein, Mouse (HEK293, His) P42082 (V24-K244) ≥95%

Cd86 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83710m Rat Anti-Mouse CD86 Antibody (FITC) FC Mouse

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-W016773 1,10-Decanediol 99.93% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99821 Ravagalimab Inhibitor 99.31% Phase 2
Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148980A Polyinosinic acid sodium / Unkown
HY-150749A ODN D-SL03 sodium 99.82% Unkown
HY-150749 ODN D-SL03 Inducer 99.82% Unkown
HY-148980 Polyinosinic acid / Unkown
HY-143410 Anti-inflammatory agent 16 Inhibitor / Unkown
HY-144675 LSD1-IN-13 Inhibitor / Unkown
HY-144675A LSD1-IN-13 hydrochloride Inhibitor / Unkown
HY-150740 ODN 21595 Inhibitor / Unkown
HY-150740A ODN 21595 sodium Inhibitor / Unkown
HY-152201 BTK-IN-18 Inhibitor / Unkown
HY-160227 ORN 06 Activator / Unkown
HY-161833 HSP90-IN-31 Inhibitor / Unkown
HY-170403 LSD1-IN-38 Inhibitor / Unkown
HY-173070 TLR7 agonist 29 / Unkown
HY-RS02274 CD86 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-168384 M04 / Unkown
HY-169819 Calcium influx inducer compound 634 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd86 NCBI NCBI:942
Macaca fascicularis Cd86 NCBI NCBI:102147235
Leporidae Cd86 NCBI
Rattus norvegicus Cd86 NCBI NCBI:56822
Macaca mulatta Cd86 NCBI NCBI:714390